Impact of Exercise-derived Extracellular Vesicle in Blood and Physical Fitness Data in Overweight/Obesity Individuals
NCT ID: NCT07312344
Last Updated: 2025-12-31
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
20 participants
INTERVENTIONAL
2025-08-30
2026-01-31
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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High-intensity interval training exercise
High-intensity interval training exercise 3 days per week for 6 weeks
High-intensity interval training exercise on treadmill
High-intensity interval training exercise using 65% to 80% of heart rate max
Interventions
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High-intensity interval training exercise on treadmill
High-intensity interval training exercise using 65% to 80% of heart rate max
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
2. Thai nationality
3. Ability to walk or perform daily activities independently, without the use of an assistive device
4. Body mass index (BMI) between 25-35 kg/m²
5. Low physical activity levels or sedentary lifestyle based on the World Health Organization 2020
* The levels of moderate-intensity physical activity \< 150-300 minutes per week or the levels of vigorous-intensity physical activity \< 75-150 minutes per week
Exclusion Criteria
2. History of respiratory diseases, such as asthma, emphysema, or chronic obstructive pulmonary disease
3. History of cardiovascular diseases, such as coronary heart disease, aortic disease, arrhythmia, or deep vein thrombosis
4. History of high blood pressure (hypertension)
5. History of vestibular system diseases, such as Meniere's disease or otitis media
6. History of neurological disease, such as severe Parkinson's disease or stroke
7. History of previous lower limb surgery, such as hip, knee, or ankle replacement
8. History of musculoskeletal diseases, such as severe osteoarthritis
9. History of severe brain disease, such as dementia
10. Severe visual or hearing impairment
11. Have a cognitive and comprehensive impairment and unable to complete the intervention
12. Have high physical activity or regularly exercise
25 Years
45 Years
ALL
No
Sponsors
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Mahidol University
OTHER
Responsible Party
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Locations
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Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital
Mueang Samut Prakan, , Thailand
Countries
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Central Contacts
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References
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Gremeaux V, Drigny J, Nigam A, Juneau M, Guilbeault V, Latour E, Gayda M. Long-term lifestyle intervention with optimized high-intensity interval training improves body composition, cardiometabolic risk, and exercise parameters in patients with abdominal obesity. Am J Phys Med Rehabil. 2012 Nov;91(11):941-50. doi: 10.1097/PHM.0b013e3182643ce0.
Ryan BJ, Schleh MW, Ahn C, Ludzki AC, Gillen JB, Varshney P, Van Pelt DW, Pitchford LM, Chenevert TL, Gioscia-Ryan RA, Howton SM, Rode T, Hummel SL, Burant CF, Little JP, Horowitz JF. Moderate-Intensity Exercise and High-Intensity Interval Training Affect Insulin Sensitivity Similarly in Obese Adults. J Clin Endocrinol Metab. 2020 Aug 1;105(8):e2941-59. doi: 10.1210/clinem/dgaa345.
Turk Y, Theel W, Kasteleyn MJ, Franssen FME, Hiemstra PS, Rudolphus A, Taube C, Braunstahl GJ. High intensity training in obesity: a Meta-analysis. Obes Sci Pract. 2017 May 29;3(3):258-271. doi: 10.1002/osp4.109. eCollection 2017 Sep.
He XF, Liu DX, Zhang Q, Liang FY, Dai GY, Zeng JS, Pei Z, Xu GQ, Lan Y. Voluntary Exercise Promotes Glymphatic Clearance of Amyloid Beta and Reduces the Activation of Astrocytes and Microglia in Aged Mice. Front Mol Neurosci. 2017 May 19;10:144. doi: 10.3389/fnmol.2017.00144. eCollection 2017.
Aspelund A, Antila S, Proulx ST, Karlsen TV, Karaman S, Detmar M, Wiig H, Alitalo K. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. J Exp Med. 2015 Jun 29;212(7):991-9. doi: 10.1084/jem.20142290. Epub 2015 Jun 15.
Louveau A, Smirnov I, Keyes TJ, Eccles JD, Rouhani SJ, Peske JD, Derecki NC, Castle D, Mandell JW, Lee KS, Harris TH, Kipnis J. Structural and functional features of central nervous system lymphatic vessels. Nature. 2015 Jul 16;523(7560):337-41. doi: 10.1038/nature14432. Epub 2015 Jun 1.
Secker GA, Harvey NL. VEGFR signaling during lymphatic vascular development: From progenitor cells to functional vessels. Dev Dyn. 2015 Mar;244(3):323-31. doi: 10.1002/dvdy.24227. Epub 2014 Dec 4.
Other Identifiers
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2025/1365
Identifier Type: REGISTRY
Identifier Source: secondary_id
MURA2025/678
Identifier Type: -
Identifier Source: org_study_id