Circulating Tumor Cell Counts in Postoperative ENE-Positive Oral Cavity Cancer Patients After Adjuvant CCRT
NCT ID: NCT07296250
Last Updated: 2025-12-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
100 participants
INTERVENTIONAL
2025-08-01
2028-07-31
Brief Summary
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Detailed Description
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This three-year study is expected to recruit 100 oral cavity cancer patients with extracapsular nodal extension (ENE) or other postoperative risks.10 mL of research blood was drawn four times in total.Each patient must continue to be tracked for ENE or other postoperative risks for one year, and with blood testing every tree month.
For the negative selection of CTCs by the negative selection system. For the positive selection of CTCs by counting Epithelial cell adhesion molecule(EpCAM)-positive and Hoechst-positive cells under a microscope with a hemocytometer.
In brief, CTC could predict a poor prognosis in HNSCC patients. But the role of longitudinal CTC follow-up in ENE+ oral cavity cancer patients remains unclear.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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control
participants without low-dose oral chemotherapy. Each patient must continue to be tracked for ENE or other postoperative risks for one year, and with blood testing every tree month.
No interventions assigned to this group
experimental
participants with low-dose oral chemotherapy. Each patient must continue to be tracked for ENE or other postoperative risks for one year, and with blood testing every tree month.
low-dose oral chemotherapy
recruit 100 oral cavity cancer patients with ENE or other postoperative risks.10 mL of research blood was drawn four times in total.Each patient must continue to be tracked for ENE or other postoperative risks for one year, and with blood testing every tree month.
Interventions
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low-dose oral chemotherapy
recruit 100 oral cavity cancer patients with ENE or other postoperative risks.10 mL of research blood was drawn four times in total.Each patient must continue to be tracked for ENE or other postoperative risks for one year, and with blood testing every tree month.
Eligibility Criteria
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Inclusion Criteria
1. Aged between 18 and 90 years.
2. Histologically confirmed diagnosis of head and neck squamous cell carcinoma (HNSCC).
3. Completed surgical treatment and identified as having high-risk factors, followed by concurrent chemoradiotherapy.
4. Willing to continue follow-up visits at the hospital after completion of treatment.
Exclusion Criteria
2. Deemed unsuitable for participation by the attending physician.
3. Unwilling to participate in the study.
18 Months
90 Years
ALL
Yes
Sponsors
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Chang Gung Memorial Hospital
OTHER
Responsible Party
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Chun-Ta Liao
Professor Attending Physicians
Principal Investigators
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ChunTa Liao, PhD
Role: PRINCIPAL_INVESTIGATOR
Division of Otolaryngology, Chang Gung Memorial Hospital
Locations
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Linkou Chang Gung Memorial Hospital
Taoyuan, , Taiwan
Countries
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Central Contacts
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Facility Contacts
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ChunTa Liao, PhD
Role: primary
ChiaHsun Hsieh, PhD
Role: backup
Other Identifiers
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202402125B0
Identifier Type: -
Identifier Source: org_study_id