The Benefits of Wearable AI in Post-Discharge Management of AMI Patients

NCT ID: NCT07288229

Last Updated: 2025-12-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-12-30

Study Completion Date

2026-12-30

Brief Summary

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Myocardial infarction (MI) remains a major threat to human health. Although interventional treatment techniques have advanced rapidly, many patients still experience major adverse cardiovascular events (MACE) and require hospital readmission after discharge. Artificial intelligence (AI) based on wearable device data has shown great potential in the diagnosis and management of cardiovascular diseases.

This study aims to explore the clinical value of wearable device-based data analysis and AI-driven risk stratification models in post-discharge management of acute myocardial infarction (AMI) patients.

Detailed Description

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This prospective, open-label, randomized controlled study aims to evaluate the clinical benefits of wearable device-based AI risk models in post-discharge management of AMI patients. A total of 200 patients who have undergone PCI and provided informed consent will be enrolled, including those with both preserved and reduced left ventricular ejection fraction (LVEF).

Participants will be randomly assigned to either the control group or the intervention group in a 1:1 ratio. All patients will be equipped with a wearable smartwatch and continuously monitored for 3 months after discharge. Data collected will include physiological signals, sleep and activity parameters. In both groups, patients will receive weekly telephone follow-ups and monthly office visits to record symptoms, medication use, and adverse events.

In the intervention group, wearable data and AI analytical results will be made available to both patients and their physicians. These insights will be discussed during follow-ups and used to support lifestyle modification, medication adjustment, and clinical decision-making. In the control group, AI data will be collected but not shared or used for clinical management during the study period.

The primary study endpoint is the time to first unplanned hospital readmission within 3 months, including readmissions due to chest pain, heart failure, arrhythmia, recurrent myocardial infarction, or death. The secondary endpoints include: Change in Kansas City Cardiomyopathy Questionnaire-12 (KCCQ-12) score from baseline to 3 months; change in left ventricular ejection fraction (LVEF) measured by echocardiography between baseline and 3 months.

The investigators hypothesize that AI-assisted, wearable-based monitoring and feedback will improve early detection of adverse cardiovascular events, reduce unplanned hospitalizations, increase LVEF in patients with reduced LVEF at discharge, and enhance quality of life compared with standard post-discharge care.

Conditions

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Acute Myocardial Infarction Heart Failure

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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The guideline-guided traditional management group

As the control group, wearable data will be collected but not shared with the participant and responding physician or used for clinical management during the study period. All management in the participants is based on updated clinical guidelines.

Group Type NO_INTERVENTION

No interventions assigned to this group

The guideline-guided and wearable-assisted management group

As the intervention group, in addition to clinical guidelines, wearable data and AI analytical results will be made available to both patients and their physicians. These insights will be discussed during follow-ups and used to support lifestyle modification, medication adjustment, and clinical decision-making.

Group Type EXPERIMENTAL

Optimized Integrated Management Based on AI-Guided Wearable Data

Intervention Type COMBINATION_PRODUCT

The collected data will be shared with both patients and their treating physicians during follow-up visits. Based on these insights, the clinical team will offer personalized recommendations regarding medication adjustment, lifestyle modification, diet optimization, and physical activity guidance.

Interventions

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Optimized Integrated Management Based on AI-Guided Wearable Data

The collected data will be shared with both patients and their treating physicians during follow-up visits. Based on these insights, the clinical team will offer personalized recommendations regarding medication adjustment, lifestyle modification, diet optimization, and physical activity guidance.

Intervention Type COMBINATION_PRODUCT

Eligibility Criteria

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Inclusion Criteria

* Adults aged 18 to 75 years.
* Confirmed diagnosis of acute myocardial infarction (AMI), including both ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI).
* Underwent successful percutaneous coronary intervention (PCI) during index hospitalization.
* Hemodynamically stable at the time of hospital discharge.
* Willing and able to wear a smartwatch continuously for the study period.
* Compatible with the data collection application and have stable internet access.

Exclusion Criteria

* Planned staged or elective PCI or any coronary revascularization scheduled within 3 months after discharge.
* Unable to tolerate or contraindicated for wearing metal or electronic monitoring devices.
* Pregnant or breastfeeding women.
* Residence in an area without stable network connectivity or inability to use a smartphone for data upload and communication.
* Severe comorbidities that limit 3-month survival or follow-up.
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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RenJi Hospital

OTHER

Sponsor Role lead

Responsible Party

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Zhiguo Zou

Doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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ZHIGUO ZOU, MD, PhD

Role: CONTACT

Phone: +86 13524596108

Email: [email protected]

Other Identifiers

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EARLY-MYO Wearable AI

Identifier Type: -

Identifier Source: org_study_id