Comparative Effects of Sensory Augmentation and Neuromodulation on Enhancing Motor Recovery Among Stroke Survivors
NCT ID: NCT07266662
Last Updated: 2025-12-17
Study Results
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Basic Information
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RECRUITING
NA
36 participants
INTERVENTIONAL
2025-11-25
2026-05-30
Brief Summary
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Detailed Description
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This study will focus on evaluating the comparative effects of two innovative rehabilitation approaches-Sensory Augmentation through Mirror Therapy and Neuromodulation through Transcranial Direct Current Stimulation (tDCS)-on motor recovery in chronic stroke survivors. These two techniques have shown promising results in improving motor function in stroke patients, but their combined effect remains unclear.
Intervention Strategies:
Sensory Augmentation: Mirror therapy is a non-invasive technique that involves using a mirror to create the illusion of movement in the affected limb by reflecting the movement of the unaffected limb. This process enhances the sensory feedback and promotes neuroplasticity, which is the brain's ability to reorganize and form new neural connections. Mirror therapy has been shown to reduce spasticity, improve sensory functions like proprioception, and facilitate the restoration of motor function.
Neuromodulation: Transcranial Direct Current Stimulation (tDCS) is a non-invasive brain stimulation technique that uses a low electrical current to modulate neuronal activity in specific areas of the brain. For stroke survivors, tDCS is applied to the motor cortex to promote neuroplasticity, facilitate the relearning of motor tasks, and reduce spasticity. While previous studies have demonstrated the effectiveness of tDCS, its impact when combined with sensory augmentation has not been fully explored.
Study Design and Groups:
This randomized controlled trial will involve 36 chronic stroke patients aged 45-65 who have upper extremity motor impairments. The participants will be randomly assigned to one of three groups:
Group 1 (Experimental Group): A combination of sensory augmentation (mirror therapy) and neuromodulation (tDCS) along with routine physical therapy.
Group 2: Sensory augmentation (mirror therapy) combined with routine physical therapy.
Group 3: Neuromodulation (tDCS) combined with routine physical therapy.
Each participant will undergo the interventions four times a week for 8 weeks. Routine physical therapy will include task-oriented training and reflex inhibitory patterns exercises aimed at improving motor control and coordination. Both sensory augmentation and neuromodulation will be administered for 30 minutes per session, with each intervention lasting 15 minutes for mirror therapy and 15 minutes for tDCS. The entire session, including physical therapy, will last for 45 minutes.
Outcome Measures:
The primary outcome of the study will be the improvement in upper limb motor function, measured by the Fugl-Meyer Assessment (FMA) for motor function and the Jebsen-Taylor Test, which assesses functional hand tasks. These assessments will be conducted before the intervention, at 4 weeks, and at 8 weeks to evaluate both short-term and long-term effects.
Secondary outcomes will include improvements in the quality of life, as measured by validated scales like the Stroke Impact Scale (SIS), and the impact on daily activities, such as handgrip strength, motor coordination, and task performance. The effects on spasticity and sensory function will also be monitored.
Data Collection and Analysis:
Data will be collected at multiple time points during the study to assess the effects of the interventions on motor function, spasticity, and quality of life. Statistical analyses will include mixed-model ANOVA to examine the effects of time and intervention group on the primary and secondary outcomes. Post-intervention comparisons will be made to assess the differential impact of each intervention. Additionally, repeated measures ANOVA will be conducted to track within-group improvements over time.
Safety and Ethics:
This study has been approved by the institutional review board (IRB) of Lahore University of Biological and Applied Sciences, and all participants will provide informed consent before participating. To ensure the safety of participants, all sessions will be conducted under the supervision of trained physical therapists. Minimal risks associated with the study include mild discomfort or fatigue during the physical assessments and interventions. If any participant experiences adverse effects, they will be promptly withdrawn from the study.
The study will also ensure the confidentiality of all participant data. Personal information will be anonymized, and data will be stored securely. Participation in the study is voluntary, and participants may withdraw at any time without facing any negative consequences.
Significance and Potential Impact:
This study has the potential to significantly impact stroke rehabilitation practices by providing evidence on the comparative efficacy of sensory augmentation and neuromodulation techniques in enhancing motor recovery. The results may guide clinicians in developing more effective rehabilitation protocols and inform future research on combined rehabilitation strategies.
Given the growing incidence of stroke worldwide, particularly in low- and middle-income countries, this research could pave the way for accessible, cost-effective, and non-invasive therapeutic interventions. It may offer stroke survivors, especially those in resource-limited settings, improved chances for motor recovery and a better quality of life. Furthermore, this study will contribute valuable data to the scientific community, offering insights into the combined effects of mirror therapy and tDCS, which could enhance the evidence base for stroke rehabilitation.
Conclusion:
By comparing the effects of sensory augmentation and neuromodulation, this study aims to identify the most effective intervention(s) for improving motor recovery in stroke survivors. The findings will not only contribute to the field of neurorehabilitation but may also offer new therapeutic options for patients in need of effective, evidence-based treatments for motor impairments post-stroke.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Group 1 (combination of Multisensory Augmentation and Neuromodulation with Routine Physical Therapy)
Group 1 will receive a combination of Multisensory Augmentation (Mirror Therapy) and Neuromodulation (Transcranial Direct Current Stimulation - tDCS) along with Routine Physical Therapy. The interventions will be administered four times a week over an 8-week period. The multisensory augmentation component will involve Mirror Therapy, where participants will perform motor tasks with their unaffected arm while observing its reflection in a mirror placed in front of them, simulating movement of the affected arm. This therapy enhances sensory feedback and promotes neuroplasticity.
The neuromodulation component will involve tDCS, where a low electrical current will be applied to the motor cortex to modulate cortical excitability and promote neuroplastic changes, supporting motor relearning and reducing spasticity. Each session will consist of 15 minutes of Mirror Therapy and 15 minutes of tDCS stimulation, followed by Routine Physical Therapy, which includes task-oriented training and refl
Combination of Sensory Augmentation and Neuromodulation
The combined intervention will integrate Transcranial Direct Current Stimulation (tDCS) and Mirror Therapy to enhance motor recovery through both brain stimulation and sensory feedback. tDCS will apply a low electrical current to the motor cortex to modulate brain activity, promoting neuroplasticity, reducing spasticity, and facilitating motor relearning. Mirror Therapy will provide visual feedback by having participants perform tasks with their unaffected arm while observing its reflection in a mirror, simulating movement in the affected arm and stimulating sensory-motor pathways. This combined approach aims to maximize neuroplasticity by targeting both the brain and sensory processing systems. Each session will last 45 minutes: 15 minutes of Mirror Therapy, 15 minutes of tDCS, and 15 minutes of Routine Physical Therapy, conducted four times a week for 8 weeks.
Group 2 (only sensory augmentation and Routine Physical Therapy)
Group 2 will receive Sensory Augmentation (Mirror Therapy) in combination with Routine Physical Therapy. The interventions will be administered four times a week over an 8-week period. Mirror Therapy will involve participants performing motor tasks with their unaffected arm while observing its reflection in a mirror placed in front of them, creating the illusion of movement in the affected arm. This technique enhances sensory feedback and promotes neuroplasticity, which is critical for motor recovery in stroke survivors.
In addition to Mirror Therapy, participants will also undergo Routine Physical Therapy for 20 minutes per session. The physical therapy will include task-oriented training and reflex inhibitory exercises designed to improve motor control, strength, and coordination. Each session will last 45 minutes, with 25 minutes dedicated to the sensory augmentation intervention and physical therapy combined. This arm aims to assess the effects of sensory augmentation alone on mot
Sensory Augmentation
Sensory Augmentation in this study will use Mirror Therapy, a non-invasive technique aimed at enhancing sensory feedback and promoting neuroplasticity. Participants will perform tasks with their unaffected arm while observing its reflection in a mirror placed in front of them, creating the illusion that the affected arm is moving. This visual feedback stimulates sensory pathways and encourages the brain to reorganize motor functions. Each session will last 15 minutes, conducted four times a week for 8 weeks, alongside Routine Physical Therapy. Mirror therapy differs from other rehabilitation methods by focusing on sensory-motor deficits through visual feedback, encouraging neuroplasticity and motor recovery, especially in chronic stroke patients with upper limb impairments.
Group 3 (neuromodulation only and Routine Physical Therapy)
Group 3 will receive Neuromodulation (Transcranial Direct Current Stimulation - tDCS) in combination with Routine Physical Therapy. The interventions will be administered four times a week over an 8-week period. tDCS involves the application of a low electrical current to the motor cortex, modulating cortical excitability to promote neuroplasticity and support motor relearning while reducing spasticity. The tDCS session will last 20 minutes, with a 5-minute break during the session.
In addition to tDCS, participants will also undergo Routine Physical Therapy for 20 minutes per session. The physical therapy will include task-oriented training and reflex inhibitory exercises designed to enhance motor control, strength, and functional movement. Each session will last 45 minutes, with 20 minutes dedicated to tDCS and 20 minutes to physical therapy. This arm will evaluate the impact of neuromodulation alone on motor recovery when combined with traditional physical rehabilitation techniques
Neuromodulation
Neuromodulation in this study will use Transcranial Direct Current Stimulation (tDCS), a non-invasive technique to modulate brain activity. A low electrical current will be applied to the motor cortex to enhance cortical excitability, promote neuroplasticity, and support motor relearning. tDCS helps reduce spasticity and facilitates recovery of motor functions by altering neural activity in targeted areas of the brain. Each session will last 20 minutes, with a 5-minute break, conducted four times a week for 8 weeks, alongside Routine Physical Therapy. tDCS stands apart from other therapies by directly stimulating brain regions to enhance neural plasticity, targeting motor function recovery through brain stimulation rather than external physical exercises alone.
Interventions
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Sensory Augmentation
Sensory Augmentation in this study will use Mirror Therapy, a non-invasive technique aimed at enhancing sensory feedback and promoting neuroplasticity. Participants will perform tasks with their unaffected arm while observing its reflection in a mirror placed in front of them, creating the illusion that the affected arm is moving. This visual feedback stimulates sensory pathways and encourages the brain to reorganize motor functions. Each session will last 15 minutes, conducted four times a week for 8 weeks, alongside Routine Physical Therapy. Mirror therapy differs from other rehabilitation methods by focusing on sensory-motor deficits through visual feedback, encouraging neuroplasticity and motor recovery, especially in chronic stroke patients with upper limb impairments.
Neuromodulation
Neuromodulation in this study will use Transcranial Direct Current Stimulation (tDCS), a non-invasive technique to modulate brain activity. A low electrical current will be applied to the motor cortex to enhance cortical excitability, promote neuroplasticity, and support motor relearning. tDCS helps reduce spasticity and facilitates recovery of motor functions by altering neural activity in targeted areas of the brain. Each session will last 20 minutes, with a 5-minute break, conducted four times a week for 8 weeks, alongside Routine Physical Therapy. tDCS stands apart from other therapies by directly stimulating brain regions to enhance neural plasticity, targeting motor function recovery through brain stimulation rather than external physical exercises alone.
Combination of Sensory Augmentation and Neuromodulation
The combined intervention will integrate Transcranial Direct Current Stimulation (tDCS) and Mirror Therapy to enhance motor recovery through both brain stimulation and sensory feedback. tDCS will apply a low electrical current to the motor cortex to modulate brain activity, promoting neuroplasticity, reducing spasticity, and facilitating motor relearning. Mirror Therapy will provide visual feedback by having participants perform tasks with their unaffected arm while observing its reflection in a mirror, simulating movement in the affected arm and stimulating sensory-motor pathways. This combined approach aims to maximize neuroplasticity by targeting both the brain and sensory processing systems. Each session will last 45 minutes: 15 minutes of Mirror Therapy, 15 minutes of tDCS, and 15 minutes of Routine Physical Therapy, conducted four times a week for 8 weeks.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Gender: both male and female
* Ischemic stroke
* Diagnosed cases of middle cerebral artery stroke by neurologist
* Stage of recovery - Chronic (more than 6 months)
* Burnstromm recovery stage 3
* Good Compliance
Exclusion Criteria
* Serious cognitive impairment,
* Severe vision or visuospatial neglect
* Spasticity (Modified Ashworth scale \>3)
* Upper extremity contractures
* Upper extremity fractures
* Orthopedic disease
* Neurological conditions (other than stroke)
* Recurrence of stroke or epilepsy during the study period
* Serious systemic impairment or concomitant diseases
* Patients refused to participate in the experiment
45 Years
56 Years
ALL
No
Sponsors
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Lahore University of Biological and Applied Sciences
OTHER
Responsible Party
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Principal Investigators
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Nabeela Dawood
Role: STUDY_CHAIR
Lahore University of Biological and Applied Sciences
Locations
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Lahore University of Biological and Applied Sciences
Lahore, Punjab Province, Pakistan
Pakistan Society of Rehabilitation and Differently Abled Hospital
Lahore, Punjab Province, Pakistan
Countries
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Central Contacts
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References
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Shahid J, Kashif A, Shahid MK. A Comprehensive Review of Physical Therapy Interventions for Stroke Rehabilitation: Impairment-Based Approaches and Functional Goals. Brain Sci. 2023 Apr 25;13(5):717. doi: 10.3390/brainsci13050717.
Norman SL, Wolpaw JR, Reinkensmeyer DJ. Targeting neuroplasticity to improve motor recovery after stroke: an artificial neural network model. Brain Commun. 2022 Oct 21;4(6):fcac264. doi: 10.1093/braincomms/fcac264. eCollection 2022.
Harris JE, Eng JJ. Paretic upper-limb strength best explains arm activity in people with stroke. Phys Ther. 2007 Jan;87(1):88-97. doi: 10.2522/ptj.20060065. Epub 2006 Dec 19.
Li S. Spasticity, Motor Recovery, and Neural Plasticity after Stroke. Front Neurol. 2017 Apr 3;8:120. doi: 10.3389/fneur.2017.00120. eCollection 2017.
Coupland AP, Thapar A, Qureshi MI, Jenkins H, Davies AH. The definition of stroke. J R Soc Med. 2017 Jan;110(1):9-12. doi: 10.1177/0141076816680121. Epub 2017 Jan 13. No abstract available.
Other Identifiers
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UBAS/ERB/FoRS/25/033 Asad Ali
Identifier Type: -
Identifier Source: org_study_id