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Quantitative Net Water Uptake as a Predictor of Functional Outcomes After Intravenous Thrombolysis in Acute Ischemic Stroke International Multicenter Observational Retrospective Study

NCT ID: NCT07299981

Last Updated: 2025-12-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2026-01-01

Study Completion Date

2027-07-01

Brief Summary

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While the effectiveness of intravenous thrombolysis (IVT) decreases over time, patients show considerable variability in how quickly their ischemic core progresses. Quantitative net water uptake (NWU) has emerged as a biomarker indicating blood-brain barrier disruption and may better reflect the "tissue clock" than time alone. Low NWU is associated with favorable outcomes, whereas high NWU predicts poor outcomes and futile recanalization. The study aims to determine whether NWU measured on initial non-contrast CT is a treatment effect modifier for the IVT therapy.

Detailed Description

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Conditions

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Ischemic Stroke

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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patients with ischemic stroke receiving IVT

No Interventions

Intervention Type OTHER

Not applicable as this is an observational, retrospective study.

Interventions

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No Interventions

Not applicable as this is an observational, retrospective study.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

Acute ischemic stroke treated with intravenous thrombolysis, Imaging with non-contrast cranial CT on admission, Follow-up imaging with non-contrast cranial CT or MRI 12-24 hours after IVT, final nfarct volume \> 5ml, ASPECT

Exclusion Criteria

Known use of oral anticoagulation (OAC) on admission, Preexisting ischemic infarction on admission non-contrast cranial CT, Patients with large vessel occlusion AIS who underwent mechanical thrombectomy, Low imaging quality precluding radiological measurements, Severe white matter lesions precluding radiological measurements, No ASPECTS
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sigmund Freud PrivatUniversitat

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Central Contacts

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Marek Sykora

Role: CONTACT

Phone: +431211215183

Email: [email protected]

Other Identifiers

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17803148

Identifier Type: -

Identifier Source: org_study_id