Surgical Techniques to Prevent Perioperative Neurologic Complications in Patients Undergoing Coronary Artery Bypass Grafting
NCT ID: NCT07302659
Last Updated: 2025-12-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
380 participants
INTERVENTIONAL
2026-01-01
2028-06-30
Brief Summary
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This multicenter, randomized controlled clinical trial will evaluate the benefits of a novel aortic no-touch technique in reducing perioperative silent brain infarction(SBI) among patients undergoing surgical treatment for coronary artery disease. The findings are expected to provide a safe and effective myocardial revascularization strategy for individuals at high risk of cerebral ischemia.
Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
SINGLE
Study Groups
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Traditional off-pump coronary artery bypass grafting (TA-SVG)
No interventions assigned to this group
Aortic no-touch coronary artery bypass grafting (RIMA-SVG)
Aortic no-touch coronary artery bypass grafting (RIMA-SVG)
Ascending aortic no-touch CABG with saphenous vein graft (SVG) anastomosed to the right internal mammary artery (RIMA)
Interventions
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Aortic no-touch coronary artery bypass grafting (RIMA-SVG)
Ascending aortic no-touch CABG with saphenous vein graft (SVG) anastomosed to the right internal mammary artery (RIMA)
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Great saphenous vein is unsuitable for use as a graft conduit;
* Subclavian artery stenosis or occlusion, or any contraindication to the use of the internal mammary artery as a graft conduit;
* History of previous cardiac surgery;
* Emergency surgery.
18 Years
ALL
No
Sponsors
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China National Center for Cardiovascular Diseases
OTHER_GOV
Responsible Party
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Locations
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Fuwai Hospital Chinese Academy of Medical Sciences
Beijing, , China
Peking University First Hospita
Beijing, , China
Qingdao Cardiovascular Hospital
Qingdao, , China
Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen
Shenzhen, , China
Countries
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Central Contacts
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Facility Contacts
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Chen
Role: primary
Wang
Role: primary
Feng
Role: primary
Nie
Role: primary
References
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Zhao DF, Edelman JJ, Seco M, Bannon PG, Wilson MK, Byrom MJ, Thourani V, Lamy A, Taggart DP, Puskas JD, Vallely MP. Coronary Artery Bypass Grafting With and Without Manipulation of the Ascending Aorta: A Network Meta-Analysis. J Am Coll Cardiol. 2017 Feb 28;69(8):924-936. doi: 10.1016/j.jacc.2016.11.071.
Tachibana H, Hiraoka A, Saito K, Naito Y, Chikazawa G, Tamura K, Totsugawa T, Yoshitaka H, Sakaguchi T. Incidence and impact of silent brain lesions after coronary artery bypass grafting. J Thorac Cardiovasc Surg. 2021 Feb;161(2):636-644. doi: 10.1016/j.jtcvs.2019.09.162. Epub 2019 Oct 16.
Other Identifiers
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2023ZD0504701
Identifier Type: -
Identifier Source: org_study_id