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Effects of Platelet and Leukocyte-rich Fibrin on Alveolar Ridge Maintenance Through Three-dimensional Analysis

NCT ID: NCT07278180

Last Updated: 2025-12-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-01-20

Study Completion Date

2022-01-20

Brief Summary

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Understanding, through accurate and reliable volumetric analysis, how the biomaterial (LPRF) and the thickness of the vestibular bone plate influence changes in bone volume after extraction, is essential for making clinical decisions that impact implant-supported rehabilitation.

Detailed Description

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Conditions

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Caries Active Tooth Decay Tooth Loss / Rehabilitation

Keywords

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tooth loss decay caries biomaterials

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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platelet rich firbrin

Alveolar socket preservation with graft and flap surgery

Intervention Type PROCEDURE

teeth to either the control group (coagulant-filled alveoli) or the test group (alveoli filled with platelet-rich fibrin and LPRF leukocytes)

Interventions

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Alveolar socket preservation with graft and flap surgery

teeth to either the control group (coagulant-filled alveoli) or the test group (alveoli filled with platelet-rich fibrin and LPRF leukocytes)

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

This prospective clinical study was conducted in accordance with the ethical principles outlined in the Declaration of Helsinki and received approval from the Research Ethics Committee of Guarulhos University, São Paulo, Brazil (CEP-UnG #. 515.153). Thirty-nine patients (24 women and 15 men), aged between 22 and 80 years, who were in overall good health, non-diabetic, periodontally healthy, non-smokers, free of blood dyscrasias, not pregnant or lactating, and requiring extraction of non-contiguous, compromised teeth due to root fractures, caries, unsuccessful endodontic treatment, root resorption, or orthodontic reasons, were enrolled.
Minimum Eligible Age

21 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Guarulhos

OTHER

Sponsor Role lead

Responsible Party

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Jamil awad shibli

Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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UnG 17917313.7.0000.5506

Identifier Type: -

Identifier Source: org_study_id