Investigation of the ROle of faT and inflAmmaTory Cells in mElanoma
NCT ID: NCT07293598
Last Updated: 2025-12-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
20 participants
OBSERVATIONAL
2026-01-31
2027-01-31
Brief Summary
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This is a aims to validate the striking observation that a cross-talk between fat cells and leukocytes at the primary melanoma site promotes metastasis. In our unpublished pilot study, we have discovered an interesting finding whereby inflammatory cells extend from the tumour to and invading fat in the subcutaneous tissue and/or around the appendageal structures in the dermal skin in metastatic melanomas with distinct architectural changes within the fat. This finding was consistently present in metastatic and absent in non-metastatic melanomas. This new finding has both clinical and pathophysiological credence. Archival tissue blocks or human cell lines will be used in the first instance. As mitigation, experiments will be repeated with conditioned media obtained from co-culture of mixed primary immune cells obtained from peripheral blood mononuclear cell (PBMCs) and adipocytes induced from stem cells.
This study aims to:
* Investigate if the crosstalk between fat cells and tumour-infiltrating inflammatory cells defines the aggressiveness of primary cutaneous melanomas.
* Identify and perform biological spatial analysis of the inflammatory cells between the tumour and fat in the primary tumours.
* Investigate the interactions of fat cells and/or inflammatory cells in mediating melanoma cellular plasticity.
The patients have not provided consent and will be justified in this application
Detailed Description
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Conditions
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Study Design
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OTHER
RETROSPECTIVE
Interventions
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Sample analysis only
Sample analysis only
Eligibility Criteria
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Inclusion Criteria
2. Patients treated at the Christie between 2014 and 2019.
3. Review of histological slides for presence or absence of relevant histological features.
For group 3 and group 4:
4. Unique features of spitzoid melanomas
Exclusion Criteria
* Unable to view the entire cross section of the skin with the primary tumour hence, unable to assess the invasion of inflammatory cells into fat
ALL
No
Sponsors
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University of Manchester
OTHER
The Christie NHS Foundation Trust
OTHER
Responsible Party
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Locations
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The Christie NHS Foundation Trust
Manchester, , United Kingdom
Countries
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Central Contacts
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Facility Contacts
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Richa Garva, Dr
Role: primary
Other Identifiers
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CFTSp252
Identifier Type: -
Identifier Source: org_study_id