A Study of LY3938577 in Participants With Type 2 Diabetes Previously Treated With Basal Insulin

NCT ID: NCT07215312

Last Updated: 2025-12-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE2

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-10-13

Study Completion Date

2026-12-31

Brief Summary

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The purpose of this study is to see how well LY3938577 works and how safe it is compared to degludec in people with type 2 diabetes. Participation in the study will last about 26 weeks.

Detailed Description

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Conditions

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Diabetes Mellitus, Type 2

Keywords

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Glycemic control Hypoglycemia Hyperglycemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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LY3938577

Participants will receive LY3938577 subcutaneously (SC)

Group Type EXPERIMENTAL

LY3938577

Intervention Type DRUG

Administered SC

Degludec

Participants will receive degludec SC

Group Type ACTIVE_COMPARATOR

Degludec

Intervention Type DRUG

Administered SC

Interventions

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LY3938577

Administered SC

Intervention Type DRUG

Degludec

Administered SC

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Have type 2 diabetes
* Are receiving ≥20 units of basal insulin per day and ≤55 units/day and ≤1.5 units/kg/day at screening
* Have hemoglobin A1c (HbA1c) 7.5% to 10.5% inclusive
* Have a body mass index (BMI) of 20 or higher and less than 35 kilograms per square meter (kg/m2)

Exclusion Criteria

* Have type 1 diabetes
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Eli Lilly and Company

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST)

Role: STUDY_DIRECTOR

Eli Lilly and Company

Locations

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Tucson Clinical Research Institute

Tucson, Arizona, United States

Site Status RECRUITING

Encompass Clinical Research

Spring Valley, California, United States

Site Status RECRUITING

University Clinical Investigators, Inc.

Tustin, California, United States

Site Status RECRUITING

Tampa Bay Medical Research

Clearwater, Florida, United States

Site Status RECRUITING

Encore Medical Research

Hollywood, Florida, United States

Site Status RECRUITING

Clinical Research of Central Florida

Lakeland, Florida, United States

Site Status RECRUITING

Encore Medical Research - Weston

Weston, Florida, United States

Site Status RECRUITING

Iowa Diabetes and Endocrinology Research Center

West Des Moines, Iowa, United States

Site Status RECRUITING

Washington University School of Medicine

St Louis, Missouri, United States

Site Status RECRUITING

Accellacare - Wilmington

Wilmington, North Carolina, United States

Site Status RECRUITING

AMR Clinical

Norman, Oklahoma, United States

Site Status RECRUITING

Tribe Clinical Research, LLC

Greenville, South Carolina, United States

Site Status RECRUITING

Holston Medical Group

Bristol, Tennessee, United States

Site Status RECRUITING

Texas Diabetes & Endocrinology, P.A.

Austin, Texas, United States

Site Status RECRUITING

Velocity Clinical Research, Dallas

Dallas, Texas, United States

Site Status RECRUITING

Juno Research

Houston, Texas, United States

Site Status RECRUITING

Southern Endocrinology Associates

Mesquite, Texas, United States

Site Status RECRUITING

Consano Clinical Research, LLC

Shavano Park, Texas, United States

Site Status RECRUITING

Texas Valley Clinical Research

Weslaco, Texas, United States

Site Status RECRUITING

Chrysalis Clinical Research

St. George, Utah, United States

Site Status RECRUITING

CIPREC

Buenos Aires, , Argentina

Site Status RECRUITING

Mautalen Salud e Investigación

Buenos Aires, , Argentina

Site Status RECRUITING

Consultorio de Investigación Clínica EMO SRL

Buenos Aires, , Argentina

Site Status RECRUITING

Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada

Buenos Aires, , Argentina

Site Status RECRUITING

Instituto Centenario

CABA, , Argentina

Site Status RECRUITING

Instituto Médico Catamarca IMEC

Rosario, , Argentina

Site Status RECRUITING

Countries

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United States Argentina

Central Contacts

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Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or

Role: CONTACT

Phone: 317-615-4559

Email: [email protected]

Physicians interested in becoming principal investigators please contact

Role: CONTACT

Email: [email protected]

Facility Contacts

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Role: primary

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Related Links

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https://trials.lilly.com/en-US/trial/659897

A Study of LY3938577 in Participants With Type 2 Diabetes Previously Treated With Basal Insulin

Other Identifiers

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J4P-MC-IYAC

Identifier Type: OTHER

Identifier Source: secondary_id

27409

Identifier Type: -

Identifier Source: org_study_id