Asiaticoside for Treating Overweight/Obesity

NCT ID: NCT07241533

Last Updated: 2025-12-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-12-01

Study Completion Date

2026-11-30

Brief Summary

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Centella asiatica is a traditional herbal medicine widely used in China and Southeast Asia for treating various conditions. Preclinical studies have shown that madecassic acid glycosides, including asiaticoside and madecassoside, can significantly reduce body weight gain, adipose tissue mass, and serum triglyceride levels in high-fat diet-induced obese mice. These compounds also improve hepatic steatosis and insulin resistance. This exploratory, interventional study aims to evaluate the clinical efficacy of orally administered asiaticoside tablets in adults with overweight or obesity.

Detailed Description

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Conditions

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Overweight , Obesity

Keywords

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obesity

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Intervention Arm

Participants take Asiaticoside tablets 60mg tid for 12 weeks

Group Type EXPERIMENTAL

Asiaticoside tablets

Intervention Type DRUG

Asiaticoside tablets 60mg tid for 12 weeks

Interventions

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Asiaticoside tablets

Asiaticoside tablets 60mg tid for 12 weeks

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Adults aged 18 years or older, male or female.
* Overweight or obesity, defined as a body mass index (BMI) of 24.0-45.0 kg/m².
* Able and willing to provide written informed consent.

Exclusion Criteria

* Active pulmonary tuberculosis, malignant tumors, human immunodeficiency virus (HIV) infection, or other severe infectious or immunocompromising conditions.
* Severe liver injury (AST or ALT \> 3 times the upper limit of normal) or severe renal dysfunction/end-stage renal disease (eGFR \< 30 mL/min/1.73 m²).
* Severe cardiovascular diseases, including angina pectoris, myocardial infarction, or stroke within the past 6 months.
* Severe gastrointestinal disorders, or a history of gastrointestinal surgery within the past year.
* Secondary causes of obesity, including Cushing's syndrome, primary hypothyroidism, hypothalamic obesity, acromegaly; or drug-induced obesity (e.g., antipsychotics, glucocorticoids).
* Currently receiving other anti-obesity treatments, a previous history of bariatric surgery, or a \>5% reduction in body weight within the past 3 months.
* Current smoker or habitual smoker within the past 3 months.
* type 1 or type 2 diabetes mellitus or currently taking hypoglycemic medications.
* Pregnancy or planning pregnancy, or breastfeeding.
* Unable to complete a 3-month follow-up due to health conditions or relocation.
* Participation in any clinical study within the past 4 weeks.
* Other conditions considered by investigators as unsuitable for participation.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Shanghai Zhongshan Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Zhongshan Hospital, Fudan University

Shanghai, Shanghai Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Jingjing JIANG, MD, PhD

Role: CONTACT

Phone: 86-021-64041990

Email: [email protected]

Facility Contacts

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JINGJING JIANG, MD, PhD

Role: primary

Other Identifiers

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B2025-710

Identifier Type: -

Identifier Source: org_study_id