Comparison of Amniotic Membrane Dressing and Aquacel®Ag for of Healing of Second-Degree Burns - A Randomized Controlled Trial.
NCT ID: NCT07300137
Last Updated: 2025-12-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ENROLLING_BY_INVITATION
NA
100 participants
INTERVENTIONAL
2025-09-20
2026-08-01
Brief Summary
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Our research will bridge the literature gap by comparing the efficacy of amniotic membrane and aqua cel dressing in management of second-degree burns. Aqua cel® Ag has been studied extensively for partial-thickness (second-degree) burns, but not directly against human amniotic membrane and as there's no RCT yet to compare these both treatment modalities.
The findings of this study will offer healthcare providers a dressing technique for burn patients that will minimize morbidity while also being cost effective in resource-limited countries
Detailed Description
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This study will aim to compare the efficacy of amniotic membrane dressing with Aqua cel® Ag (sodium carboxymethylcellulose silver dressing) in terms of healing in patients with second-degree burns.A randomized controlled trial will be conducted on patients with second-degree burns presenting within 72 hours involving ≤40% total body surface area (TBSA). Total 100 participants will be selected for this study by non-probability convenience sampling, randomized by computer generated method and divided into two groups Group A will receive dressings with an amniotic membrane, while Group B will be treated with Aqua Cel dressings. Dressings will be changed every 72 hours in Group A and whereas in Group B secondary dressing will be changed and reviewed for any soakage or gross contamination and will be continued until complete wound healing is achieved.
as per our hypothesis; amniotic membrane dressings will offer a clinically superior alternative to Aqua cel® Ag dressing in the management of second-degree burns, particularly in terms of healing time and patient comfort.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Amniotic membrane dressing group
application of preserved amniotic membrane dressing on second degree burns until healed
preserved amniotic membrane dressing
application of preserved human amniotic membrane as a biological dressing for second degree burn wounds
Aqua cel (Ag) dressing group
application of aqua cel dressing on second degree burns until healed
preserved amniotic membrane dressing
application of preserved human amniotic membrane as a biological dressing for second degree burn wounds
Interventions
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preserved amniotic membrane dressing
application of preserved human amniotic membrane as a biological dressing for second degree burn wounds
Eligibility Criteria
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Inclusion Criteria
* In patients/ OPD
* Fire Burn, Scald Burn, Flash Burn.
Exclusion Criteria
* Electrical \& Chemical Burns/
ALL
No
Sponsors
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Patel Hospital, Pakistan
OTHER
Responsible Party
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Shazra Khalid
Resident Plastic Surgery
Locations
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Patel hospital
Karachi, Sindh, Pakistan
Countries
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Study Documents
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Document Type: comparison between two types of dressings
View DocumentRelated Links
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Published article providing background information on the comparison of sodium carboxylic methyl-cellulose silver dressing versus standard petroleum gauze dressing for management of second-degree burns.
Other Identifiers
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RFC_024
Identifier Type: -
Identifier Source: org_study_id