ORCHARDS-AIR Study

NCT ID: NCT07298967

Last Updated: 2025-12-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

422 participants

Study Classification

INTERVENTIONAL

Study Start Date

2026-01-31

Study Completion Date

2026-06-30

Brief Summary

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The purpose of this observational study is to compare the effectiveness of air surveillance and to better understand the relationship between household transmission and viruses detected in the air.

Participants will provide nasal swabs and have an air sample surveillance device installed in their home.

Detailed Description

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The purpose of ORCHARDS-AIR is to utilize air surveillance in participant homes in conjunction with individually collected nasal specimens to assess their concordance and evaluate the significance of airborne detection with household transmission of common respiratory pathogens such as influenza and SARS-CoV-2.

The researchers postulate that households with documented and probable respiratory pathogen transmission will have higher rates of in-home air surveillance detection. Students with more severe illnesses will be absent more often and spend more time at home, potentially leading to absenteeism being associated with greater air surveillance detections and intrahousehold transmission.

Conditions

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Acute Respiratory Infection Influenza-like Illness

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Students with ARI (acute respiratoy infection)

Students with ARI and their household members will provide nasal swabs

Group Type EXPERIMENTAL

Nasal swab

Intervention Type DIAGNOSTIC_TEST

Participants will use a swab to collect nasal specimens

Indoor air quality monitor

Intervention Type DEVICE

InBio Apollo ambient air sampler to be run in the home for the duration of study participation. Material from the air, like aerosols, dust particles, and other environmental material, are collected on sampler filler material.

Interventions

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Nasal swab

Participants will use a swab to collect nasal specimens

Intervention Type DIAGNOSTIC_TEST

Indoor air quality monitor

InBio Apollo ambient air sampler to be run in the home for the duration of study participation. Material from the air, like aerosols, dust particles, and other environmental material, are collected on sampler filler material.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Student attends, or is eligible to attend, a school within the Oregon School District (OSD)
* Study has an illness characterized by at least 2 of 6 acute respiratory infection (ARI)/ILI symptoms (nasal discharge, nasal congestion, sneezing, sore throat, cough, fever) and student scores at least 2 points on the Jackson scale


* Live in the same household as eligible student participant
* Any age and gender
* Fluent in English
* Able to provide appropriate consent or assent

Exclusion Criteria

* Household member listed on Wisconsin Department of Corrections Sex Offender Registry
* Illness onset more than 7 days before anticipated time of specimen collection
* Anatomical defect for which nasal specimen collection is contraindicated
* Student participated too recently (\<7 days from day 14 during peak influenza / COVID-19 period and \<30 days during other times, as determined by a medically-attended surveillance program)
Minimum Eligible Age

4 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Wisconsin, Madison

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jonathan Temte, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Wisconsin, Madison

Locations

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University of Wisconsin-Madison

Madison, Wisconsin, United States

Site Status

Countries

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United States

Central Contacts

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Shari Barlow

Role: CONTACT

Phone: 608-265-4348

Email: [email protected]

Other Identifiers

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2025-1617

Identifier Type: -

Identifier Source: org_study_id

AS

Identifier Type: OTHER

Identifier Source: secondary_id

UWMSN | SMPH | DFMCH Departmen

Identifier Type: OTHER

Identifier Source: secondary_id

Protocol Version 12/15/2025

Identifier Type: OTHER

Identifier Source: secondary_id