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Expert Consensus on the Use of Isotretinoin in Rejuvenation: A Delphi Study

NCT ID: NCT07296536

Last Updated: 2025-12-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Total Enrollment

15 participants

Study Classification

OBSERVATIONAL

Study Start Date

2026-01-25

Study Completion Date

2027-09-01

Brief Summary

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This expert consensus project explores the role of low-dose isotretinoin as a rejuvenative and preventive strategy for photoaging and sebaceous-driven skin changes. While isotretinoin is traditionally used for acne, increasing clinical experience suggests that carefully selected micro-dose and low-dose regimens may improve skin texture, pore size, sebaceous activity, and overall skin quality, with potential benefits in skin aging and maintenance rejuvenation programs.

Detailed Description

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This study is a non-interventional, Delphi-based expert consensus project designed to establish recommendations for the use of isotretinoin in skin rejuvenation. While isotretinoin is primarily indicated for acne, accumulating clinical evidence and practitioner experience suggest that low-dose or micro-dose regimens may contribute to improvements in skin texture, fine lines, pore size, sebaceous activity, and overall skin quality. However, standardized guidance on indications, dosing, treatment duration, monitoring, and safety precautions is limited.

A panel of expert dermatologists with practical experience in isotretinoin therapy and skin rejuvenation will be invited to participate in multiple iterative Delphi rounds. Experts will rate agreement with proposed statements using a structured Likert scale. After each round, anonymized feedback will be provided, and statements not reaching consensus will be revised and re-evaluated until stable agreement is achieved.

The final output will consist of consensus-based recommendations reflecting practical, safe, and evidence-informed guidance for dermatologists considering isotretinoin for rejuvenation purposes. The study will also identify areas of uncertainty where further research is needed, supporting the safe expansion of isotretinoin applications beyond acne management.

Conditions

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Isotretinoin Isotretinoin Adverse Reaction Rejuvenation

Keywords

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isotretinoin rejuvenation consensus delphi method Expert pannel

Study Design

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Observational Model Type

OTHER

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Expert Panel

A cohort of dermatology and aesthetic medicine experts participating in a Modified Delphi process to develop consensus recommendations on Isotretinoin in Rejuvenation.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Board-certified dermatologists or equivalent.

* 5 years clinical experience in dermatology.

Practical experience prescribing isotretinoin, including low- or micro-dose regimens for rejuvenation or acne.

Active engagement in clinical dermatology, teaching, research, or guideline development.

Willingness to participate in all Delphi rounds and provide informed consent.

Exclusion Criteria

* Non-dermatology specialists.

Less than 5 years of clinical experience.

Lack of relevant isotretinoin experience.

Significant undisclosed conflict of interest with isotretinoin manufacturers.

Inability to participate in all Delphi rounds.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Venus Research Center

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Venus Research Center

Cairo, , Egypt

Site Status

Countries

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Egypt

Other Identifiers

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Isotretinoin-Rejuvenation

Identifier Type: -

Identifier Source: org_study_id