Evaluating Mammography Communication Approaches

NCT ID: NCT07228234

Last Updated: 2026-01-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

1900 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-11-06

Study Completion Date

2027-11-30

Brief Summary

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This is a randomized online experiment testing different methods for communicating about the benefits and harms of breast cancer screening. Participants will be randomly assigned to experimental conditions which vary whether screening outcomes are referred to as "benefits and harms" vs. "outcomes that can happen with screening", and vary the presence or absence of information about improvements in breast cancer survivability. In a control condition, participants receive basic information about what mammography is (which is also information received in all other conditions). Primary outcomes include skepticism toward the information presented, and screening intentions.

Detailed Description

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This is a randomized online experiment testing different methods for communicating about the benefits and harms of breast cancer screening. Participants will be randomly assigned to 1 of 5 experimental conditions, in a 2 x 2 + 1 factorial design, which vary (1) whether screening outcomes are referred to as "benefits and harms" vs. "outcomes that can happen with screening", and (2) the presence or absence of information about improvements in breast cancer treatment and survivability. In a 5th arm, a control condition, participants receive basic information about what mammography is (which is also information received in all other conditions). Primary outcomes include skepticism toward the information presented, and screening intentions.

Conditions

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The Focus of This Study is to Identify How Different Approaches to Mammography Communication Affect Skepticism Toward Mammography Evidence

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

This is a 2 x 2 +1 randomized factorial design. Participants will be randomly assigned to 1 of 5 experimental conditions, which vary (1) whether screening outcomes are referred to as "benefits and harms" vs. "outcomes that can happen with screening", and (2) the presence or absence of information about improvements in breast cancer treatment and survivability. In a 5th arm, a control condition, participants receive basic information about what mammography is (which is also information received in all other conditions).
Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

SINGLE

Participants

Study Groups

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Control condition

Participants receive basic information about what mammography screening is

Group Type EXPERIMENTAL

No intervention

Intervention Type OTHER

This is the control condition in which only basic information about mammography screening.

Harm/benefit language, survivability information

Outcomes of screening are referred to as "harms" and "benefits"; information about breast cancer survivability is included

Group Type EXPERIMENTAL

Harm/benefit language vs. outcomes that can happen

Intervention Type OTHER

Information about mortality benefit, false positives and overdiagnosis are referred to throughout the communication as either "harms" and "benefits" or "outcomes that can happen".

Breast cancer survivability information

Intervention Type OTHER

Information about improvements over time in the survivability of breast cancer is provided vs. not

Harm/benefit language, no survivability information

Outcomes of screening are referred to as "harms" and "benefits"; information about breast cancer survivability is not included

Group Type EXPERIMENTAL

Harm/benefit language vs. outcomes that can happen

Intervention Type OTHER

Information about mortality benefit, false positives and overdiagnosis are referred to throughout the communication as either "harms" and "benefits" or "outcomes that can happen".

Outcomes that can happen language, survivability information

Outcomes of screening are referred to as "outcomes that can happen"; information about breast cancer survivability is included

Group Type EXPERIMENTAL

Harm/benefit language vs. outcomes that can happen

Intervention Type OTHER

Information about mortality benefit, false positives and overdiagnosis are referred to throughout the communication as either "harms" and "benefits" or "outcomes that can happen".

Breast cancer survivability information

Intervention Type OTHER

Information about improvements over time in the survivability of breast cancer is provided vs. not

Outcomes that can happen language, no survivability information

Outcomes of screening are referred to as "outcomes that can happen"; information about breast cancer survivability is not included

Group Type EXPERIMENTAL

Harm/benefit language vs. outcomes that can happen

Intervention Type OTHER

Information about mortality benefit, false positives and overdiagnosis are referred to throughout the communication as either "harms" and "benefits" or "outcomes that can happen".

Interventions

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Harm/benefit language vs. outcomes that can happen

Information about mortality benefit, false positives and overdiagnosis are referred to throughout the communication as either "harms" and "benefits" or "outcomes that can happen".

Intervention Type OTHER

Breast cancer survivability information

Information about improvements over time in the survivability of breast cancer is provided vs. not

Intervention Type OTHER

No intervention

This is the control condition in which only basic information about mammography screening.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Female, age 39-49

Exclusion Criteria

* No history of breast cancer, no known BRCA1/2 gene mutation
Minimum Eligible Age

39 Years

Maximum Eligible Age

49 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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National Cancer Institute (NCI)

NIH

Sponsor Role collaborator

University of Colorado, Denver

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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University of Colorado Anschutz

Aurora, Colorado, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Laura D Scherer, PhD

Role: CONTACT

303-724-3278

Tamar Parmet, MA

Role: CONTACT

303-724-3278

Other Identifiers

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R37CA254926

Identifier Type: NIH

Identifier Source: secondary_id

View Link

25-0635

Identifier Type: -

Identifier Source: org_study_id

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