Towards Restoring Complex Movement After Paralysis: Algorithm Development With Healthy Participants

NCT ID: NCT07236892

Last Updated: 2025-12-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-11-26

Study Completion Date

2029-12-01

Brief Summary

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Participants will perform experiments with non-invasive activity recordings. The study will record from multiple non-invasive signal sources that reflect motor intent that may include: electroencephalography (EEG), electromyography (EMG), functional near infrared spectroscopy (fNIRS), inertial measurement units (IMUs), eye movements, pupil size, and speech. Participants will wear all or a subset of these sensors and be asked to perform, imagine, or attempt movements or speech. The recorded sensor signals will be decoded to help guide an end effector, which may be a computer, robotic arm, wheelchair, or other assistive device.

These experiments present minimal risk and participants may withdraw participation at any time for any reason. Participants may return for additional experiments if desired and to perform additional comparisons. If a participant withdraws during a comparison, another participant will be recruited to complete collection of data for that comparison.

Detailed Description

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Conditions

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Movement Disorders Neurorehabilitation Non-invasive Activity Recording

Keywords

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Machine Learning Algorithm Development

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Healthy Participants

Participants will perform a subset of tasks while non-invasive activity is recorded which may include EEG, EMG, IMUs, fNIRS, eye gaze, or pupillometry.

Group Type EXPERIMENTAL

Participants will perform experimental tasks while undergoing non-invasive activity recordings, which may include EEG, EMG, IMUs, fNIRS, eye gaze, or pupillometry.

Intervention Type BEHAVIORAL

Participants may be prompted to imagine, attempt, or perform actions while a task is being performed on a computer, robotic arm, wheelchair, or exoskeleton. Participants may also autonomously perform actions to control each end effector. Participants may be asked to control a cursor to acquire a target or multiple targets. Participants may be asked to pick and place various objects, interact with articulated objects, or perform other motor tasks using a robotic manipulator. Participants may be asked to navigate a wheelchair.

Interventions

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Participants will perform experimental tasks while undergoing non-invasive activity recordings, which may include EEG, EMG, IMUs, fNIRS, eye gaze, or pupillometry.

Participants may be prompted to imagine, attempt, or perform actions while a task is being performed on a computer, robotic arm, wheelchair, or exoskeleton. Participants may also autonomously perform actions to control each end effector. Participants may be asked to control a cursor to acquire a target or multiple targets. Participants may be asked to pick and place various objects, interact with articulated objects, or perform other motor tasks using a robotic manipulator. Participants may be asked to navigate a wheelchair.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Fluent in the English language

Exclusion Criteria

* Neurological injury or disease that results in functional paralysis
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NIH

Sponsor Role collaborator

University of California, Los Angeles

OTHER

Sponsor Role lead

Responsible Party

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Jonathan Kao

Associate Professor, UCLA ECE & CS

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jonathan Kao, PhD

Role: PRINCIPAL_INVESTIGATOR

UCLA Neural Engineering and Computation Lab

Locations

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UCLA Neural Engineering and Computation Lab

Los Angeles, California, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Restoring Movement Study Coordinator

Role: CONTACT

Email: [email protected]

Facility Contacts

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Restoring Movement Study Coordinator

Role: primary

Other Identifiers

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1DP1HD121548-01

Identifier Type: NIH

Identifier Source: secondary_id

View Link

25-1072

Identifier Type: -

Identifier Source: org_study_id