Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
40 participants
INTERVENTIONAL
2024-08-20
2026-03-31
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
CROSSOVER
OTHER
QUADRUPLE
Study Groups
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Methionine supplementation
Methionine supplementation will be achieved using commercially available methionine supplement (content methionine 500 mg, trice daily) with a monography from Health Canada (NPN 80017685) and compared to placebo pills.
Methionine-restricted diet
Methionine-restricted diet (plant-based diet) is a feasible and palatable way to achieve 50% reduction in methionine intake. Reduction to around 800 mg/day methionine will be achieved using participants' selection from low-methionine plant-based and ready to eat meals for 100% of their meals, for 6 weeks. Participants will be provided with education and a list of low methionine content food (green) and high methionine (red) for eating out, snacks and homemade meals.
Placebo
Consumption of placebo pill trice daily for 2 weeks
Methionine-restricted diet
Methionine-restricted diet (plant-based diet) is a feasible and palatable way to achieve 50% reduction in methionine intake. Reduction to around 800 mg/day methionine will be achieved using participants' selection from low-methionine plant-based and ready to eat meals for 100% of their meals, for 6 weeks. Participants will be provided with education and a list of low methionine content food (green) and high methionine (red) for eating out, snacks and homemade meals.
Interventions
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Methionine-restricted diet
Methionine-restricted diet (plant-based diet) is a feasible and palatable way to achieve 50% reduction in methionine intake. Reduction to around 800 mg/day methionine will be achieved using participants' selection from low-methionine plant-based and ready to eat meals for 100% of their meals, for 6 weeks. Participants will be provided with education and a list of low methionine content food (green) and high methionine (red) for eating out, snacks and homemade meals.
Eligibility Criteria
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Inclusion Criteria
* 20-50 years old
* On omnivorous/western diet
* Understanding French or English
Exclusion Criteria
* Glomerular filtration rate \<75 ml/h
* Liver dysfunction
* Pregnant or lactating
* Active inflammatory or infectious disease
* Insulino-dependent diabetes
* Active cancer
* Eating disorder
* BMI \< 18.5 kg/m2
* Severe food allergies or intestinal problems or active substance dependence that would prevent adherence to the experimental diet
20 Years
50 Years
ALL
Yes
Sponsors
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Multiple Sclerosis Society of Canada
OTHER
Centre hospitalier de l'Université de Montréal (CHUM)
OTHER
Responsible Party
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Locations
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Centre de recherche du Centre Hospitalier de l'Université de Montréal
Montreal, Quebec, Canada
Countries
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Central Contacts
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Facility Contacts
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Catherine Larochelle, MD, PhD
Role: primary
Other Identifiers
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23.111
Identifier Type: -
Identifier Source: org_study_id