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Evaluation of the Variation Over Time of Visuospatial Deficit in Patients With Parietal Lobe Glioma

NCT ID: NCT07286929

Last Updated: 2025-12-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-12-03

Study Completion Date

2026-10-31

Brief Summary

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The goal of modern neurooncological surgery is to obtain maximum tumor resection while preserving neurological function. Parietal lobe gliomas often cause attention deficits (hemineglect) that are difficult to differentiate from other deficits. This study aims to evaluate the extent and variation over time of visuo-spatial deficits in patients undergoing surgical removal of parietal lobe gliomas. This will help characterize the cognitive profile of these patients to identify personalized treatment and rehabilitation paths.

Detailed Description

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This is a single-centre, prospective, cross-sectional, observational study involving 40 patients with high- and low-grade parietal lobe glioma. The study investigates the prevalence of subjects who show a performance in cognitive visuo-spatial tests below the cut-off of the normative sample. It evaluates associations with patient-reported outcome measures (ADL, IADL), clinical-demographic aspects, radiological data (MRI), and histological/molecular data. Assessments occur at screening (pre-surgery), and at follow-up visits (3-4 months and 6 months post-surgery). Neuropsychological tests include Line Bisection, Bell and Letter Cancellation, Reading test, Apple Cancellation, and Fluff test.

Conditions

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Glioma Parietal Lobe Glioma Visuspatial Deficit Unilateral Spatial Neglect (USN)

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Patients \>18 years old
* Patients must understand the Italian Language
* Patients with suspected parietal lobe glioma

Exclusion Criteria

* Tumor site other than parietal lobe.
* Patients who cannot undergo surgical resection (stereotactic/open biopsy).
* Patients who received a previous chemotherapy and/or radiotherapy treatment.
* Patients with a history of intracranial mass lesion or traumatic brain injury.
* Patients with a history of other CNS diseases (e.g., stroke, metastasis).
* Patients with diagnosis of neurodegenerative disease (i.e. Alzheimer's Disease, Frontotemporal Dementia, Parkinson's Disease, Lewy Body Dementia, Amyotrophic Lateral Sclerosis).
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Francesco Di Meco, MD

Role: PRINCIPAL_INVESTIGATOR

Fondazione IRCCS Istituto Neurologico Carlo Besta

Locations

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Fondazione IRCCS Istituto Neurologico Carlo Besta

Milan, , Italy

Site Status RECRUITING

Countries

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Italy

Central Contacts

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Francesco Di Meco, MD

Role: CONTACT

[email protected]
+ 39 02.2394

Facility Contacts

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Francesco Di Meco, MD

Role: primary

[email protected]
+ 39 02.2394

Other Identifiers

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neGLIO

Identifier Type: -

Identifier Source: org_study_id