International Genetic Obesity Registry

NCT ID: NCT07296900

Last Updated: 2025-12-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

5000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-11-17

Study Completion Date

2075-11-30

Brief Summary

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Genetic obesity results from changes in specific genes that affect appetite regulation, metabolism, and fat storage. Its severity and associated health issues vary depending on the genetic cause. In some cases, hormonal imbalances, developmental delays, or other complications may also occur. Identifying the genetic cause is essential for personalized treatment and understanding potential symptoms.

As genetic obesity is rare, specialists often encounter few patients with diverse genetic backgrounds and clinical features. Therefore, collecting global data is crucial to improve our understanding of the condition's progression, complications, and treatment responses for each genetic subtype.

To support this, the International Genetic Obesity Registry (iGO Registry) has been established to gather detailed patient information on genetic obesity. This registry will help advance research and improve clinical care for affected individuals. It will collect data from routine outpatient visits, focusing on relevant diagnostic and treatment information on an international level.

Detailed Description

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Conditions

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Genetic Obesity

Keywords

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genetic obesity patient registry monogenic obesity natural history

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Patients with

* genetically confirmed genetic obesity (ACMG classification 3-5, associated with obesity) and/or
* early onset severe obesity (BMI ≥ 120% 95th percentile or ≥ 35 kg/m2 before 5 years of age) if genetic testing was performed
* Capable of understanding the aims of the protocol and to provide informed consent (for children and chronically incapacitated individuals, consent is given by their legal guardians)

Exclusion Criteria

* Not capable of understanding the aims of the protocol and to provide informed consent
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Ulm

OTHER

Sponsor Role lead

Responsible Party

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Julia von Schnurbein

PD Dr. med.

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Ulm University Clinic

Ulm, , Germany

Site Status RECRUITING

Countries

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Germany

Central Contacts

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Julia von Schnurbein, PD Dr.

Role: CONTACT

Phone: 0049 731 500 57401

Email: [email protected]

Facility Contacts

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Julia von Schnurbein, PD Dr.

Role: primary

Other Identifiers

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iGO Registry

Identifier Type: -

Identifier Source: org_study_id