Optimizing Strategies to Maximize Patient Recruitment Yield
NCT ID: NCT07290335
Last Updated: 2025-12-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
100000 participants
INTERVENTIONAL
2025-12-31
2027-04-30
Brief Summary
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Detailed Description
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In recent years, researchers have begun to leverage patient portals and electronic health records (EHRs) for recruitment. This method allows for engagement of broad populations within a health system in a cost-effective way. Emerging evidence of EHR recruitment shows promise. The researchers of this study have examined the use of EHR recruitment to identify and contact eligible patients via MyChart direct-to-patient messaging across a range studies within Emory Healthcare. Having completed a pilot program within the Emory system, this service is now available to all Emory investigators for whom MyChart recruitment is appropriate.
While the feasibility of MyChart messaging has been documented, little is known about best practices for how recruitment messages should be designed. There are, however, good reasons to believe that how messages are designed and framed may impact potential participants' responses to them.
This project is a platform trial that will allow for serial testing of various aspects of portal-based messaging. Consistent with platform trial design, the researchers will use a common set of outcome measures across various studies, and the portal-based messaging strategy allows for easy randomization (generally at the patient level) of patients to specific messaging approaches.
In the context of broader use of MyChart messaging, the researchers have designed this study to examine the impact of message design on patients' responses. Specifically, this study will examine the impact of including positively-valenced language that describes the value of the study and the impact of inclusion of information regarding any payments that participants will receive in the study. Both of these factors are ones that are grounded in behavioral economics and may be meaningful to potential participants.
The first proposed trial will involve randomly assigning patients who are identified as potentially eligible for studies using the MyChart recruitment mechanism to receive a recruitment message using 1 of 4 templates: 1) the current standard template; 2) a template with inclusion of positively-valenced language describing the study's value; 3) a template containing information about payment to participants; and 4) a template with both positively-valenced language and payment information. For all studies using the MyChart mechanism, all 4 messages will be created, and assignment will be done based on the last two digits of the patient's medical record number (MRN).
The primary endpoint is the rate at which individuals respond that they are interested in participating in the study to which they are invited. Additionally, this study will examine the non-response rate and the rate of individuals responding that they are not interested in the study. It will also track the rate at which individuals exposed to a MyChart recruitment message change their permission settings for contact about research opportunities. Study teams whose study invitations are used in this trial will be contacted about the rate of enrollment among patients who responded as "interested" to the message so that the researchers can estimate enrollment rate within each intervention group. Finally, select patients will participate in short interviews to understand their impressions of the message they were sent and their attitudes towards research more generally.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
HEALTH_SERVICES_RESEARCH
NONE
Study Groups
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Baseline (control) message
Patients in the Emory Healthcare system, who have not opted out of research contact, receiving MyChart messaging for research recruitment using the current standard template.
Baseline (control) message
The MyChart study recruitment program will send a message based on the current template, which is a brief message with a neutral tone.
Positively-valenced message
Patients in the Emory Healthcare system, who have not opted out of research contact, receiving MyChart messaging for research recruitment using a template with inclusion of positively-valenced language describing the study's value.
Positively-valenced message
The MyChart study recruitment program will send a message based on a template that contains positively-valenced language related to the value/importance of the study.
Payment-inclusive message
Patients in the Emory Healthcare system, who have not opted out of research contact, receiving MyChart messaging for research recruitment using a template containing information about payment to participants.
Payment-inclusive message
The MyChart study recruitment program will send a message based on a template that includes more detailed information about participant payment.
Positively-valenced, payment-inclusive message
Patients in the Emory Healthcare system, who have not opted out of research contact, receiving MyChart messaging for research recruitment using a template with both positively-valenced language and payment information.
Positively-valenced, payment-inclusive message
The MyChart study recruitment program will send a message based on a template that includes both positively-valenced language and detailed information about participant payment.
Interventions
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Baseline (control) message
The MyChart study recruitment program will send a message based on the current template, which is a brief message with a neutral tone.
Positively-valenced message
The MyChart study recruitment program will send a message based on a template that contains positively-valenced language related to the value/importance of the study.
Payment-inclusive message
The MyChart study recruitment program will send a message based on a template that includes more detailed information about participant payment.
Positively-valenced, payment-inclusive message
The MyChart study recruitment program will send a message based on a template that includes both positively-valenced language and detailed information about participant payment.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criterion for primary studies that are recruiting participants:
* Not using MyChart for recruitment.
* At least 500 messages sent, 125 for each arm
* All patients receiving messages via MyChart will be included
* Potential eligibility for a study using MyChart requirement based on the planned query/criteria for that study.
Exclusion Criteria
* Excluded from primary study that is recruiting participants.
18 Years
ALL
No
Sponsors
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American Heart Association
OTHER
Georgia Clinical and Translational Science Alliance (GaCTSA)
UNKNOWN
National Center for Advancing Translational Sciences (NCATS)
NIH
Emory University
OTHER
Responsible Party
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Neal Dickert
Professor
Principal Investigators
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Neal Dickert, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Emory University
Locations
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Emory Healthcare System
Atlanta, Georgia, United States
Countries
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Central Contacts
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Other Identifiers
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2025P013508
Identifier Type: -
Identifier Source: org_study_id