Sleep Treatment for Teens (RCT Phase)

NCT ID: NCT07303959

Last Updated: 2025-12-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-06-02

Study Completion Date

2026-03-01

Brief Summary

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The purpose of this research study is to compare (vs. treatment as usual) a brief (6-session), empirically supported, and highly disseminable version of digital (i.e., smartphone or web-based) cognitive behavioral therapy for insomnia (dCBT-I), called SleepioTM, in suicidal adolescents with co-occurring insomnia during the high-risk post-hospitalization period. Suicide is the 2nd leading cause of death among adolescents. Sleep problems, such as insomnia symptoms-the most common sleep problem in youth-may be a particularly promising treatment target to reduce suicide risk in adolescents. The investigators propose to test the feasibility, acceptability, and effectiveness of dCBT-I in a two-site (Rutgers and Old Dominion University) pilot study trial. Adolescents, 14-18 years-old, recently hospitalized for suicide risk with co-occurring insomnia (n=80, 50% at each site), will receive either dCBT-I (six weekly, 20-minute sessions) plus post-hospitalization treatment-as-usual (TAU) or TAU alone. Adolescents will complete assessments pre-treatment, during the treatment phase including at the end of treatment, and 1-month follow-up post-treatment.

Detailed Description

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Conditions

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Sleep Problems Suicidal Ideation Suicidal Behavior

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Treatment as usual (TAU) + ecological momentary assessment (EMA)

Treatment as usual plus assessments via EMA

Group Type ACTIVE_COMPARATOR

Treatment as Usual (TAU)

Intervention Type BEHAVIORAL

Treatment as usual as part of standard inpatient care, and any outpatient care received.

Sleepio (TM) + Treatment as usual (TAU) + EMA

Sleepio is a mobile Digital Cognitive Behavior Therapy for Insomnia (dCBT-I) app.

Group Type EXPERIMENTAL

Sleepio

Intervention Type BEHAVIORAL

Sleepio is a mobile Digital Cognitive Behavior Therapy for Insomnia (dCBT-I) app.

Treatment as Usual (TAU)

Intervention Type BEHAVIORAL

Treatment as usual as part of standard inpatient care, and any outpatient care received.

Interventions

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Sleepio

Sleepio is a mobile Digital Cognitive Behavior Therapy for Insomnia (dCBT-I) app.

Intervention Type BEHAVIORAL

Treatment as Usual (TAU)

Treatment as usual as part of standard inpatient care, and any outpatient care received.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

1. Age 14-18 years old.
2. Recent hospitalization due to suicide risk (i.e., suicide attempts, aborted/interrupted attempts, or suicide ideation with intent and/or a plan) using an abbreviated version of the semi-structured and well-validated Columbia Suicide Severity Rating Scale (C-SSRS; Posner et al., 2011). Regarding recency, adolescents will need to complete the baseline within three months (Study 1) or 45 days (Study 2) of discharge in order to capture the high-risk post-discharge period, which is up to 3 months following discharge from acute psychiatric hospitalization (Chung et al., 2017).
3. Clinically significant insomnia symptoms: SCI scores ≤16 will be used to recruit a sample with clinically significant insomnia symptoms. The ISI will also be administered to gain additional information about the nature of adolescents' sleep problems in order to confirm primary insomnia. ISI scores may also be obtained via chart review when applicable
4. Access to or willingness to use a compatible Smart Device. SleepioTM works with any internet connection (cellular or Wifi) on any iOS device running iOS 10.3 or later or on any Android device running Android OS 8.0 or later. Metricwire is compatible with all devices that SleepioTM is compatible with. If an interested adolescent does not have access to their own smart device, the research team will offer them a loaner device for the duration of the treatment/follow-up phase.

Exclusion Criteria

1. Prior CBT-I treatment, which would indicate lack of response to a prior reasonable dose of this treatment.
2. Bipolar disorder given that certain components of CBT-I (e.g., sleep restriction) may be risky for this population.
3. Substance use disorder that is primary to insomnia which would require alternative treatment.
4. Presence of factors that may reduce participants' ability to consent or complete the study procedures (e.g., current psychosis, other-directed violence; severe cognitive impairment, non-English speaking).
5. Unwillingness to wear wrist actigraphy or complete the EMA surveys.
6. Not having a parent willing to provide permission (if participant is a minor) or to consent to their own participation (required for all adolescents). Eligibility will not be based on biological sex, gender identity, race, or ethnicity. These variables will be assessed during screening to compare those who are and are not eligible.
7. Having a sibling who has enrolled in the study.
Minimum Eligible Age

14 Years

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Institute of Mental Health (NIMH)

NIH

Sponsor Role collaborator

Old Dominion University

OTHER

Sponsor Role collaborator

Children's Hospital of The King's Daughters

OTHER

Sponsor Role collaborator

Rutgers, The State University of New Jersey

OTHER

Sponsor Role lead

Responsible Party

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Evan M. Kleiman, Ph.D.

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Evan Kleiman

Role: PRINCIPAL_INVESTIGATOR

Rutgers

Locations

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Rutgers University Behavioral Healthcare

Piscataway, New Jersey, United States

Site Status RECRUITING

Children's Hospital of The King's Daughters

Norfolk, Virginia, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Evan Kleiman, PhD

Role: CONTACT

Phone: 848-445-2345

Email: [email protected]

Facility Contacts

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Evan Kleiman

Role: primary

Catherine Glenn

Role: primary

Provided Documents

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Document Type: Informed Consent Form: new

View Document

Other Identifiers

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R34MH123590

Identifier Type: NIH

Identifier Source: secondary_id

View Link

Pro2021001233_mod 10

Identifier Type: -

Identifier Source: org_study_id