Clinical Efficacy of Adebrelimab With or Without Apatinib Mesilate and SOX Neoadjuvant Therapy in Locally Advanced Gastric Cancer

NCT ID: NCT07314203

Last Updated: 2026-01-02

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: PHASE3
• Total Enrollment: 118 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2026-12-25
• Study Completion Date: 2028-08-25

Brief Summary

Exploring the pathological complete response rate (pCR) of locally advanced gastric cancer treated with adebelimab combined or not combined with apatinib mesylate and SOX neoadjuvant therapy

Conditions

Gastric Cancer; Surgery

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

research group

Study population received the combination of Adabelimab, Apatinib Mesylate, and SOX regimen

Group Type: EXPERIMENTAL

Apatinib Mesylate Tablets

Intervention Type: DRUG

Apatinib Mesylate

Interventions

Apatinib Mesylate Tablets

Apatinib Mesylate

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

3. No prior systemic chemotherapy, radiotherapy, targeted therapy, or immunotherapy for advanced disease. Subjects who have received prior (neo)adjuvant chemotherapy and/or radiotherapy are eligible provided the last dose was completed ≥ 6 months before randomisation.

4. At least one measurable lesion per RECIST 1.1 (see Appendix 2). 5. Eastern Cooperative Oncology Group performance status (ECOG PS) 0-1 (see Appendix 4).

6. Estimated life expectancy > 3 months. 7. Adequate major organ function defined as:

1. Haematology (obtained ≤ 14 days without transfusion):

1. Hb ≥ 80 g/L

2. WBC ≥ 3 × 10⁹/L

3. ANC ≥ 1.5 × 10⁹/L

4. PLT ≥ 100 × 10⁹/L

2. Biochemistry:

1. Total bilirubin < 1.5 × upper limit of normal (ULN)

2. ALT and AST < 2.5 × ULN; ALP ≤ 1.5 × ULN

3. Serum creatinine ≤ 1 × ULN and calculated creatinine clearance ≥ 60 mL/min (Cockcroft-Gault formula) 8. Women of child-bearing potential must have a negative serum pregnancy test within 7 days prior to enrolment and must use highly effective contraception from screening until 8 weeks after the last dose of study drug. Men must be surgically sterile or agree to use effective contraception during the same period.

9. No participation in any other interventional clinical trial during the pre-treatment or on-treatment phases of this study.

10. Voluntary written informed consent obtained; willing and able to comply with study procedures and follow-up.

Exclusion Criteria

Subjects meeting any of the following conditions will be excluded from enrollment:

1. Known or suspected hypersensitivity to the investigational drug or any drug of the same class.

2. Other malignancies within the past 5 years, except adequately treated basal-cell or squamous-cell carcinoma of the skin or carcinoma in situ of the cervix.

3. Currently receiving treatment in another interventional clinical trial, or any systemic anti-gastric-cancer therapy within 4 weeks prior to the first dose.

4. Systemic Chinese patent medicines with anti-tumor indications or immunomodulatory agents (e.g., thymosin, interferon, interleukins; local intrapleural use for effusion control is permitted) received within 2 weeks before the first dose.

5. Prior exposure to: anti-PD-1, anti-PD-L1, anti-PD-L2, or any agent targeting other T-cell co-stimulatory or co-inhibitory pathways (including but not limited to CTLA-4, OX-40, CD137); or prior chemotherapy including S-1.

6. Live-vaccine administration within 4 weeks before enrollment or planned during the study.

Note: Inactivated seasonal influenza vaccine by injection is allowed within 4 weeks; intranasal live-attenuated influenza vaccine is prohibited.

7. Active autoimmune disease requiring systemic therapy (e.g., immunosuppressants, corticosteroids, or disease-modifying agents) within 2 years before the first dose. Replacement therapy (thyroxine, insulin, physiologic glucocorticoids for adrenal or pituitary insufficiency) is not considered systemic therapy.

8. Prior allogeneic bone-marrow or solid-organ transplantation.

9. Any condition that could impair drug absorption or inability to swallow oral medication.

10. Uncontrolled hypertension despite optimal medical management:

• SBP ≥ 150 mmHg or DBP ≥ 100 mmHg on a single antihypertensive, or requirement of ≥ 2 antihypertensive agents.

11. Urinalysis showing proteinuria ≥ 2+ and 24-h urinary protein > 1.0 g.

12. Active gastro-duodenal ulcer, ulcerative colitis, or other gastrointestinal disorders with bleeding risk; un-resected tumors with active hemorrhage; or any other condition judged by the investigator to predispose to GI bleeding or perforation.

13. Significant bleeding tendency within 3 months before enrollment: overt bleeding > 30 mL, hematemesis, melena, hematochezia; hemoptysis (> 5 mL fresh blood within 4 weeks); or thrombo-embolic event (including stroke/TIA) within 12 months.

14. Clinically significant cardiovascular disease:

• Acute MI, unstable/severe angina, or CABG within 6 months before enrollment;
• NYHA class > II congestive heart failure;
• Ventricular arrhythmia requiring therapy;
• QTc ≥ 480 ms on baseline ECG.

15. Active or uncontrolled severe infection (≥ CTCAE grade 2).

16. Known HIV infection; clinically significant hepatic disorders:

• Chronic hepatitis B with active replication (HBV DNA > 1 × 10⁴ copies/mL or > 2000 IU/mL);
• Hepatitis C with detectable HCV RNA (> 1 × 10³ copies/mL);
• Other hepatitis or cirrhosis.

17. Known dihydropyrimidine dehydrogenase (DPD) deficiency.

18. Any condition that, in the opinion of the investigator, would compromise the subject's safety or interfere with study participation.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Fujian Medical University

OTHER

Sponsor Role: lead

Responsible Party

Chang-Ming Huang, Prof.

Chief doctor, phD, FACS

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Fujian Medical University Union Hospital

Fuzhou, Fujian, China

Countries

China

Central Contacts

ChangMing Huang, MD，PhD

Role: CONTACT

hcmlr2002@163.com

+8613805069676

Facility Contacts

ChangMing Huang, MD

Role: primary

hcmlr2002@163.com

+8613805069676

Other Identifiers

SOP-XH-IRB

Identifier Type: -

Identifier Source: org_study_id