Long Term Effectiveness of Levodopa-Entacapone-Carbidopa Intestinal Gel in Participants With Advanced Parkinson's Disease

NCT ID: NCT07313176

Last Updated: 2025-12-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

215 participants

Study Classification

OBSERVATIONAL

Study Start Date

2026-01-31

Study Completion Date

2029-01-31

Brief Summary

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The primary objective of the study is to assess the effectiveness of LECIGON® treatment on the reduction in OFF time (h/day) from baseline at 12 months as measured by Movement Disorder Society-Unified Parkinson's Disease Rating Scale, Part IV (MDS-UPDRS IV).

Detailed Description

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Conditions

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Advanced Parkinson Disease

Keywords

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Parkinson´s Disease Movement Disorders Portable Pump Neurodegenerative Disorder Subcutaneous Foslevodopa Quality of Life Dopamine Agonists

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Participants Receiving LECIGON® Treatment

All participants with advanced Parkinson's disease who switched from subcutaneous foslevodopa (foslevodopa-foscarbidopa) to LECIGON®, will be observed in the study. Participants real-world data on the long-term effectiveness of LECIGON® in routine clinical practice will be observed.

No Intervention

Intervention Type OTHER

This is a non-interventional study.

Interventions

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No Intervention

This is a non-interventional study.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Adult participants (18 years old and over) with advanced Parkinson's disease with severe motor fluctuations and dyskinesia
* Participants for whom the treating physician has made the decision to initiate treatment with LECIGON® in accordance with the Summary of Product Characteristics (SmPC)
* Participants must have had previous treatment with subcutaneous foslevodopa (foslevodopa-foscarbidopa) for a minimum of 1 month
* Participants or legal representative must have signed informed consent to participate in the study

Exclusion Criteria

* Participants with contraindications as defined in the current version of the SmPC for LECIGON®
* Participants who will not be seen again for their follow up care at the investigator's site after commencement of LECIGON® therapy
* Participants with anticipated pump placement or pump use issues, e.g. participants with acute severe illness, participants unable to perform pump therapy, and in case of lacking compliance due to severe dementia, agitation or alcohol abuse
* Participants taking part in a clinical (interventional) trial at the same time
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Britannia Pharmaceuticals Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Central Contacts

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Sukhdeep Singh, MSci Pharmacology

Role: CONTACT

Phone: +44 07954751548

Email: [email protected]

Niall Smith

Role: CONTACT

Email: [email protected]

Other Identifiers

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NIS-MA-2025-01

Identifier Type: -

Identifier Source: org_study_id