Comparison Between Platelet Rich Plasma and Nanofat as an Adjuvant Therapy in HairTransplantation

NCT ID: NCT07287579

Last Updated: 2025-12-17

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 30 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2026-01-31
• Study Completion Date: 2027-12-31

Brief Summary

• To compare the efficacy of platlet rich plasma and Nanofat injection as adjuvant therapies with FUE hair transplantation in improving graft survival rate,
• To measure hair density and thickness postoperatively using dermoscopy or trichoscopy.
• To evaluate patient satisfaction and photographic assessment by blinded evaluators.
• To assess any adverse effects or complications related to each modality

Detailed Description

• Ideal candidates for hair transplantation typically present with a clear, stable pattern of hair loss, characterized by at least 50% thinning or balding in 1 or more areas. The scalp must be healthy, with donor hair of good quality and quantity. Patients must have realistic expectations and be free of medical conditions that compromise surgical outcomes. The safe donor zone is located in the mid-occipital region between the upper and lower occipital protuberances, typically containing 65 to 85 follicular units/cm²
• Intra-operative injection of PRP is beneficial in giving faster density, reducing the catagen loss of transplanted hair, early recovery of the skin, the faster appearance of new anagen hair in FUE hair transplantation.
• This study compares the effects of PRP and Nano fat as adjuvants in Androgenic alopecia patients undergoing FUE hair transplantation.
• Nanofat contain stem cells supposed to improve the results of FUE hair transplantation , but the question that we hope to answer at the end of our study which one we recommend as an adjuvant therapy PRP or Nano fat?

Conditions

Androgenic Alopecia

Keywords

hair transplantation

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

group a

hair transplantation done alone without platelet rich plasma or nanofat injection

Group Type: EXPERIMENTAL

hair transplantation

Intervention Type: PROCEDURE

we compare the effect of nanofat injection and platelet rich plasma in hair transplantation in male androgenic alopecia

group b

we do injection of platelet rich plasma with hair transplantation

Group Type: EXPERIMENTAL

hair transplantation

Intervention Type: PROCEDURE

we compare the effect of nanofat injection and platelet rich plasma in hair transplantation in male androgenic alopecia

group c

we do injection of nanofat with hair transplantation

Group Type: EXPERIMENTAL

hair transplantation

Intervention Type: PROCEDURE

we compare the effect of nanofat injection and platelet rich plasma in hair transplantation in male androgenic alopecia

Interventions

hair transplantation

we compare the effect of nanofat injection and platelet rich plasma in hair transplantation in male androgenic alopecia

Intervention Type: PROCEDURE

Other Intervention Names

hair transplantation with platelet rich plasma; hair transplantation with nanofat injection

Eligibility Criteria

Inclusion Criteria

• 1. Male patients with stable androgenic alopecia more than 2 years. 2. Age 20-50 years 3. No recent medical hair loss treatments.

Exclusion Criteria

• 1. Active scalp infections or scarring alopecia. 2. Systemic diseases affecting wound healing. 3. Platelet disorders or anticoagulant use. 4. Smoking or heavy alcohol intake

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: No

Sponsors

Sohag University

OTHER

Sponsor Role: lead

Responsible Party

Shenoda Gamel Fayez

Assistant lecturer in plastic surgery department, faculty of medicine Sohag University hospital.

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

samia saied, MD

Role: STUDY_CHAIR

Sohag University

Central Contacts

shenouda Faiez, AL

Role: CONTACT

Phone: 0201285122844

Email: shenoda011111@med.sohag.edu.eg

mostafa haredy, MD

Role: CONTACT

Phone: 0201095159392

Email: mostafaharedy84@gmail.com

References

Evin N, Guray Evin S. Camouflage of Postburn Scarring Alopecia Using Nanofat Grafting and Follicular Unit Hair Transplantation. Plast Reconstr Surg. 2024 Jul 1;154(1):207-215. doi: 10.1097/PRS.0000000000010759. Epub 2023 May 26.

Reference Type: BACKGROUND

PMID: 37253046 (View on PubMed)

Provided Documents

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Related Links

https://pubmed.ncbi.nlm.nih.gov/27761085/

Outcome of Intra-operative Injected Platelet-rich Plasma Therapy During Follicular Unit Extraction Hair Transplant: A Prospective Randomised Study in Forty Patients

Other Identifiers

Soh-Med--25-11-1MD

Identifier Type: -

Identifier Source: org_study_id