Superficial Cervical Plexus Block Versus Ketamine in the Prevention of Chronic Pain After Thyroidectomy

NCT ID: NCT07230392

Last Updated: 2025-11-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

69 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-10-14

Study Completion Date

2025-07-05

Brief Summary

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The goal of our work is to to compare the effect of preemptive Ketamine administration versus superficial cervical plexus block on the incidence of postoperative neuropathic pain in patients undergoing thyroidectomy

Detailed Description

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Conditions

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Chronic Pain Thyroidectomy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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BCS Group

Patients received a bilateral ultrasound-guided superficial cervical plexus block after induction (Ropivacaine 0.2%,with a volume of 10 mL administered to each side)

Group Type ACTIVE_COMPARATOR

Superficial cervical plexus block

Intervention Type PROCEDURE

Bilateral ultrasound-guided superficial cervical plexus block after induction(Ropivacaine 0.2% Ropivacaine 0.2%, with a volume of 10 mL administered to each side) was performed for patients of this group

KETA group

Patients received intravenous ketamine (0.25 mg/kg bolus followed by a 2 µg/kg/min infusion).

Group Type ACTIVE_COMPARATOR

Ketamine perfusion

Intervention Type DRUG

Intravenous ketamine 0.25 mg/kg bolus followed by a 2 µg/kg/min infusion

Interventions

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Ketamine perfusion

Intravenous ketamine 0.25 mg/kg bolus followed by a 2 µg/kg/min infusion

Intervention Type DRUG

Superficial cervical plexus block

Bilateral ultrasound-guided superficial cervical plexus block after induction(Ropivacaine 0.2% Ropivacaine 0.2%, with a volume of 10 mL administered to each side) was performed for patients of this group

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Adults aged 18 to 80 years
* Scheduled for thyroidectomy under general anesthesia.
* American Society of Anesthesiologists (ASA) physical status I-III.
* Able to understand the study procedures and provide written informed consent

Exclusion Criteria

* Known allergy to ketamine or local anesthetics
* Severe renal impairment with estimated Glomerular Filtration Rate (eGFR) under 30 mL/min
* History of neurological disorders
* History of psychiatric illness
* History of severe cardiac disease (NYHA III-IV) or serious arrhythmias
* Pregnancy or breastfeeding
* Morbid obesity (BMI \> 40 kg/m²)
* Cognitive or communication impairment
* Refusal to participate
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Tunis El Manar

OTHER

Sponsor Role lead

Responsible Party

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Ben Taleb Ibtissem

Assistant Professor in Anesthesiology and Intensive Care

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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ibtissem BEN TALEB

Role: PRINCIPAL_INVESTIGATOR

University of Tunis El Manar, Anesthesia and critical care department, Taher Maamouri University Hospital,

Locations

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Mohamed Taher Maamouri University Hospital

Nabeul, Nabeul Governorate, Tunisia

Site Status

Countries

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Tunisia

Other Identifiers

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Thyrobloket

Identifier Type: -

Identifier Source: org_study_id

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