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Exercise Training and Vitamin D Metabolism

NCT ID: NCT07300332

Last Updated: 2025-12-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-11-10

Study Completion Date

2026-07-20

Brief Summary

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The prevalence of Vitamin D deficiency is significantly higher in adults with overweight/obesity compared to those with normal BMI. The "entrapment" of Vitamin D in adipose tissue due to impaired lipolytic stimulation and/or adipose tissue dysfunction has been proposed as the driving mechanism. Exercise training has been proposed as a promising strategy to increase mobilization of Vitamin D from adipose tissue, given its well described role in stimulating lipolysis. Indeed, a recent study revealed that participation in moderate-intensity cardiovascular type exercise over winter can mitigate the decline in 25-hydroxyvitamin D \[25(OH)D\] in adults with overweight/obesity, independent of weight loss. The aim of this study is to investigate the impact of hybrid-type high-intensity interval training over winter on vitamin D metabolism, in adults with overweight/obesity.

Detailed Description

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Thirty adults with overweight/obesity (both males and females) who will meet the inclusion criteria will be randomly assigned to either an Exercise group (n=15) or a Control group (n=15). The Exercise group will participate in three hybrid-type high-intensity interval training sessions per week over a 12-week period, while receiving a balanced diet. The Control group will receive a balanced diet but will not participate in exercise training. Both groups will provide a resting blood sample and undergo assessment of their body composition (via bioelectrical impedance analysis), daily dietary intake (via dietary recalls) and physical activity level (via accelerometry) at baseline (prior to intervention), 6 weeks and 12 weeks.

Conditions

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Obesity & Overweight Vitamin D

Keywords

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overweight obesity vitamin D 25-hydroxyvitamin D high-intensity interval training

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Exercise group

Exercise group will participate in three hybrid-type high-intensity interval training sessions per week over a 12-week period, while receiving a balanced diet

Group Type EXPERIMENTAL

Exercise training

Intervention Type OTHER

Receive a balanced diet and participate in three hybrid-type high-intensity interval training sessions per week over a 12-week period

Control group

Control group will receive a balanced diet but will not participate in exercise training

Group Type ACTIVE_COMPARATOR

Control

Intervention Type OTHER

Receive a balanced diet but abstain from any type of exercise training

Interventions

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Exercise training

Receive a balanced diet and participate in three hybrid-type high-intensity interval training sessions per week over a 12-week period

Intervention Type OTHER

Control

Receive a balanced diet but abstain from any type of exercise training

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* BMI = 25-35 kg/m2
* Absence of musculoskeletal injuries
* Absence of chronic health-related complications
* Non-smokers

Exclusion Criteria

* Consumption of Vitamin D supplements
* Consumption of anti-inflammatory drugs, statins and/or steroids
Minimum Eligible Age

35 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Thessaly

OTHER

Sponsor Role lead

Responsible Party

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Dimitrios Draganidis

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Dimitrios Draganidis, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Thessaly

Locations

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Department of Physical Education and Sport Science, University of Thessaly

Trikala, Karyes, Greece

Site Status RECRUITING

Countries

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Greece

Central Contacts

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Dimitrios Draganidis, PhD

Role: CONTACT

Phone: +302431047078

Email: [email protected]

Ioannis G Fatouros, PhD

Role: CONTACT

Phone: 2431047047

Email: [email protected]

Facility Contacts

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Athanasios Z Jamurtas, PhD

Role: primary

Ioannis G Fatouros, PhD

Role: backup

Other Identifiers

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UTH_2612_8.10.2025

Identifier Type: -

Identifier Source: org_study_id