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Aerodigestive Fistulas in Adults at the University Hospital of Strasbourg

NCT ID: NCT07299513

Last Updated: 2025-12-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-11-21

Study Completion Date

2026-11-21

Brief Summary

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Acquired aerodigestive fistulas in adults are rare conditions, corresponding to a pathological communication between the digestive and respiratory tracts, requiring collaborative multidisciplinary management. Clinical manifestations are nonspecific, ranging from a simple cough to pulmonary sepsis, which can be life-threatening. Diagnosis is often multimodal, requiring radiological examinations and endoscopic investigations. The most frequent etiologies are divided into two groups: benign and malignant causes, each group representing 50% of all acquired aerodigestive fistulas. Among the benign etiologies, 75% are iatrogenic, mainly represented by complications related to orotracheal intubation. These fistulas of benign etiology most often have a favorable prognosis, amenable to surgical treatment. Conversely, the development of an aerodigestive fistula in the context of thoracic cancer marks a turning point in the evolution of the oncological disease. Indeed, the average life expectancy of patients with a malignant fistula is estimated at between 1 and 6 weeks without specific treatment. Following this palliative approach aimed at improving quality of life, multiple treatment options are available, often combined with digestive and thoracic endoscopy.

The Strasbourg University Hospitals are a leading tertiary care center for these pathologies, with departments of Pulmonology, Gastroenterology, Digestive Surgery, Thoracic Surgery, Medical Intensive Care, Multipurpose Surgical Intensive Care, Bronchial Endoscopy, and Digestive Endoscopy. The centre's influence extends over the entire eastern part of the Grand Est region (Nancy, Metz, Strasbourg, Mulhouse).

Detailed Description

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Conditions

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Aerodigestive Fistulas

Keywords

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Aerodigestive fistulas Endoscopic investigations Thoracic cancer Oncological disease Malignant fistula

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Age \> 18 years at diagnosis
* Diagnosis between January 1, 2014, and December 31, 2023
* Aerodigestive fistula defined by one of the following criteria:
* Fistula visualized by bronchoscopy and/or digestive endoscopy
* Fistula visualized by static chest imaging (CT scan or MRI)
* Fistula visualized by dynamic chest imaging (barium swallow)
* Hospitalization at the Strasbourg University Hospitals (HUS)

Exclusion Criteria

* Explicit refusal by the patient to provide their data
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Strasbourg, France

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Service de Pneumologie - Hôpitaux Universitaires de Strasbourg

Strasbourg, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Guillaume PAMART, MD

Role: CONTACT

Phone: 33 3/69/55/06/48

Email: [email protected]

Facility Contacts

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Guillaume PAMART, MD

Role: primary

Other Identifiers

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9376

Identifier Type: -

Identifier Source: org_study_id