Perinatal Risk Factors in Motor Development

NCT ID: NCT07310459

Last Updated: 2025-12-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

160 participants

Study Classification

OBSERVATIONAL

Study Start Date

2026-02-01

Study Completion Date

2026-04-30

Brief Summary

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The aim of this study is to analyze the effect of preterm gestational age, birth weight and perinatal risks factors on gross motor development of preterm infants.

We will compare the data of infants evaluated by the Alberta Infant Motor Scale (AIMS) and the Perinatal Risk Inventory (PERI) in an Infant Development and Early Intervention Center (IDEIC).

Detailed Description

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An assessment of the infants' gross motor development will be carried out at admission, of IDEIC following the AIMS scale and bearing in mind their corrected age. Importantly, the trimester according to their corrected age was also recorded.

The gestational age of each infant will be recorded and used to group participants according to the following classification: late preterm newborn infant (LPNI; born between 34+1 and 36+6 weeks of gestation); moderate preterm newborn infant (MPNI; born between 32+1 to 34 weeks of gestation); very preterm newborn infant (VPNI; born between 28 to 32 weeks of gestation); and extreme preterm newborn infant (EPNI; born before 28 weeks of gestation).

The birth weight will be recorded and the infants will be grouped according to the following classification: newborns with adequate birth (birth weight of \>2500 g), low birth weight (LBW; \<2500 g and \>1500 g); very low birth weight (VLBW; \<2500 g and \>1000 g), and extreme low birth weight (ELBW; \<1000 g).

The infants will be assessed by the PERI test accounting for their discharge medical records. The infants will be then classified according to the biological risk level, in low, moderate and high risk.

Both the PERI and the AIMS test were assessed by three physiotherapists from the IDEIC with 10 to 20 years of experience.

Afterwards data will be analyzed using the Statistical Package for the Social Sciences Statistics (IBM SPSS) software for Windows version 22.0.

From all data collected as described in the brief summary, descriptive analysis and correlations between variables will be performed.

Samples will be classified using descriptive and frequency analysis. One-factor ANOVA, bivariate correlations will be carried out. Correlations between variables will be evaluated using Pearson's coefficient (bivariate correlation) or Spearman's coefficient (rank correlation). Frequencies analysis, square Chi test and backwards regression analysis will be used when appropriate.

AIMS direct scores will be standardized by converting them into Z scores. AIMS standard mean and deviation by age and gender will be used.

Conditions

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Premature Infant Risk Factors Motor Development of Premature Infants

Study Design

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Observational Model Type

OTHER

Study Time Perspective

RETROSPECTIVE

Study Groups

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Group of Preterm infants

Preterm infants cared at the "Fina Navarro Lopez" Childhood Development and Early Intervention Center (Lorca) between 2023 and 2025 who have been assessed using the Alberta Infant Motor Scale and the Perinatal Risk Inventory

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* preterm infants showing biological risk factors
* parents or tutors signe an informed consent.

Exclusion Criteria

* Diagnosis of encephalopathy
* genetic syndromes
* congenital malformations
* neuromuscular disorders
* myopathies
* metabolic and oncologic diseases
Maximum Eligible Age

18 Months

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Universidad de Murcia

OTHER

Sponsor Role lead

Responsible Party

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Francisco Javier Fernandez Rego

Doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Francisco Javier Fernandez Rego, PhD

Role: PRINCIPAL_INVESTIGATOR

Universidad de Murcia

Locations

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CDIAT Fina Navarro Lopez

Lorca, Murcia, Spain

Site Status

Countries

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Spain

Central Contacts

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Francisco Javier Fernandez Rego, PhD

Role: CONTACT

Phone: +34 666557827

Email: [email protected]

Galaad Torro Ferrero, PhD

Role: CONTACT

Phone: +34 685306937

Email: [email protected]

Facility Contacts

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Francisco Javier Fernandez Rego, PhD

Role: primary

+34

Role: backup

References

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Pritchard MA, Colditz PB, Cartwright D, Gray PH, Tudehope D, Beller E. Risk determinants in early intervention use during the first postnatal year in children born very preterm. BMC Pediatr. 2013 Dec 5;13:201. doi: 10.1186/1471-2431-13-201.

Reference Type BACKGROUND
PMID: 24304976 (View on PubMed)

Zaramella P, Freato F, Milan A, Grisafi D, Vianello A, Chiandetti L. Comparison between the perinatal risk inventory and the nursery neurobiological risk score for predicting development in high-risk newborn infants. Early Hum Dev. 2008 May;84(5):311-7. doi: 10.1016/j.earlhumdev.2007.08.003. Epub 2007 Sep 27.

Reference Type BACKGROUND
PMID: 17897797 (View on PubMed)

Thomaidis L, Zantopoulos GZ, Fouzas S, Mantagou L, Bakoula C, Konstantopoulos A. Predictors of severity and outcome of global developmental delay without definitive etiologic yield: a prospective observational study. BMC Pediatr. 2014 Feb 12;14:40. doi: 10.1186/1471-2431-14-40.

Reference Type BACKGROUND
PMID: 24521451 (View on PubMed)

Christian P, Murray-Kolb LE, Tielsch JM, Katz J, LeClerq SC, Khatry SK. Associations between preterm birth, small-for-gestational age, and neonatal morbidity and cognitive function among school-age children in Nepal. BMC Pediatr. 2014 Feb 27;14:58. doi: 10.1186/1471-2431-14-58.

Reference Type BACKGROUND
PMID: 24575933 (View on PubMed)

Other Identifiers

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CDIAT Lorca 1/2025

Identifier Type: -

Identifier Source: org_study_id