A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes

NCT ID: NCT07282600

Last Updated: 2025-12-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE3

Total Enrollment

1035 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-12-15

Study Completion Date

2028-02-29

Brief Summary

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The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with placebo for body weight reduction in participants with overweight or obesity and type 2 diabetes. Participation in the study will last about 75 weeks.

Detailed Description

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Conditions

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Overweight Obesity

Keywords

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Type 2 Diabetes

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Eloralintide Dose 1

Participants will receive eloralintide subcutaneously (SC)

Group Type EXPERIMENTAL

Eloralintide

Intervention Type DRUG

Administered SC

Eloralintide Dose 2

Participants will receive eloralintide SC

Group Type EXPERIMENTAL

Eloralintide

Intervention Type DRUG

Administered SC

Eloralintide Dose 3

Participants will receive eloralintide SC

Group Type EXPERIMENTAL

Eloralintide

Intervention Type DRUG

Administered SC

Eloralintide Dose 4

Participants will receive eloralintide SC

Group Type EXPERIMENTAL

Eloralintide

Intervention Type DRUG

Administered SC

Placebo

Participants will receive placebo SC

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Administered SC

Interventions

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Eloralintide

Administered SC

Intervention Type DRUG

Placebo

Administered SC

Intervention Type DRUG

Other Intervention Names

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LY3841136

Eligibility Criteria

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Inclusion Criteria

* Have type 2 diabetes
* Are on stable treatment for type 2 diabetes for at least 90 days prior to screening
* Have a BMI ≥ 27 kg/m2
* Have a stable body weight (\<5% body weight change) for 90 days prior to screening

Exclusion Criteria

* Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed \>1 year before screening)
* Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
* Have type 1 diabetes
* Have taken any of the following antihyperglycemic medications within 90 days before screening:

* amylin analogs
* glucagon-like peptide-1 (GLP-1) receptor agonists
* glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 (GIP/GLP) receptor agonists, or
* insulin
* Have had within 90 days prior to screening:

* heart attack
* stroke
* coronary artery revascularization
* unstable angina, or
* hospitalization due to congestive heart failure
* Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure
* Have taken medications or alternative remedies intended for weight loss within 90 days of screening
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Eli Lilly and Company

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST)

Role: STUDY_DIRECTOR

Eli Lilly and Company

Locations

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Birmingham Clinical Research

Birmingham, Alabama, United States

Site Status NOT_YET_RECRUITING

Cullman Clinical Trials

Cullman, Alabama, United States

Site Status NOT_YET_RECRUITING

Tucson Clinical Research Institute

Tucson, Arizona, United States

Site Status SUSPENDED

San Fernando Valley Health Institute

Canoga Park, California, United States

Site Status NOT_YET_RECRUITING

AMCR Institute

Escondido, California, United States

Site Status NOT_YET_RECRUITING

NorCal Medical Research, Inc

Greenbrae, California, United States

Site Status NOT_YET_RECRUITING

Inglewood Clinical

Inglewood, California, United States

Site Status NOT_YET_RECRUITING

Ark Clinical Research

Long Beach, California, United States

Site Status RECRUITING

Pacific Clinical Studies

Los Alamitos, California, United States

Site Status NOT_YET_RECRUITING

Care Access - Santa Clarita

Santa Clarita, California, United States

Site Status NOT_YET_RECRUITING

Encompass Clinical Research

Spring Valley, California, United States

Site Status NOT_YET_RECRUITING

Diablo Clinical Research, Inc.

Walnut Creek, California, United States

Site Status NOT_YET_RECRUITING

Care Access - Aurora

Aurora, Colorado, United States

Site Status NOT_YET_RECRUITING

New England Research Associates, LLC

Bridgeport, Connecticut, United States

Site Status NOT_YET_RECRUITING

CMR of Greater New Haven, LLC

Hamden, Connecticut, United States

Site Status NOT_YET_RECRUITING

Arrow Clinical Trials

Daytona Beach, Florida, United States

Site Status NOT_YET_RECRUITING

Care Access - Delray Beach

Delray Beach, Florida, United States

Site Status NOT_YET_RECRUITING

Fleming Island Center for Clinical Research

Fleming Island, Florida, United States

Site Status NOT_YET_RECRUITING

Nature Coast Clinical Research - Inverness

Inverness, Florida, United States

Site Status NOT_YET_RECRUITING

Jacksonville Center for Clinical Research

Jacksonville, Florida, United States

Site Status NOT_YET_RECRUITING

Flourish Research Acquisition, LLC dba Flourish Research - North Miami

Miami, Florida, United States

Site Status NOT_YET_RECRUITING

New Horizon Research Center

Miami, Florida, United States

Site Status RECRUITING

Adult Medicine of Lake County, Inc.

Mt. Dora, Florida, United States

Site Status RECRUITING

American Research Centers of Florida

Pembroke Pines, Florida, United States

Site Status RECRUITING

Clinical Site Partners, LLC dba Flourish Research

Winter Park, Florida, United States

Site Status NOT_YET_RECRUITING

Teak Research Consults - Dunwoody

Dunwoody, Georgia, United States

Site Status NOT_YET_RECRUITING

Teak Research Consults

Lawrenceville, Georgia, United States

Site Status NOT_YET_RECRUITING

The Jones Center Clinical Research

Macon, Georgia, United States

Site Status NOT_YET_RECRUITING

Pacific Diabetes & Endocrine Center

Honolulu, Hawaii, United States

Site Status NOT_YET_RECRUITING

NorthShore University Health System

Skokie, Illinois, United States

Site Status NOT_YET_RECRUITING

DM Clinical Research - Indianapolis

Indianapolis, Indiana, United States

Site Status NOT_YET_RECRUITING

Clinical Trials Management, LLC d/b/a Flourish Research

Metairie, Louisiana, United States

Site Status NOT_YET_RECRUITING

IMA Clinical Research Monroe - Armand

Monroe, Louisiana, United States

Site Status NOT_YET_RECRUITING

Centennial Medical Group

Columbia, Maryland, United States

Site Status NOT_YET_RECRUITING

Lucida Clinical Trials

New Bedford, Massachusetts, United States

Site Status NOT_YET_RECRUITING

Clinical Research Professionals

Chesterfield, Missouri, United States

Site Status NOT_YET_RECRUITING

Clinvest Headlands Llc

Springfield, Missouri, United States

Site Status NOT_YET_RECRUITING

Hypertension & Nephrology Association

Eatontown, New Jersey, United States

Site Status NOT_YET_RECRUITING

IMA Clinical Research Warren

Warren Township, New Jersey, United States

Site Status NOT_YET_RECRUITING

Albuquerque Clinical Trials, Inc.

Albuquerque, New Mexico, United States

Site Status NOT_YET_RECRUITING

NYC Research INC

Long Island City, New York, United States

Site Status NOT_YET_RECRUITING

PharmQuest Life Sciences, LLC

Greensboro, North Carolina, United States

Site Status NOT_YET_RECRUITING

West Clinical Research

Morehead City, North Carolina, United States

Site Status NOT_YET_RECRUITING

Trial Management Associates - Wilmington - Floral Parkway

Wilmington, North Carolina, United States

Site Status RECRUITING

Lillestol Research

Fargo, North Dakota, United States

Site Status NOT_YET_RECRUITING

Care Access - Lima

Lima, Ohio, United States

Site Status NOT_YET_RECRUITING

Summit Headlands

Portland, Oregon, United States

Site Status NOT_YET_RECRUITING

Preferred Primary Care Physicians, Preferred Clinical Research-St. Clair

Pittsburgh, Pennsylvania, United States

Site Status NOT_YET_RECRUITING

Preferred Primary Care Physicians

Uniontown, Pennsylvania, United States

Site Status NOT_YET_RECRUITING

Accellacare - Mt Pleasant

Mt. Pleasant, South Carolina, United States

Site Status NOT_YET_RECRUITING

IMA Clinical Research Austin

Austin, Texas, United States

Site Status NOT_YET_RECRUITING

Private Practice - Dr. Osvaldo A. Brusco

Corpus Christi, Texas, United States

Site Status NOT_YET_RECRUITING

Velocity Clinical Research, Dallas

Dallas, Texas, United States

Site Status NOT_YET_RECRUITING

Diabetes and Thyroid Center of Ft. Worth

Fort Worth, Texas, United States

Site Status NOT_YET_RECRUITING

Juno Research

Houston, Texas, United States

Site Status NOT_YET_RECRUITING

Southern Endocrinology Associates

Mesquite, Texas, United States

Site Status NOT_YET_RECRUITING

Research Your Health

Plano, Texas, United States

Site Status NOT_YET_RECRUITING

IMA Clinical Research San Antonio

San Antonio, Texas, United States

Site Status NOT_YET_RECRUITING

Ogden Clinic - Canyon View

Ogden, Utah, United States

Site Status NOT_YET_RECRUITING

Diabetes & Endocrine Treatment Specialists

Sandy City, Utah, United States

Site Status NOT_YET_RECRUITING

Stat Research S.A.

Buenos Aires, , Argentina

Site Status NOT_YET_RECRUITING

Investigaciones Medicas Imoba Srl

Buenos Aires, , Argentina

Site Status NOT_YET_RECRUITING

Centro de Investigaciones Metabólicas (CINME)

Buenos Aires, , Argentina

Site Status NOT_YET_RECRUITING

Mautalen Salud e Investigación

Buenos Aires, , Argentina

Site Status NOT_YET_RECRUITING

Asociación de Beneficencia Hospital Sirio Libanés

Buenos Aires, , Argentina

Site Status NOT_YET_RECRUITING

Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada

Buenos Aires, , Argentina

Site Status NOT_YET_RECRUITING

Instituto Centenario

CABA, , Argentina

Site Status NOT_YET_RECRUITING

Centro Diabetológico Dr. Waitman

Córdoba, , Argentina

Site Status NOT_YET_RECRUITING

Centro de Investigaciones Clínicas Baigorria

Granadero Baigorria, , Argentina

Site Status NOT_YET_RECRUITING

Fundacion Estudios Clinicos

Rosario, , Argentina

Site Status NOT_YET_RECRUITING

Instituto Médico Catamarca IMEC

Rosario, , Argentina

Site Status NOT_YET_RECRUITING

Luhe Hospital

Beijing, , China

Site Status NOT_YET_RECRUITING

Peking University People's Hospital

Beijing, , China

Site Status NOT_YET_RECRUITING

Beijing Pinggu District Hospital

Beijing, , China

Site Status NOT_YET_RECRUITING

Sichuan Provincial People's Hospital

Chengdu, , China

Site Status NOT_YET_RECRUITING

The Second Affiliated Hospital Chongqing Medical University

Chongqing, , China

Site Status NOT_YET_RECRUITING

Zhujiang Hospital

Guangzhou, , China

Site Status NOT_YET_RECRUITING

The Second People's Hospital of Hefei

Hefei, , China

Site Status NOT_YET_RECRUITING

The First Affiliated Hospital of Henan University of Science &Technology

Luoyang Shi, , China

Site Status NOT_YET_RECRUITING

Jiangxi Provincial People's Hospital

Nanchang, , China

Site Status NOT_YET_RECRUITING

Nanjing First Hospital

Nanjing, , China

Site Status NOT_YET_RECRUITING

Jiangsu Province Official Hospital

Nanjing, , China

Site Status NOT_YET_RECRUITING

The Second Affiliated Hospital of Nanjing Medical University

Nanjing, , China

Site Status NOT_YET_RECRUITING

Jiading District Central Hospital

Shanghai, , China

Site Status NOT_YET_RECRUITING

The Second Hospital of Tianjin Medical University

Tianjin, , China

Site Status NOT_YET_RECRUITING

Zigong First People's Hospital

Zigong, , China

Site Status NOT_YET_RECRUITING

MUDr. Tomas Edelsberger

Krnov, , Czechia

Site Status NOT_YET_RECRUITING

MUDr. Miroslav Koliba s.r.o.

Ostrava, , Czechia

Site Status NOT_YET_RECRUITING

MUDr. Jana Parkanyiova

Prague, , Czechia

Site Status NOT_YET_RECRUITING

Diabet2 s.r.o., diabetologicka a interni ambulance

Prague, , Czechia

Site Status NOT_YET_RECRUITING

Diabetespraxis Dr. Braun

Berlin, , Germany

Site Status NOT_YET_RECRUITING

Private Practice - Dr. Kai Könemann & Dr. Henrik Könemann

Bünde, , Germany

Site Status NOT_YET_RECRUITING

InnoDiab Forschung Gmbh

Essen, , Germany

Site Status NOT_YET_RECRUITING

Diabetes Zentrum Wilhelmsburg

Hamburg, , Germany

Site Status NOT_YET_RECRUITING

Institut für Diabetesforschung GmbH Münster

Münster, , Germany

Site Status NOT_YET_RECRUITING

Schwerpunktpraxis für Diabetes und Ernährungsmedizin Dr. med. Winfried Keuthage

Münster, , Germany

Site Status NOT_YET_RECRUITING

RED-Institut GmbH

Oldenburg, , Germany

Site Status NOT_YET_RECRUITING

Life Care Hospital and Research Centre

Bangalore, , India

Site Status NOT_YET_RECRUITING

Belagavi Institute of Medical Sciences - Belagavi

Belgavi, , India

Site Status NOT_YET_RECRUITING

Dr. Ram Manohar Lohia Institute of Medical Sciences

Lucknow, , India

Site Status NOT_YET_RECRUITING

All India Institute of Medical Sciences (AIIMS) - Nagpur

Nagpur, , India

Site Status NOT_YET_RECRUITING

Lifepoint Multispeciality Hospital

Pune, , India

Site Status NOT_YET_RECRUITING

Ashirwad Hospital and Research Centre

Ulhasnagar, , India

Site Status NOT_YET_RECRUITING

Hayashi Diabetes Internal Medicine Clinic

Chigasaki, , Japan

Site Status NOT_YET_RECRUITING

Tokyo-Eki Center-building Clinic

Chūōku, , Japan

Site Status NOT_YET_RECRUITING

Shonan Takai Clinic

Kamakura, , Japan

Site Status NOT_YET_RECRUITING

Oishi Clinic

Kasuya-gun, , Japan

Site Status NOT_YET_RECRUITING

OHAMA Diabetes Clinic

Kawaguchi, , Japan

Site Status NOT_YET_RECRUITING

Higashijujo Sakai Diabetes Internal Medicine Clinic

Kita-ku, , Japan

Site Status NOT_YET_RECRUITING

Tokuyama Clinic

Mihama-ku,Chiba City, , Japan

Site Status NOT_YET_RECRUITING

Shinkenko clinic

Naha, , Japan

Site Status NOT_YET_RECRUITING

Oyama East Clinic

Oyama, , Japan

Site Status NOT_YET_RECRUITING

Shimokitazawa Tomo Clinic

Setagaya-ku, , Japan

Site Status NOT_YET_RECRUITING

Soka Sugiura Internal Medicine Clinic

Sōka, , Japan

Site Status NOT_YET_RECRUITING

Tsuchiura Medical & Health Care Center

Tsuchiura, , Japan

Site Status NOT_YET_RECRUITING

Tsuchiura Beryl Clinic

Tsuchiura, , Japan

Site Status NOT_YET_RECRUITING

Noritake Clinic

Ushiku, , Japan

Site Status NOT_YET_RECRUITING

Yokohama Minoru Clinic

Yokohama, , Japan

Site Status NOT_YET_RECRUITING

Instituto Jalisciense de Investigacion en Diabetes y Obesidad

Guadalajara, , Mexico

Site Status NOT_YET_RECRUITING

Centro de Investigacion Medica de Occidente, S.C.

Guadalajara, , Mexico

Site Status NOT_YET_RECRUITING

Unidad de Investigación Clínica y Atención Médica HEPA S.C.

Guadalajara, , Mexico

Site Status NOT_YET_RECRUITING

Medical Care and Research SA de CV

Mérida, , Mexico

Site Status NOT_YET_RECRUITING

Cardiolink Clin Trials

Monterrey, , Mexico

Site Status NOT_YET_RECRUITING

Niepubliczny Specjalistyczny Zaklad Opieki Zdrowotnej Osrodek Diabetologiczny Popula Spolka Cywilna

Bialystok, , Poland

Site Status NOT_YET_RECRUITING

Centrum Medyczne NEUROMED

Bydgoszcz, , Poland

Site Status NOT_YET_RECRUITING

Ambulatorium Sp. z o.o.

Elblag, , Poland

Site Status NOT_YET_RECRUITING

Medyczne Centrum Diabetologiczno Endokrynologiczno Metaboliczne DIAB-ENDO-MET

Krakow, , Poland

Site Status NOT_YET_RECRUITING

Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna

Lodz, , Poland

Site Status NOT_YET_RECRUITING

Ekamed

Lublin, , Poland

Site Status NOT_YET_RECRUITING

NZOZ Przychodnia Specjalistyczna Andrzej Wittek, Henryk Rudzki

Ruda Śląska, , Poland

Site Status NOT_YET_RECRUITING

Samodzielny Publiczny Szpital Kliniczny nr 1 SUM

Zabrze, , Poland

Site Status NOT_YET_RECRUITING

Centro de Endocrinologia y Nutricion

Caguas, , Puerto Rico

Site Status NOT_YET_RECRUITING

Dorado Medical Complex

Dorado, , Puerto Rico

Site Status NOT_YET_RECRUITING

Diacrin s.r.o.

Bratislava, , Slovakia

Site Status NOT_YET_RECRUITING

MediVet s.r.o.

Malacky, , Slovakia

Site Status NOT_YET_RECRUITING

B-Medical, s.r.o.

Námestovo, , Slovakia

Site Status NOT_YET_RECRUITING

FUNKYSTUFF s.r.o.

Nové Zámky, , Slovakia

Site Status NOT_YET_RECRUITING

DIA-MED CENTRUM s.r.o.

Púchov, , Slovakia

Site Status NOT_YET_RECRUITING

MEDI-DIA s.r.o.

Sabinov, , Slovakia

Site Status NOT_YET_RECRUITING

Korea University Ansan Hospital

Ansan-si, , South Korea

Site Status NOT_YET_RECRUITING

The Catholic University of Korea, Bucheon St. Mary's Hospital

Bucheon-si, , South Korea

Site Status NOT_YET_RECRUITING

Hanyang University Guri Hospital

Guri-si, , South Korea

Site Status NOT_YET_RECRUITING

Chosun University Hospital

Gwangju, , South Korea

Site Status NOT_YET_RECRUITING

Seoul National University Bundang Hospital

Seongnam, , South Korea

Site Status NOT_YET_RECRUITING

Severance Hospital, Yonsei University Health System

Seoul, , South Korea

Site Status NOT_YET_RECRUITING

Hospital Universitario de La Ribera

Alzira, , Spain

Site Status NOT_YET_RECRUITING

Hospital Universitari Vall d'Hebron

Barcelona, , Spain

Site Status NOT_YET_RECRUITING

Hospital Clínic de Barcelona

Barcelona, , Spain

Site Status NOT_YET_RECRUITING

Complejo Hospitalario Ruber Juan Bravo

Madrid, , Spain

Site Status NOT_YET_RECRUITING

H.R.U Málaga - Hospital Civil

Málaga, , Spain

Site Status NOT_YET_RECRUITING

Hospital Universitario Virgen de la Victoria

Málaga, , Spain

Site Status NOT_YET_RECRUITING

Centro Médico Compostela

Santiago de Compostela, , Spain

Site Status NOT_YET_RECRUITING

Hospital Universitario Virgen Del Rocio

Seville, , Spain

Site Status NOT_YET_RECRUITING

Vithas Hospital Sevilla

Seville, , Spain

Site Status NOT_YET_RECRUITING

Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung City, , Taiwan

Site Status NOT_YET_RECRUITING

Chang Gung Memorial Hospital at Kaohsiung

Kaohsiung Niao Sung Dist, , Taiwan

Site Status NOT_YET_RECRUITING

National Taiwan University Hospital

Taipei, , Taiwan

Site Status NOT_YET_RECRUITING

Taipei Veterans General Hospital

Taipei, , Taiwan

Site Status NOT_YET_RECRUITING

Chang Gung Medical Foundation-Linkou Branch

Taoyuan District, , Taiwan

Site Status NOT_YET_RECRUITING

Countries

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United States Argentina China Czechia Germany India Japan Mexico Poland Puerto Rico Slovakia South Korea Spain Taiwan

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or

Role: CONTACT

Phone: 317-615-4559

Email: [email protected]

Physicians interested in becoming principal investigators please contact

Role: CONTACT

Email: [email protected]

Facility Contacts

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Related Links

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https://trials.lilly.com/en-US/trial/673735

A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes (ENLIGHTEN-2)

Other Identifiers

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J3R-MC-YDAF

Identifier Type: OTHER

Identifier Source: secondary_id

2025-523658-15-00

Identifier Type: CTIS

Identifier Source: secondary_id

27741

Identifier Type: -

Identifier Source: org_study_id