Neural Mechanisms of Fatigue in Post-Acute Sequela of SARS-CoV-2
NCT ID: NCT07278388
Last Updated: 2025-12-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
200 participants
INTERVENTIONAL
2025-07-16
2029-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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PASC Participants - Physical Fatigue Task
Participants will perform a physically demanding task (grip force exertion task) repeatedly to induce physical fatigue.
Physical Fatigue
Participants will perform a physically demanding task (grip force exertion task) repeatedly to induce physical fatigue.
Control Participants - Physical Fatigue Task
Participants will perform a physically demanding task (grip force exertion task) repeatedly to induce physical fatigue.
Physical Fatigue
Participants will perform a physically demanding task (grip force exertion task) repeatedly to induce physical fatigue.
Interventions
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Physical Fatigue
Participants will perform a physically demanding task (grip force exertion task) repeatedly to induce physical fatigue.
Eligibility Criteria
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Inclusion Criteria
* Have received a clinical diagnosis of post-acute sequelae of SARS-CoV-2 (PASC)/long COVID syndrome using the criteria specified by Thaweethai, et al., 2023 (JAMA). This symptom checklist provides a score based on the number and severity of symptoms. An individual with a score \>12 is classified as having PASC.
* Currently experiencing Fatigue/Brain Fog as assessed with the Post-COVID symptom checklist and the PedsQL questionnaire.
Exclusion Criteria
* Diagnosed history of severe psychiatric diseases such as depression and schizophrenia (self-report).
* Congestive heart failure.
* Peripheral artery disease with claudication.
* Cancer.
* Pulmonary or renal failure.
* Unstable angina.
* Uncontrolled hypertension (more than 190/110 mmHg).
* Severe aphasia.
* Orthopedic or pain conditions.
* Have had exposure to metal or metal implants, due to the hazardous effects of the magnetic field.
* If on immunomodulatory therapy, they must have been on that therapy for at least 6 months before the start of the study.
* Hospitalization due to SARS-CoV-2 infection.
* Neurological disorders including, but not limited to, stroke, head injury, epilepsy, seizures, brain tumors, brain surgery, Parkinson's Disease, or any other neuromuscular disease (self-report).
* Diagnosed history of severe psychiatric diseases such as depression and schizophrenia (self-report).
* Congestive heart failure.
* Peripheral artery disease with claudication.
18 Years
75 Years
ALL
Yes
Sponsors
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National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
OTHER
Responsible Party
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Principal Investigators
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Vikram Chib, PhD
Role: PRINCIPAL_INVESTIGATOR
Johns Hopkins University; Kennedy Krieger Institute
Locations
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Kennedy Krieger Institute
Baltimore, Maryland, United States
Countries
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Central Contacts
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Vikram Chib, PhD
Role: CONTACT
Facility Contacts
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Other Identifiers
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IRB00283000_1
Identifier Type: -
Identifier Source: org_study_id
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