Correlation Between Diagnostic Nerve Block Response and Cryoneurolysis Outcome in Chronic Musculoskeletal Disorders and Spasticity
NCT ID: NCT07289984
Last Updated: 2025-12-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
50 participants
INTERVENTIONAL
2026-02-01
2031-08-01
Brief Summary
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Purpose of the Study:
The overarching purpose of the CRYONIC PROTOCOL study is to assess the Correlation Between Diagnostic Nerve Block Response and Cryoneurolysis Outcome in Chronic Musculoskeletal Disorders and Spasticity. The study focuses on evaluating the effectiveness of ultrasound-guided peripheral nerve cryoneurolysis, a minimally invasive technique that uses extreme cold to induce temporary nerve blocks, for patients with treatment-resistant chronic musculoskeletal pain and spasticity.
The study also seeks to determine if cryoneurolysis itself leads to meaningful improvements in both pain intensity and functional ability in the included patient cohorts (those with chronic musculoskeletal pain or spasticity)
Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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Chronic musculoskeletal pain group
cryoablation
Cryoneurolysis
Interventions
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cryoablation
Cryoneurolysis
Eligibility Criteria
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Inclusion Criteria
* Adults (\> 18y) with either chronic musculoskeletal pain (\> 3 months; average NRS \> 5/10) or painful/functionally limiting spasticity
* Have a clinical stable condition, \> 3months
* Any medications must be maintained on a stable schedule- Able to understand study instructions and provide informed consent (ICF) in French or Dutch.Provide written informed consent
Exclusion Criteria
* Patient's refusal to give consent to the procedure or to use of their data for research purposes.
* Ongoing local or systemic infection before the procedure.
* Predominantly neuropathic pain of the upper extremity as assessed with the Pain Detect questionnaire
18 Years
ALL
No
Sponsors
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Universitair Ziekenhuis Brussel
OTHER
Responsible Party
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Other Identifiers
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25428
Identifier Type: OTHER
Identifier Source: secondary_id
UniversitairZB25428
Identifier Type: -
Identifier Source: org_study_id