Effect of Cold Atmospheric Plasma on Patient Comfort During Dental Anesthesia
NCT ID: NCT07288125
Last Updated: 2025-12-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
30 participants
INTERVENTIONAL
2025-09-01
2025-11-03
Brief Summary
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In this study, to help reduce the pain felt during the dental injection, some patients will receive a cold plasma application before the needle is administered. The device is held close to the gum area where the injection will be given-without touching the tissue-for about one minute to help the area relax. Afterwards, the standard local anesthetic injection is performed. On the opposite side of the mouth, only the normal injection will be given. Pain levels on both sides and patient satisfaction will be recorded through questions asked after the procedure.
If you choose to participate in this research, your dental treatments will still be completed, and the pain felt during the injection may be reduced. Additionally, by participating, you will contribute to scientific knowledge and to the development of a potential future treatment option.
Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
CROSSOVER
OTHER
NONE
Study Groups
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Control
No pretreatment, standard injection only
No pretreatment
No pretreatment is applied. The control side receives only the standard buccal local infiltration anesthesia.
CAP
Cold Atmospheric Plasma applied before injection
Cold Atmospheric Plasma
Cold atmospheric plasma is applied to the oral mucosa at the planned injection site for 30 seconds using a non-contact atmospheric plasma device before local infiltration anesthesia.
Interventions
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Cold Atmospheric Plasma
Cold atmospheric plasma is applied to the oral mucosa at the planned injection site for 30 seconds using a non-contact atmospheric plasma device before local infiltration anesthesia.
No pretreatment
No pretreatment is applied. The control side receives only the standard buccal local infiltration anesthesia.
Eligibility Criteria
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Inclusion Criteria
* American Society of Anesthesiologists (ASA) physical status classification I (systemically healthy);
* No known allergy or intolerance to local anesthetic agents or cold atmospheric plasma (CAP);
* Presence of similar bilateral dental treatment indications in the maxilla or mandible.
Exclusion Criteria
* Presence of active lesions, ulceration, or signs of infection in the mucosa at the injection site;
* Immunodeficiency or systemic immunosuppressive therapy;
* Use of anticoagulant medications;
* Previous exposure to CAP therapy for any purpose;
* History of allergy to local anesthetic agents;
* Presence of neurological or psychiatric disorders that may affect pain perception.
18 Years
40 Years
ALL
Yes
Sponsors
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Kahramanmaras Sutcu Imam University
OTHER
Responsible Party
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Izzet Acikan
Assistant Professor
Locations
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Kahramanmaras Sutcu Imam University, Faculty of Dentistry
Kahramanmaraş, , Turkey (Türkiye)
Countries
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References
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Jagtap B, Bhate K, Magoo S, S N S, Gajendragadkar KS, Joshi S. Painless injections-a possibility with low level laser therapy. J Dent Anesth Pain Med. 2019 Jun;19(3):159-165. doi: 10.17245/jdapm.2019.19.3.159. Epub 2019 Jun 30.
Ucar G, Sermet Elbay U, Elbay M. Effects of low level laser therapy on injection pain and anesthesia efficacy during local anesthesia in children: A randomized clinical trial. Int J Paediatr Dent. 2022 Jul;32(4):576-584. doi: 10.1111/ipd.12936. Epub 2022 Feb 8.
Other Identifiers
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Harran university HRÜ/25.13.39
Identifier Type: -
Identifier Source: org_study_id