Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
20 participants
INTERVENTIONAL
2026-03-01
2026-03-30
Brief Summary
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The main questions it aims to answer is:
1. Can sufficient eligible participants be enrolled within the planned timeframe?
2. Is there any retention of participant throughout the study duration and the factors contributing to ongoing participation?
3. Can participants adhere to pre-treatment instructions and protocols before their first check-up?
4. Can participants attend and complete all assessments and chiropractic sessions?
5. Can participants fulfill all required study activities without excessive burden?
6. Can chiropractors strictly follow chiropractic adjustments only, without offering any additional treatments?
Researchers will compare adults with depression on the waitlist group to see if chiropractic care effects on adults with depression.
Participants will
* Perform resting state Electrocardiography (ECG)
* Perform resting state Electroencephalography (EEG)
* Perform Event-related potential (ERP) à Auditory and visual stimuli tests
* Complete Patient Reported Outcomes (PROs)
* COMPASS-31
* PROMIS-29
* PROMIS-Cog-8
* Perceived Stress Scale
* Depression Short Form 8a
* Complete Assessment of Acceptability
* Complete Columbia Suicide Severity Rating Scale (C-SSRS)
* Receive 6 weeks of chiropractic care treatment
Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Waitlist Group (WL)
After the 6-week lab assessments, the participants in the waitlist (WL) group will be offered 6 weeks of chiropractic care.
Chiropractic Care
Participants of the treatment group will be randomly assigned to chiropractic care for 6 weeks. Participants will have their upper cervical spine (C1/C2) assessed for the presence of vertebral subluxations per the chiropractor's normal and customary procedures.
Intervention Group
Within the 6-week lab assessments, the participants in the intervention group will receive 6 weeks of chiropractic care.
Chiropractic Care
Participants of the treatment group will be randomly assigned to chiropractic care for 6 weeks. Participants will have their upper cervical spine (C1/C2) assessed for the presence of vertebral subluxations per the chiropractor's normal and customary procedures.
Interventions
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Chiropractic Care
Participants of the treatment group will be randomly assigned to chiropractic care for 6 weeks. Participants will have their upper cervical spine (C1/C2) assessed for the presence of vertebral subluxations per the chiropractor's normal and customary procedures.
Eligibility Criteria
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Inclusion Criteria
* Mild (T-score 55-59) to moderate (T-score 60-69) depression, as measured by the PROMIS® Depression - Short Form 8a, an 8-question survey that assesses symptoms like sadness and hopelessness.
Exclusion Criteria
* Diagnosed with any untreated or uncontrolled externalizing disorders (like substance use or antisocial disorder) or thought disorders (like schizophrenia, paranoid personality, or bipolar).
* Diagnosis of rheumatoid arthritis, osteoporosis, or cervical spine instability
* Has hearing impairments (task involves auditory stimuli)
* Currently pregnant (if applicable)
* Chiropractic adjustment within the past 2 weeks
* Scalp injuries or surgeries within the past 3 months
* Prescribed short-acting benzodiazepines, which include midazolam \& triazolam
* Current litigation related to a physical, health-related injury.
* Diagnosed heart conditions, including pacemakers.
* Living with and/or caring for someone with a diagnosed neuropsychiatric disorder
18 Years
65 Years
ALL
No
Sponsors
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Life University
OTHER
Responsible Party
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Locations
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Center for Chiropractic Research
Marietta, Georgia, United States
Countries
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Central Contacts
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Facility Contacts
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Daekiara Smith-Ireland, MPH, DrPH
Role: primary
Role: backup
Other Identifiers
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I-0035
Identifier Type: -
Identifier Source: org_study_id