Ejaculatory Behavior and Seminal Vesicle Size During Radical Prostatectomy
NCT ID: NCT07243795
Last Updated: 2025-12-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
40 participants
INTERVENTIONAL
2025-12-01
2026-10-09
Brief Summary
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Does ejaculation within 36 hours before surgery reduce seminal vesicle size compared to abstinence of 72 hours or more?
Does seminal vesicle size affect the ease or difficulty of surgical dissection during radical prostatectomy?
Researchers will compare an ejaculation group to an abstinence group to see if seminal vesicle volume and intraoperative surgical parameters differ between them.
Participants will:
Follow specific instructions to either ejaculate or abstain before surgery
Undergo a transrectal ultrasound (TRUS) to measure seminal vesicle size after anesthesia but before surgery
Have their surgical dissection time and difficulty rated by the operating surgeon
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Detailed Description
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Recent imaging studies suggest that ejaculatory activity significantly affects SV size. In particular, abstinence has been associated with larger SV volumes on MRI and TRUS, while ejaculation may lead to temporary SV shrinkage. These physiological changes, though well-documented radiologically, have not been systematically studied in a surgical setting.
This trial aims to explore whether ejaculatory behavior in the days before RP alters the surgical anatomy and impacts dissection-related metrics. Forty adult male patients with biopsy-confirmed prostate cancer, scheduled for RP, will be randomized in a 1:1 ratio into two groups:
Ejaculation group: At least one ejaculation within 36 hours preoperatively.
Abstinence group: No ejaculation for ≥72 hours before surgery.
Under anesthesia and prior to surgery, transrectal ultrasound (TRUS) will be performed to measure bilateral SV dimensions. The average volume will serve as the primary endpoint. Intraoperative outcomes include dissection time, visual clarity, and perceived difficulty rated by the primary surgeon using a Likert scale. SV volume from final pathology reports will also be collected and compared.
This is a low-risk, behavior-based interventional study involving no experimental drug or device. The main purpose is to assess whether preoperative sexual behavior can be optimized to improve surgical planning and efficiency. Alpha-blocker usage and other potential confounders will be documented and adjusted for in the analysis.
If significant anatomical or procedural differences are observed, findings from this study may inform future multicenter research and guide preoperative patient counseling for RP.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
HEALTH_SERVICES_RESEARCH
SINGLE
Study Groups
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Recent Ejaculation Group
Participants in this group will be instructed to have at least one ejaculation within 36 hours before surgery. Under anesthesia, they will undergo transrectal ultrasound (TRUS) to measure seminal vesicle volume prior to radical prostatectomy. Intraoperative dissection time, difficulty, and visual clarity will also be recorded.
Recent Ejaculation
Participants are instructed to ejaculate at least once within 36 hours prior to radical prostatectomy. This behavioral intervention is used to evaluate its effect on seminal vesicle volume and intraoperative dissection parameters.
Abstinence Group
Participants in this group will be instructed to abstain from ejaculation for at least 72 hours before surgery. Under anesthesia, they will undergo transrectal ultrasound (TRUS) to measure seminal vesicle volume prior to radical prostatectomy. Intraoperative dissection time, difficulty, and visual clarity will also be recorded.
Preoperative Abstinence
Participants are instructed to abstain from ejaculation for at least 72 hours prior to radical prostatectomy. This behavioral intervention is used to assess whether prolonged seminal vesicle filling affects intraoperative anatomy and dissection.
Interventions
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Recent Ejaculation
Participants are instructed to ejaculate at least once within 36 hours prior to radical prostatectomy. This behavioral intervention is used to evaluate its effect on seminal vesicle volume and intraoperative dissection parameters.
Preoperative Abstinence
Participants are instructed to abstain from ejaculation for at least 72 hours prior to radical prostatectomy. This behavioral intervention is used to assess whether prolonged seminal vesicle filling affects intraoperative anatomy and dissection.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Histologically confirmed prostate cancer
* Scheduled for radical prostatectomy
* Able and willing to comply with assigned ejaculation or abstinence protocol
* Willing to complete preoperative questionnaire
* Willing to undergo transrectal ultrasound (TRUS) 12-14 hours before surgery
* Able to understand and sign informed consent
Exclusion Criteria
* Anatomical abnormalities preventing SV identification
* Hormone therapy within 6 months before surgery
* Inability to recall ejaculation history in the past 3 days
* Inability to follow behavioral instructions or TRUS protocol
* Severe anorectal disease or history of anorectal surgery preventing TRUS
* Cognitive or psychiatric conditions impairing informed consent
* Incomplete data or poor-quality imaging
* Prior prostate cancer treatment
* Belonging to a vulnerable population (e.g., minors, prisoners, pregnant individuals, cognitively impaired, etc.)
18 Years
MALE
No
Sponsors
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National Taiwan University Hospital
OTHER
Responsible Party
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Locations
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National Taiwan University Cancer Center
Taipei, Outside U.S./Canada, Taiwan
Countries
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Central Contacts
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Facility Contacts
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References
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Medved M, Sammet S, Yousuf A, Oto A. MR imaging of the prostate and adjacent anatomic structures before, during, and after ejaculation: qualitative and quantitative evaluation. Radiology. 2014 May;271(2):452-60. doi: 10.1148/radiol.14131374. Epub 2014 Feb 1.
Shin T, Kaji Y, Shukuya T, Nozaki M, Soh S, Okada H. Significant changes of T2 value in the peripheral zone and seminal vesicles after ejaculation. Eur Radiol. 2018 Mar;28(3):1009-1015. doi: 10.1007/s00330-017-5077-4. Epub 2017 Oct 6.
Yuruk E, Pastuszak AW, Suggs JM 3rd, Colakerol A, Serefoglu EC. The association between seminal vesicle size and duration of abstinence from ejaculation. Andrologia. 2017 Sep;49(7):10.1111/and.12707. doi: 10.1111/and.12707. Epub 2016 Sep 23.
Other Identifiers
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202507191RINA
Identifier Type: -
Identifier Source: org_study_id
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