Evaluation of a New MRI Technique to Reduce Breathing-Related Artifacts in Brain Imaging
NCT ID: NCT07305948
Last Updated: 2025-12-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
100 participants
OBSERVATIONAL
2026-01-05
2027-12-31
Brief Summary
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The investigated method measures breathing-related magnetic field variations during MRI acquisition using two very short navigator signals, referred to as free induction decay (FID) navigators. These signals are used to perform dynamic off-resonance correction during image reconstruction, reducing image blurring and distortion. The method does not increase scan time and does not affect standard clinical imaging.
In this study, patients scheduled for routine clinical brain MRI are asked to provide informed consent for use of their raw MRI data for research purposes. For each participant, two sets of SWI images are generated from the same acquisition: one using standard reconstruction and one using the free induction decay navigator-based dynamic off-resonance correction method (FID-DORK). The objective is to assess whether the corrected images provide improved image quality and diagnostic reliability.
The study includes adult patients undergoing routine clinical MRI at Karolinska University Hospital. Image quality is evaluated using both visual assessment by neuroradiologists and quantitative measures of image variation. No additional imaging procedures, contrast agents, or scan time are required. All research data are pseudonymized prior to analysis.
The hypothesis is that the dual free induction decay navigator-based correction method (FID-DORK) improves the diagnostic quality of high-resolution three-dimensional echo-planar imaging susceptibility-weighted imaging brain MRI by reducing breathing-related artifacts.
Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Patients Undergoing Routine Clinical Brain MRI
Dual Free Induction Decay (FID) Navigator Off-Resonance Corrected (DORK) 3D Susceptibility Weighted (SWI) Echo Planar Imaging (EPI)
This intervention consists of a modified magnetic resonance imaging (MRI) acquisition and reconstruction method used during routine clinical brain imaging. The method adds two very short free-induction-decay (FID) navigator signals to each repetition of a high-resolution 3D echo planar imaging (EPI) susceptibility-weighted imaging (SWI) sequence. These navigator signals measure breathing-related magnetic field changes, which are then used to perform dynamic off-resonance correction (DORK) during image reconstruction. The modified sequence does not change the clinical scan time or affect patient care. For each participant, both uncorrected and corrected SWI images are generated from the same raw data.
Interventions
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Dual Free Induction Decay (FID) Navigator Off-Resonance Corrected (DORK) 3D Susceptibility Weighted (SWI) Echo Planar Imaging (EPI)
This intervention consists of a modified magnetic resonance imaging (MRI) acquisition and reconstruction method used during routine clinical brain imaging. The method adds two very short free-induction-decay (FID) navigator signals to each repetition of a high-resolution 3D echo planar imaging (EPI) susceptibility-weighted imaging (SWI) sequence. These navigator signals measure breathing-related magnetic field changes, which are then used to perform dynamic off-resonance correction (DORK) during image reconstruction. The modified sequence does not change the clinical scan time or affect patient care. For each participant, both uncorrected and corrected SWI images are generated from the same raw data.
Eligibility Criteria
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Inclusion Criteria
* Undergoing a routine clinical brain MRI at Karolinska University Hospital
* Able to understand the study information and provide written informed consent
* Sequence parameters and scan protocol compatible with the research acquisition (3D-EPI SWI)
Exclusion Criteria
* Standard contraindications to MRI (e.g., non-MRI safe implants, severe claustrophobia)
* Clinical conditions requiring urgent imaging where research consent is not feasible
* Significant motion or incomplete scans preventing creation of research images (rare)
18 Years
ALL
No
Sponsors
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Region Stockholm
OTHER_GOV
Responsible Party
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Locations
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Karolinska University Hospital
Stockholm, Solna, Sweden
Countries
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Central Contacts
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Facility Contacts
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Ola Norbeck, PhD
Role: primary
Other Identifiers
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K2025-9116
Identifier Type: -
Identifier Source: org_study_id