Using Strength Tests to Better Understand How Pancreatic Cancer Affects Muscle Mass and Quality of Life

NCT ID: NCT07255001

Last Updated: 2025-11-28

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 50 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-12-31
• Study Completion Date: 2027-12-31

Brief Summary

The goal of this clinical trial is to measure hand grip strength in adults with pancreatic ductal adenocarcinoma (PDAC). The main questions it aims to answer are:

• Is it feasible to measure hand grip strength as part of a clinic visit?
• Are changes in hand grip strength related to changes in body composition?
• Is hand grip strength related to a person's well-being?
• Is hand grip strength related to how a tumour responds to treatment?

Participants will squeeze a device with their hand to measure their hand grip strength and complete questionnaires about their well-being when they are seen in clinic for their regular medical care for PDAC.

Conditions

Pancreatic Ductal Adenocarcinoma (PDAC); Hand Grip Strength

Keywords

Pancreatic ductal adenocarcinoma (PDAC); Hand grip strength (HGS); Quality of Life (QOL); Body composition; Cachexia; Sarcopenia; Physical function; Skeletal muscle; Adipose tissue

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Main Study Arm

The study arm all participants are enrolled into. Participants will complete hand grip strength assessments and questionnaires.

Group Type: EXPERIMENTAL

Hand grip strength assessments using a dynamometer

Intervention Type: DEVICE

Squeeze a dynamometer with one hand to measure hand grip strength.

Interventions

Hand grip strength assessments using a dynamometer

Squeeze a dynamometer with one hand to measure hand grip strength.

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Age 18 years or older.
• Histological and/or radiological diagnosis of resectable, non-resectable, or metastatic PDAC. For resectable PDAC, adjuvant setting only.
• ECOG performance status 0-2.
• Life expectancy greater than 6 months as judged by the investigator.
• Planned for treatment, either as part of routine care or in combination with an investigational agent within another study.
• Ability to hold a dynamometer with one hand.

Exclusion Criteria

• Individuals with CT imaging performed outside of Vancouver, BC, Canada.
• Individuals who are unfit to undergo CT imaging of the third lumbar vertebra (L3).
• Individuals who are currently participating in a structured moderate intensity resistance training program.
• Individuals who are otherwise judged by the investigator to be unfit to proceed with this protocol.
• Unable to comply with study assessments and follow-up.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

British Columbia Cancer Agency

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

BC Cancer

Vancouver, British Columbia, Canada

Countries

Canada

Central Contacts

Daniel J Renouf, MD, MPH

Role: CONTACT

Phone: 800-663-3333

Email: drenouf@bccancer.bc.ca

Facility Contacts

Daniel J Renouf, MD, MPH

Role: primary

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Other Identifiers

H25-00754

Identifier Type: -

Identifier Source: org_study_id