Epidemiological, Clinical and Biological Characteristics of Human Anaplasmosis Cases in Alsace

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-10-02

Study Completion Date

2026-02-28

Brief Summary

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Anaplasmosis is a bacterial infection caused by the intracellular bacterium Anaplasma phagocytophilum and transmitted by ticks. This bacterium is present in approximately 1% of ticks in Alsace. This infection is responsible for clinical manifestations that are most often mild, including fever, headache, and myalgia, occurring 2 to 3 weeks after a tick bite. However, this infection can be accompanied by potentially serious or even fatal complications, including severe cytopenias, acute respiratory distress syndrome, septic shock, severe neurological disorders, hemorrhagic manifestations, macrophage activation syndrome, and multiple organ failure. Mortality is variable and appears to be higher in American studies, where it is around 4%. Treatment is well-established and relies on doxycycline, which is highly effective. Although a few cases have been described in France, these are mostly isolated cases or short series of cases, whereas Belgium, Poland, and Slovenia have reported numerous cases. Thus, there is a lack of data on French cases, and given that Alsace is in a region with a high prevalence of tick-borne diseases, data is needed to better understand the epidemiology and to better identify suspected cases in order to provide appropriate care.

Detailed Description

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Conditions

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Human Anaplasmosis

Keywords

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Human Anaplasmosis Ticks Tick bite Severe cytopenias Respiratory distress syndrome Septic shock Neurological disorders Macrophage activation syndrome

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Adult subjct (≥18 years)
* Presenting with a PCR-confirmed infection of Anaplasma

Exclusion Criteria

\- Refusal to participate in the study

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Responsibility Role SPONSOR

Locations

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Service des Maladies Infectieuses et Tropicales - CHU de Strasbourg - France

Strasbourg, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Victor GERBER, MD

Role: CONTACT

Phone: 33 3.88.11.67.68

Email: [email protected]

Facility Contacts

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Victor Gerber, MD

Role: primary

Other Identifiers

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9458

Identifier Type: -

Identifier Source: org_study_id