A Study of KarXT + KarX-EC for Treatment of Irritability in Children and Adolescents With Autism

NCT ID: NCT07284745

Last Updated: 2026-01-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

PHASE3

Total Enrollment

176 participants

Study Classification

INTERVENTIONAL

Study Start Date

2026-02-27

Study Completion Date

2026-07-05

Brief Summary

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The purpose of this study is to assess KarXT + KarX-EC for the treatment of irritability associated with autism in children and adolescents.

Detailed Description

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Conditions

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Irritability Associated With Autism Spectrum Disorder

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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KarXT + KarX-EC Arm

Group Type EXPERIMENTAL

KarXT

Intervention Type DRUG

Specified dose on specified days

KarX-EC

Intervention Type DRUG

Specified dose on specified days

Placebo

Group Type PLACEBO_COMPARATOR

KarXT + KarX-EC Matching Placebo

Intervention Type DRUG

Specified dose on specified days

Interventions

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KarXT

Specified dose on specified days

Intervention Type DRUG

KarX-EC

Specified dose on specified days

Intervention Type DRUG

KarXT + KarX-EC Matching Placebo

Specified dose on specified days

Intervention Type DRUG

Other Intervention Names

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BMS-986510 Xanomeline/Trospium Chloride BMS-986519 Xanomeline Enteric-coated

Eligibility Criteria

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Inclusion Criteria

* Participants must have a confirmed diagnosis of ASD, as defined by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR) criteria, confirmed by the K-SADS-PL and must be experiencing symptoms of irritability.
* Participants must have ABC-I ≥18 (C18 on the Irritability subscale of the ABC-I) and CGIS specific to irritability ≥4, at screening and baseline (Day 1).

Exclusion Criteria

* Participants must not have a current primary DSM-5 diagnosis of bipolar disorder, including bipolar II disorder, schizophrenia, schizoaffective disorder, major depressive episode as determined by clinical instrument, or post-traumatic stress disorder (PTSD).
* Exception Include: Participants with comorbid ADHD, provided that attention deficit/hyperactivity disorder (ADHD) is not the primary disorder, the participant is adequately treated and based on the investigator judgment the disorder is clinically stable.
* Participants must not have history/presence of clinically significant disease or disorder that would jeopardize participant safety or validity of study results.
* Participants must not have a risk for suicidal behavior, and any clinically significant abnormal laboratory test.
Minimum Eligible Age

5 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Bristol-Myers Squibb

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bristol-Myers Squibb

Role: STUDY_DIRECTOR

Bristol-Myers Squibb

Locations

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Local Institution - 0036

Dothan, Alabama, United States

Site Status

Local Institution - 0236

Phoenix, Arizona, United States

Site Status

Local Institution - 0031

Anaheim, California, United States

Site Status

Local Institution - 0092

Chino, California, United States

Site Status

Local Institution - 0257

Glendale, California, United States

Site Status

Local Institution - 0181

San Rafael, California, United States

Site Status

Local Institution - 0252

Colorado Springs, Colorado, United States

Site Status

Local Institution - 0256

Hartford, Connecticut, United States

Site Status

Local Institution - 0264

Boca Raton, Florida, United States

Site Status

Local Institution - 0099

Gainesville, Florida, United States

Site Status

Local Institution - 0278

Gainesville, Florida, United States

Site Status

Local Institution - 0155

Peachtree Corners, Georgia, United States

Site Status

Local Institution - 0160

Bloomfield Hills, Michigan, United States

Site Status

Local Institution - 0220

Detroit, Michigan, United States

Site Status

Local Institution - 0110

Las Vegas, Nevada, United States

Site Status

Local Institution - 0246

Staten Island, New York, United States

Site Status

Local Institution - 0263

The Bronx, New York, United States

Site Status

Local Institution - 0247

West Chester, Ohio, United States

Site Status

Local Institution - 0269

Danville, Pennsylvania, United States

Site Status

Local Institution - 0105

Pittsburgh, Pennsylvania, United States

Site Status

Local Institution - 0041

Dallas, Texas, United States

Site Status

Local Institution - 0266

Fort Worth, Texas, United States

Site Status

Local Institution - 0273

Fort Worth, Texas, United States

Site Status

Local Institution - 0185

Spring, Texas, United States

Site Status

Local Institution - 0074

Bountiful, Utah, United States

Site Status

Local Institution - 0271

Provo, Utah, United States

Site Status

Local Institution - 0260

Richmond, Virginia, United States

Site Status

Local Institution - 0046

La Plata, Buenos Aires, Argentina

Site Status

Local Institution - 0048

Buenos Aires, Buenos Aires F.D., Argentina

Site Status

Local Institution - 0047

Córdoba, , Argentina

Site Status

Local Institution - 0288

Córdoba, , Argentina

Site Status

Local Institution - 0049

Mendoza, , Argentina

Site Status

Local Institution - 0140

Santiago del Estero, , Argentina

Site Status

Local Institution - 0010

Westmead, New South Wales, Australia

Site Status

Local Institution - 0007

Brisbane, Queensland, Australia

Site Status

Local Institution - 0045

Melbourne, Victoria, Australia

Site Status

Local Institution - 0286

Melbourne, Victoria, Australia

Site Status

Local Institution - 0136

Edmonton, Alberta, Canada

Site Status

Local Institution - 0134

Hamilton, Ontario, Canada

Site Status

Local Institution - 0135

Kingston, Ontario, Canada

Site Status

Local Institution - 0205

Toronto, Ontario, Canada

Site Status

Local Institution - 0187

Montreal, Quebec, Canada

Site Status

Local Institution - 0056

Kozhikode, Kerala, India

Site Status

Local Institution - 0061

Nagpur, Maharashtra, India

Site Status

Local Institution - 0218

Kolkata, West Bengal, India

Site Status

Countries

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United States Argentina Australia Canada India

Central Contacts

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BMS Study Connect www.BMSStudyConnect.com

Role: CONTACT

8559073286

First line of the email MUST contain the NCT# and Site#

Role: CONTACT

Facility Contacts

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Site 0036

Role: primary

Site 0236

Role: primary

Site 0031

Role: primary

Site 0092

Role: primary

Site 0257

Role: primary

Site 0181

Role: primary

Site 0252

Role: primary

Site 0256

Role: primary

Site 0264

Role: primary

Site 0099

Role: primary

Site 0278

Role: primary

Site 0155

Role: primary

Site 0160

Role: primary

Site 0220

Role: primary

Site 0110

Role: primary

Site 0246

Role: primary

Site 0263

Role: primary

Site 0247

Role: primary

Site 0269

Role: primary

Site 0105

Role: primary

Site 0041

Role: primary

Site 0266

Role: primary

Site 0273

Role: primary

Site 0185

Role: primary

Site 0074

Role: primary

Site 0271

Role: primary

Site 0260

Role: primary

Site 0046

Role: primary

Site 0048

Role: primary

Site 0047

Role: primary

Site 0288

Role: primary

Site 0049

Role: primary

Site 0140

Role: primary

Site 0010

Role: primary

Site 0007

Role: primary

Site 0045

Role: primary

Site 0286

Role: primary

Site 0136

Role: primary

Site 0134

Role: primary

Site 0135

Role: primary

Site 0205

Role: primary

Site 0187

Role: primary

Site 0056

Role: primary

Site 0061

Role: primary

Site 0218

Role: primary

Related Links

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Other Identifiers

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CN012-0044

Identifier Type: -

Identifier Source: org_study_id

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