ZYNRELEF vs Continuous Catheter for Pain Management Following Shoulder Arthroplasty
NCT ID: NCT07280195
Last Updated: 2025-12-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
PHASE4
86 participants
INTERVENTIONAL
2025-12-31
2027-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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ZYNRELEF
Zynrelef
ZYNRELEF
Interscalene block with continuous catheter pump
Bupivacaine
Interscalene block with continuous catheter pump
Interventions
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Zynrelef
ZYNRELEF
Bupivacaine
Interscalene block with continuous catheter pump
Eligibility Criteria
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Inclusion Criteria
2. Indicated to undergo primary total shoulder arthroplasty (anatomic or reverse)
Exclusion Criteria
2. Patients undergoing revision arthroplasty or reverse shoulder arthroplasty
3. Proximal humerus fractures
4. Inability to have interscalene anesthetic catheter placement
5. Compromised baseline renal function (CrCl \< 50)
6. BMI \> 40
7. History of GI bleed, prior duodenal surgery, or gastric sleeve resection
8. Current narcotic use or prior consistent narcotic exposure in the last 6 months
9. Use of perioperative oral steroid medications
10. Active Workman's compensation claim
11. Prior shoulder arthroplasty on the contralateral side in which an interscalene catheter was used
18 Years
ALL
No
Sponsors
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Washington University School of Medicine
OTHER
Responsible Party
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Alexander Aleem
Associate Professor
Principal Investigators
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Alexander Aleem, MD
Role: PRINCIPAL_INVESTIGATOR
Washington University School of Medicine
Locations
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Washington University
St Louis, Missouri, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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202509174
Identifier Type: -
Identifier Source: org_study_id
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