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tDCS as Treatment for Motor Function

NCT ID: NCT07291687

Last Updated: 2025-12-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-10-30

Study Completion Date

2030-12-31

Brief Summary

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Previous preliminary results are sufficiently impressive to suggest that tDCS stimulation does have the potential to improve motor function when that ability is trained during stimulation. In the proposed study, the investigation will assess whether walking sessions combined with tDCS lead to improvements in motor function: gait, articulation, eye gaze, and motor dexterity. In addition, the investigators wish to examine if such results can be replicated in people with other conditions, such as cortical basal syndrome, and Parkinson's disease.

Detailed Description

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Previous preliminary results are sufficiently impressive to suggest that tDCS stimulation does have the potential to improve motor function when that ability is trained during stimulation. In the proposed study, the investigators will assess whether walking sessions combined with tDCS lead to improvements in motor function: gait, articulation, eye gaze, and motor dexterity. In addition, the investigators wish to examine if such results can be replicated in people with other conditions, such as cortical basal syndrome, and Parkinson's disease. The rationale for including people living with these conditions is the overlap in motor and cortical network dysfunction observed across these disorders. All three conditions involve impairment of motor initiation, gait, coordination, and executive motor control due to degeneration in frontal-subcortical pathways. This extension will also allow for comparison of stimulation responsiveness across related diagnostic groups and provide insight into disease-specific factors influencing motor recovery potential.

Previous tDCS studies have found significant results with sample sizes between 10-20 participants for a two-round study comparing training sessions with real tDCS versus sessions done without tDCS. However, the investigators plan to recruit 30 participants living with each condition as this will allow us to examine results per group, but also how the individual groups compare.

Conditions

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Progressive Supranuclear Palsy Cortical Basal Ganglionic Degeneration Parkinson Disease

Keywords

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Progressive Supranuclear Palsy (PSP), Cortical basal syndrome (CBD)

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

The study is a Longitudinal A-B-A study with alternating between real (A) and sham sessions (B).
Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Outcome Assessors

Study Groups

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Real tDCS Stimulation:

Participants will be exposed to 20 min of tDCS brain stimulation while undergoing training on cognitive tasks.

Group Type EXPERIMENTAL

Transcranial direct current stimulation (TDCS)

Intervention Type DEVICE

The Crossover design will enable us to use each participant as their own control.

Sham Arm

Participants will be exposed to 20 min of tDCS sham/placebo stimulation while undergoing training on cognitive tasks. Participants will have the exact same apparatus used but with no stimulation.

Group Type PLACEBO_COMPARATOR

Stimulation Arm

Intervention Type DEVICE

Participants will be exposed to the brain stimulation protocol while undergoing certain motor task during the training sessions.

Interventions

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Transcranial direct current stimulation (TDCS)

The Crossover design will enable us to use each participant as their own control.

Intervention Type DEVICE

Stimulation Arm

Participants will be exposed to the brain stimulation protocol while undergoing certain motor task during the training sessions.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

\- 1. Participants must be able to walk unassisted, or with the assistance of a walker or cane, and be individuals who walk daily.

2\. Participants should have a sufficient level of English to be able to express themselves verbally, be able to read and follow instructions.

Exclusion Criteria

* 3\. Individuals with metal implants within the brain such as shunts will be excluded.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Baycrest

OTHER

Sponsor Role lead

Responsible Party

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Tyler Roncero

Principle Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Tyler Roncero, Ph.D

Role: PRINCIPAL_INVESTIGATOR

Baycrest Academy of Health Sciences and Geriatric Research

Howard Chertkow, MD

Role: PRINCIPAL_INVESTIGATOR

Baycrest Academy of Health Sciences and Geriatric Research

Locations

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Baycrest Academy of Health Sciences and Geriatric Research

Toronto, Ontario, Canada

Site Status RECRUITING

Countries

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Canada

Central Contacts

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Alice Zhang, B.Sc

Role: CONTACT

Phone: (416) 785-2500

Email: [email protected]

Tyler Roncero, Ph.D

Role: CONTACT

Phone: T (416) 785-2500

Email: [email protected]

Provided Documents

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Document Type: Study Protocol

View Document

Other Identifiers

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21-17

Identifier Type: -

Identifier Source: org_study_id