Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
1000 participants
OBSERVATIONAL
2026-01-10
2028-12-21
Brief Summary
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Detailed Description
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Methodology Design: In this single-center, retrospective cohort, consecutive cases were observed from admission to discharge from the ICU. The demographic characteristics, diagnosis type, admission origin, and APACHE II score were systematically calculated on a database, and the cases were divided into two populations for comparison based on the outcome.
Setting: The study was performed in the ICU of Hospital Departamental de Villavicencio, a reference institution for the Orinoco region. It has 350 beds, four adult polyvalent critical care units with 40 beds, and the only oncology unit in the zone.
Patients: Critically ill patients admitted from January 2022 to June 2025 were included.
Sample: The study included all patients in the discharge database and used no sampling method.
Inclusions: All adult patients older than 18 years admitted during the study period were included.
Exclusions: The analysis excluded patients admitted as intermediate care (low therapeutic intervention with a TISS \[Therapeutic Intervention Scoring System\]-28 score below 20 points).
Data collection: The information of all patients admitted to the ICU was systematically collected from the clinical chart on discharge and uploaded to an electronic database in a standardized online format. The severity score was calculated within the first 24 hours of admission. Demographic characteristics, insurance, diagnosis information, APACHE II score, TISS-28 score, mechanical ventilation duration, and outcome were recorded. The outcomes evaluated were mortality (early or late), ICU length of stay, and mechanical ventilation duration.
Analysis plan: The investigators used Jamovi 2.6.44 program for the analysis, and Prism 10.6.1 or Wizard 1.9.49 for the graphics. Categorical variables are presented as frequencies and proportions; continuous variables are presented as their central tendency and dispersion, after verifying normality. The Chi-square test was selected to compare categorical variables, and the t-test or the Mann-Whitney test to compare quantitative variables. A value of p \< 0.01 was chosen as statistical significance. A logistic regression analysis was performed to confirm the effect of APACHE II score on the outcome. Observed mortality rate (early or late \[more than 48 hours) was compared with the expected rate (standardized or SMR). The discrimination of the score was determined by the area under the curve (AUC) of the receiver operating characteristic (ROC), with a closer value to 1 for diagnosis and type of admission.
Ethical aspects: The hospital research committee previously approved the database analysis and waived informed consent, as the study was classified as low-risk research in accordance with national regulations. The project was registered on the platform ClinicalTrials.gov in accordance with the Helsinki Declaration, including observational trials.
Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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ICU mortality
Patients who died in the intensive care unit within the first 28 days of admission.
Exposure factors
Evaluation of factors associated with mortality
ICU survivors
Patients discharged from the intensive care unit alive within the first 24 days.
Exposure factors
Evaluation of factors associated with mortality
Interventions
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Exposure factors
Evaluation of factors associated with mortality
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
100 Years
ALL
No
Sponsors
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Hospital Departamental de Villavicencio
OTHER
Responsible Party
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Norton Perez-Gutierrez, MD
ICU director
Principal Investigators
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Norton Perez Gutierrez, MD
Role: PRINCIPAL_INVESTIGATOR
Hospital Departamental de Villavicencio
Locations
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Hospital Departamental de Villavicencio
Villavicencio, Meta Department, Colombia
Countries
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Central Contacts
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References
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Sudarsanan S, Sivadasan P, Chandra P, Omar AS, Gaviola Atuel KL, Ulla Lone H, Ragab HO, Ehsan I, Carr CS, Pattath AR, Alkhulaifi AM, Shouman Y, Almulla A. Comparison of Four Intensive Care Scores in Predicting Outcomes After Venoarterial Extracorporeal Membrane Oxygenation: A Single-center Retrospective Study. J Cardiothorac Vasc Anesth. 2025 Jan;39(1):131-142. doi: 10.1053/j.jvca.2024.10.027. Epub 2024 Oct 22.
Li X, Yi Q, Luo Y, Wei H, Ge H, Liu H, Zhang J, Li X, Xie X, Pan P, Zhou H, Liu L, Zhou C, Zhang J, Peng L, Pu J, Yuan J, Chen X, Tang Y, Zhou H. Prediction Model of In-Hospital Death for Acute Exacerbation of Chronic Obstructive Pulmonary Disease Patients Admitted to Intensive Care Unit: The PD-ICU Score. Respiration. 2025;104(2):85-99. doi: 10.1159/000541367. Epub 2024 Sep 11.
Knaus WA, Zimmerman JE, Wagner DP, Draper EA, Lawrence DE. APACHE-acute physiology and chronic health evaluation: a physiologically based classification system. Crit Care Med. 1981 Aug;9(8):591-7. doi: 10.1097/00003246-198108000-00008.
Chlabicz M, Laguna W, Kazimierczyk R, Kazimierczyk E, Lopatowska P, Gil M, Sobkowicz B, Kaminski KA, Tycinska A. Value of APACHE II, SOFA and CardShock scoring as predictive tools for cardiogenic shock: A single-centre pilot study. ESC Heart Fail. 2024 Dec;11(6):3584-3597. doi: 10.1002/ehf2.15020. Epub 2024 Aug 13.
Liengswangwong W, Siriwannabhorn R, Leela-Amornsin S, Yuksen C, Sanguanwit P, Duangsri C, Kusonkhum N, Saelim P. Comparison of Modified Early Warning Score (MEWS), Simplified Acute Physiology Score II (SAPS II), Sequential Organ Failure Assessment (SOFA), and Acute Physiology and Chronic Health Evaluation II (APACHE II) for early prediction of septic shock in diabetic patients in Emergency Departments. BMC Emerg Med. 2024 Sep 4;24(1):161. doi: 10.1186/s12873-024-01078-8.
Tekin B, Kilic J, Taskin G, Solmaz I, Tezel O, Basgoz BB. The Comparison of scoring systems: SOFA, APACHE-II, LODS, MODS, and SAPS-II in critically ill elderly sepsis patients. J Infect Dev Ctries. 2024 Jan 31;18(1):122-130. doi: 10.3855/jidc.18526.
Other Identifiers
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GRIVI_2025_02_UCI_MORTAL
Identifier Type: -
Identifier Source: org_study_id