Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
200 participants
INTERVENTIONAL
2025-12-18
2028-11-07
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
OTHER
NONE
Study Groups
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Aim 1: Socially Evaluated Cold Pressor Task (SECPT)
Participants will be randomly assigned to complete the Socially Evaluated Cold Pressor Task (SECPT). Cortisol samples will be collected throughout the study session. All participants will then complete a Food Value Task, during which they will view a series of reward stimuli (snack foods) over alternating task blocks.
Socially Evaluated Cold Pressor Task (SECPT)
The SECPT is a validated laboratory stressor that combines physiological stress with social evaluative components; it is widely used to elicit acute stress responses in controlled settings. Participants are asked to submerge their nondominant hand into an ice-cold water (0-4°C) for 3 minutes, while videotaped and observed by one neutral-faced experimenter.
Aim 1: Non-Stressful Control Task
Participants will be randomly assigned to complete a non-stressful control task. Cortisol samples will be collected throughout the study session. All participants will then complete a Food Value Task, during which they will view a series of reward stimuli (snack foods) over alternating task blocks.
Non-Stressful Control Task
Participants assigned to the warm water control condition will perform a non-evaluative task with warm water.
Aim 2: Socially Evaluated Cold Pressor Task (SECPT)
Participants will be randomly assigned to complete the SECPT. Cortisol samples will be collected throughout the study session. Participants will then complete the Image Value Task, during which they will view a series of positive, negative or neutral images over alternating task blocks.
Socially Evaluated Cold Pressor Task (SECPT)
The SECPT is a validated laboratory stressor that combines physiological stress with social evaluative components; it is widely used to elicit acute stress responses in controlled settings. Participants are asked to submerge their nondominant hand into an ice-cold water (0-4°C) for 3 minutes, while videotaped and observed by one neutral-faced experimenter.
Aim 2: Non-Stressful Control Task
Participants will be randomly assigned to complete a non-stressful control task. Cortisol samples will be collected throughout the study session. Participants will then complete the Image Value Task, during which they will view a series of positive, negative or neutral images over alternating task blocks.
Non-Stressful Control Task
Participants assigned to the warm water control condition will perform a non-evaluative task with warm water.
Aim 3: Socially Evaluated Cold Pressor Task (SECPT)
Participants will first complete demographic and self-report measures, followed by random assignment to complete the SECPT. Cortisol samples will be collected throughout the study session to measure neuroendocrine response to the stress/control task. Participants will then complete the Affective Prediction Error Task.
Socially Evaluated Cold Pressor Task (SECPT)
The SECPT is a validated laboratory stressor that combines physiological stress with social evaluative components; it is widely used to elicit acute stress responses in controlled settings. Participants are asked to submerge their nondominant hand into an ice-cold water (0-4°C) for 3 minutes, while videotaped and observed by one neutral-faced experimenter.
Aim 3: Non-Stressful Control Task
Participants will be randomly assigned to complete a non-stressful control task. Cortisol samples will be collected throughout the study session. Participants will then complete the Affective Prediction Task.
Non-Stressful Control Task
Participants assigned to the warm water control condition will perform a non-evaluative task with warm water.
Aim 4: Behavioral Task
Participants with a diagnosis of generalized anxiety disorder (GAD) will complete a two-session behavioral task examining how clinical anxiety affects value and affective predictions.
No interventions assigned to this group
Interventions
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Socially Evaluated Cold Pressor Task (SECPT)
The SECPT is a validated laboratory stressor that combines physiological stress with social evaluative components; it is widely used to elicit acute stress responses in controlled settings. Participants are asked to submerge their nondominant hand into an ice-cold water (0-4°C) for 3 minutes, while videotaped and observed by one neutral-faced experimenter.
Non-Stressful Control Task
Participants assigned to the warm water control condition will perform a non-evaluative task with warm water.
Eligibility Criteria
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Inclusion Criteria
* 18-65 years of age
* Able to speak, read, and write fluently in English
* Be willing and able to follow study procedures and provide informed consent.
Aim 4: To be eligible for participation in this study, an individual must meet all of the following criteria:
* 18-65 years of age
* Diagnosis of GAD
* Able to speak, read, and write fluently in English
* Be willing and able to follow study procedures and provide informed consent.
Exclusion Criteria
* History of or medication for neurologic or psychiatric disease
* High-blood pressure or heart condition
* Diabetes, food allergies, metabolic disorders or history of eating disorder
* Use of corticosteroids or beta-blockers
* Pregnancy
Aim 4: Individuals will be excluded from participation if any of the following criteria are met:
* High-blood pressure or heart condition
* Diabetes, food allergies, metabolic disorders or history of eating disorder
* Use of corticosteroids or beta-blockers
* Lifetime history of bipolar disorder or any psychotic disorder; substance use disorder in past 3 months; eating disorder in past 6 months; current major depressive disorder (past is allowed)
* Active suicidal ideation with plan and intent (indicated by score \>=4 on the Columbia Suicide Severity Scale)
* Not on stable dose of psychiatric medication for at least 4 weeks prior to study participation
* Pregnancy
18 Years
65 Years
ALL
Yes
Sponsors
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NYU Langone Health
OTHER
Responsible Party
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Principal Investigators
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Candace Raio, PhD
Role: PRINCIPAL_INVESTIGATOR
NYU Langone Health
Locations
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NYU Langone Health
New York, New York, United States
Countries
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Central Contacts
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Other Identifiers
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25-01195
Identifier Type: -
Identifier Source: org_study_id