Longitudinal Evaluation of Direct Neurotization Technique in Breast Reconstruction With Fully Autologous Components

NCT ID: NCT07308275

Last Updated: 2025-12-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

28 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-12-15

Study Completion Date

2027-04-15

Brief Summary

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This clinical trial aims to evaluate whether direct neurotization using fully autologous components during autologous breast reconstruction improves postoperative breast sensation and sensory-related quality of life in women undergoing unilateral mastectomy. Direct neurotization involves coapting the recipient intercostal nerve to an autologous nerve graft placed within the flap to facilitate reinnervation.

The study's primary questions are:

1. Does direct neurotization using fully autologous nerve grafts improve cutaneous sensory recovery, as assessed by Semmes-Weinstein monofilament thresholds measured at standardized breast locations?
2. Does neurotization enhance patient-reported sensory outcomes and quality of life, as assessed by the BREAST-Q Sensation Module?

As secondary objectives, the study will assess whether biological predictors of nerve regeneration correlate with sensory outcomes. These include:

1. Neuregulin-1 (NRG1) expression in flap tissue biopsy;
2. Cross-sectional area of the recipient nerve fibres;
3. Breast morphometry measured at baseline and follow-up;
4. Intraepidermal nerve fibre density (IENFD) on skin biopsy.

Participants will be randomly assigned to receive either:

1. Neurotized autologous breast reconstruction using fully autologous graft components, or
2. Standard (non-neurotized) autologous breast reconstruction.

The study will compare these groups to determine whether neurotization accelerates or enhances the return of breast sensation over a 6-month follow-up period, with evaluations at 1 month, 3 months, and 6 months after surgery.

Participants will undergo:

1. Autologous breast reconstruction with or without direct neurotization as part of their planned cancer surgery.
2. Sensory testing using Semmes-Weinstein monofilaments at baseline, 1, 3, and 6 months.
3. Completion of BREAST-Q questionnaires evaluating breast sensation, symptoms, and quality of life at each follow-up visit.

3\. Intraoperative tissue sampling for NRG1 analysis and nerve morphometry. 4. Skin biopsy (if applicable) to assess intraepidermal nerve fibre density. 5. Breast morphometry assessment using a breast morphometry measurement software tool.

This study seeks to provide high-quality evidence on the effectiveness of direct neurotization using fully autologous components in restoring breast sensation and to explore biological predictors that may influence sensory recovery after autologous breast reconstruction.

Detailed Description

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Conditions

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Breast Reconstruction After Mastectomy Neurotization Mastectomy and Breast Reconstruction Peripheral Nerve Regeneration Sensory Function Quality of Life (QOL)

Keywords

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breast neurotization mastectomy breast sensory quality of life

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Non-Neurotized Group

Participants assigned to this arm are women undergoing mastectomy who are eligible for standard autologous breast reconstruction without neurotization.

Group Type ACTIVE_COMPARATOR

Autologous Breast Reconstruction without Neurotization

Intervention Type PROCEDURE

Breast reconstruction is performed using autologous tissue without nerve coaptation or neurotization, according to standard surgical practice.

Neurotized Group

Participants assigned to this arm are women undergoing mastectomy who are eligible for autologous breast reconstruction with planned direct neurotization using fully autologous components.

Group Type EXPERIMENTAL

Autologous Breast Reconstruction With Direct Neurotization

Intervention Type PROCEDURE

The direct neurotization using fully autologous components procedures include:

1. Direct neurotization is carried out using fully autologous components, involving coaptation of the recipient nerve to an autologous nerve graft placed within the flap to facilitate reinnervation.
2. Surgical breast reconstruction is then completed using patient's own tissue

Interventions

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Autologous Breast Reconstruction With Direct Neurotization

The direct neurotization using fully autologous components procedures include:

1. Direct neurotization is carried out using fully autologous components, involving coaptation of the recipient nerve to an autologous nerve graft placed within the flap to facilitate reinnervation.
2. Surgical breast reconstruction is then completed using patient's own tissue

Intervention Type PROCEDURE

Autologous Breast Reconstruction without Neurotization

Breast reconstruction is performed using autologous tissue without nerve coaptation or neurotization, according to standard surgical practice.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Female patients aged ≥18 years.
* Patients with unilateral breast cancer who have undergone or will undergo unilateral mastectomy.
* Patients undergoing breast reconstruction.
* Patients with unilateral breast cancer regardless of adjuvant therapy status (receiving radiotherapy and/or chemotherapy or receiving no adjuvant therapy).
* Willing to comply with all scheduled examinations and tissue sampling procedures.
* Able and willing to provide written informed consent.

Exclusion Criteria

* History of peripheral neuropathy (e.g., diabetes mellitus with neuropathic complications).
* Bilateral mastectomy.
* Presence of skin or soft-tissue conditions of the breast that may interfere with sensory assessment.
* Active smokers (use of tobacco, vape, or other nicotine products within 14 days prior to neurotization).
* Refusal or inability to attend follow-up evaluations.
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Fakultas Kedokteran Universitas Indonesia

OTHER

Sponsor Role lead

Responsible Party

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Mohamad Rachadian Ramadan

dr. Mohamad Rachadian Ramadan, B.Med.Sc, Sp.B.P.R.E, Subsp.M.O.(K), MRBS

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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dr. Ciptomangunkusumo National Hospital - Faculty of Medicine Universitas Indonesia

Jakarta Pusat, Jakarta Special Capital Region, Indonesia

Site Status

Countries

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Indonesia

Central Contacts

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Mohamad Rachadian Ramadan, MD., MRBS.

Role: CONTACT

Phone: +62881082855557

Email: [email protected]

Facility Contacts

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Ayu PB Sarena, MD, MPH

Role: primary

References

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Other Identifiers

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STUDINEUROTISASI

Identifier Type: -

Identifier Source: org_study_id