Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
134 participants
INTERVENTIONAL
2025-11-24
2026-09-30
Brief Summary
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（1）Does xylitol gum help to reduce cigarette consumption and promote smoking cessation?
Researchers will compare 4-week xylitol gum intervention to the brief advice to see if xylitol gum works to promote smoking cessation.
Participants in the intervention group will receive a 3-month behavioral intervention comprising a 4-week xylitol gum aligned with 12 weeks of instant reminder message support.
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Detailed Description
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A total of 134 participants will be recruited from community settings, including public housing estates across Hong Kong's 18 districts, community and university smoking hotspots, referrals from other smoking cessation programmes, and social media promotions (Facebook and Instagram). The study will adopt a hybrid type I effectiveness-implementation design. Participants will be followed up at 1, 3, and 6 months post-enrolment via telephone, following CONSORT guidelines, to assess cigarette reduction and cessation outcomes.
All participants will receive brief smoking cessation advice at baseline using the AWARD model (Ask/Assess, Warn, Advise, Refer, and Do-it-again), accompanied by a health warning leaflet and a smoking cessation information booklet.
Interventions are as follows:
Chewing gum group (intervention): Participants will receive 4 packs of xylitol gum at baseline and up to 24 packs throughout the 12-week intervention. Approximately 24 reminder messages (two per week), developed based on the Love and Care Approach framework, will be delivered via instant messaging to reinforce motivation and adherence.
Unassisted quitting group (control): Participants will receive brief advice only at baseline.
To explore user experience and acceptability, semi-structured qualitative interviews will be conducted with 20 intervention-group participants to understand their perceptions and experiences with xylitol gum use.
The primary outcome is biochemically validated smoking abstinence at 6 months, defined as exhaled carbon monoxide \<4 ppm and salivary cotinine \<30 ng/mL.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
SINGLE
Study Groups
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Intervention group
Participants assigned to the intervention group will receive a 3-month behavioral intervention comprising a 4-week xylitol gum aligned with 12 weeks of instant reminder message support.
Brief smoking cessation advice
Brief smoking cessation advice guided by the validated AWARD model (Assess, Warning, Advice, Refer, and Do-it-again).
Warning leaflet
The warning leaflet contains pictorial depictions of the adverse health effects of smoking.
Self-help smoking cessation booklet
The self-help smoking cessation booklet includes commonly used smoking cessation strategies.
4-week xylitol gum intervention
Participants in the intervention group will receive 4 packs of xylitol gum (approximately US $2 per pack) at baseline and will be encouraged to use it when they experience cravings.
Instructional leaflet
The instructional leaflet includes the potential benefits of xylitol gum for smoking cessation, recommended timing and dosage for use, and appropriate disposal of used gum.
12-week instant message support
Approximately 24 reminder messages (two per week), developed based on the Love and Care Approach framework, will be delivered over the 12-week period to reinforce motivation and adherence.
Control group
Participants in the control group will receive brief SC advice and a SC information booklet at baseline, which had been routinely used in our previous trials.
Brief smoking cessation advice
Brief smoking cessation advice guided by the validated AWARD model (Assess, Warning, Advice, Refer, and Do-it-again).
Warning leaflet
The warning leaflet contains pictorial depictions of the adverse health effects of smoking.
Self-help smoking cessation booklet
The self-help smoking cessation booklet includes commonly used smoking cessation strategies.
Interventions
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Brief smoking cessation advice
Brief smoking cessation advice guided by the validated AWARD model (Assess, Warning, Advice, Refer, and Do-it-again).
Warning leaflet
The warning leaflet contains pictorial depictions of the adverse health effects of smoking.
Self-help smoking cessation booklet
The self-help smoking cessation booklet includes commonly used smoking cessation strategies.
4-week xylitol gum intervention
Participants in the intervention group will receive 4 packs of xylitol gum (approximately US $2 per pack) at baseline and will be encouraged to use it when they experience cravings.
Instructional leaflet
The instructional leaflet includes the potential benefits of xylitol gum for smoking cessation, recommended timing and dosage for use, and appropriate disposal of used gum.
12-week instant message support
Approximately 24 reminder messages (two per week), developed based on the Love and Care Approach framework, will be delivered over the 12-week period to reinforce motivation and adherence.
Eligibility Criteria
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Inclusion Criteria
* Have the habit of chewing gum or are willing to use chewing gum
* Can communicate in Cantonese (including reading Chinese)
* Express an intention to quit or reduce smoking
* Capable of using instant messaging tools (e.g., WhatsApp, WeChat) for communication
Exclusion Criteria
* Currently participating in other smoking cessation programs or services
18 Years
ALL
No
Sponsors
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The University of Hong Kong
OTHER
Responsible Party
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Prof. Wang Man-Ping
Professor
Principal Investigators
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Man Ping Wang, PhD
Role: PRINCIPAL_INVESTIGATOR
The University of Hong Kong
Locations
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School of Nursing, The University of Hong Kong
Hong Kong, , Hong Kong
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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Chew 2 quit
Identifier Type: -
Identifier Source: org_study_id
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