MedDataX Logo

VR Stimulation of Exercise Response in Sedentary Humans

NCT ID: NCT07296991

Last Updated: 2025-12-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

48 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-09-30

Study Completion Date

2028-08-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Prolonged sedentary conditions contribute to declining health across human populations and cause significant secondary health consequences for many patients whose illnesses or injuries prevent them from exercising. The investigators have demonstrated that in a small animal fruit fly model, genetic stimulation of neurons that promote adrenergic signaling is sufficient to mimic the benefits of exercise training even in sedentary animals. The investigator's pilot work in humans has confirmed that humans respond to Virtual Reality (VR) stimuli that mimic exercise by increasing heart rate and altering heart rate variability in a way consistent with increased adrenergic activity.

In this study, the investigators will directly test for the first time whether repeated, controlled exposure to VR stimuli that induce adrenergic activity in sedentary humans can produce adaptive changes to protein expression and endurance performance like those produced by actual exercise in pre-diabetic participants with/without hypertension.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Prolonged Inactivity Metabolic Syndrome

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

Exercise metabolic syndrome insulin resistance virtual reality

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

EX-20 minutes sub max cycling exercise

20 minutes cycling exercise

Group Type ACTIVE_COMPARATOR

20 minutes cycling exercise

Intervention Type BEHAVIORAL

20 minutes cycling exercise

VR-virtual reality exercise

20 minutes virtual cycling

Group Type EXPERIMENTAL

Virtual Reality

Intervention Type BEHAVIORAL

20 minutes virtual cycling

VR+: 20 minutes sub max cycling exercise + virtual reality

20 minutes cycling exercise + 20 minutes virtual cycling

Group Type ACTIVE_COMPARATOR

20 minutes cycling exercise

Intervention Type BEHAVIORAL

20 minutes cycling exercise

Virtual Reality

Intervention Type BEHAVIORAL

20 minutes virtual cycling

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

20 minutes cycling exercise

20 minutes cycling exercise

Intervention Type BEHAVIORAL

Virtual Reality

20 minutes virtual cycling

Intervention Type BEHAVIORAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. Equal numbers male and female (32 each)
2. Blood glucose HbA1C: 5.7-6.4% or 100-125 mg/dL
3. BP: systolic\<120 and diastolic\<80 mmHg, systolic 120-129 mmHg and diastolic \<80 mmHg, or systolic \>130 mmHg and diastolic \>80 mmHg

Exclusion Criteria

1. BMI\>35kg/m2
2. Currently involved in an exercise program or similar activity
3. Taking medications that could affect results, including beta-blockers or SSRIs
4. Demonstrate any form of discomfort with the VR experience through self-reported feelings of anxiety or nausea
5. Alcohol consumption above a minimal level(\<2 oz/night)
6. BP: Systolic \>160 mmHg and Diastolic \>110 mmHg
Minimum Eligible Age

25 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

National Institute on Aging (NIA)

NIH

Sponsor Role collaborator

Wayne State University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Alyson Sujkowski

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Robert J Wessells, PhD

Role: PRINCIPAL_INVESTIGATOR

Wayne State University

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Wayne State University

Detroit, Michigan, United States

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

United States

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Alyson Sujkowski, PhD

Role: CONTACT

Phone: 419-461-4317

Email: [email protected]

Robert J Wessells, PhD

Role: CONTACT

Phone: 7344764325

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Alyson Sujkowski, PhD

Role: primary

Robert J Wessells, PhD

Role: backup

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

5R01AG059683-07

Identifier Type: NIH

Identifier Source: secondary_id

View Link

IRB-23-06-5927

Identifier Type: -

Identifier Source: org_study_id