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Topical Use of 2% Tofacitinib for Nail Psoriasis: an Exploratory Clinical Study

NCT ID: NCT07313072

Last Updated: 2025-12-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

PHASE2

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2026-03-31

Study Completion Date

2027-03-31

Brief Summary

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To evaluate the efficacy and safety of topical 2% tofacitinib nail lacquer in nail psoriasis, using the NAPSI and DLQI scales before and after 26 weeks of treatment.

Detailed Description

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Conditions

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Nail Psoriasis

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Medicated Nail Lacquer

Group Type EXPERIMENTAL

Topical 2% Tofacitinib

Intervention Type DRUG

Each study participant will receive a bottle of nail lacquer containing 2% tofacitinib. Application will be the responsibility of the participant and must be performed once daily throughout the entire study period.

Interventions

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Topical 2% Tofacitinib

Each study participant will receive a bottle of nail lacquer containing 2% tofacitinib. Application will be the responsibility of the participant and must be performed once daily throughout the entire study period.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Presence of nail psoriasis in at least one fingernail or toenail;
* Patients not using systemic medication, or without adequate response to systemic medication after at least 6 months of use;
* Ability to read, understand, and sign the Informed Consent Form (ICF) and the Consent Form for Images, Presentations, and Scientific Publications.

Exclusion Criteria

* History of sensitivity to any components of the study product;
* Initiation of systemic medication for nail psoriasis less than six months prior.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hexsel Dermatology Clinic

OTHER

Sponsor Role lead

Responsible Party

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Doris Hexsel

Dr

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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12-DPCHD25-04

Identifier Type: -

Identifier Source: org_study_id