Ultrasound Use to Measure Magnetically Controlled Growing Rods

NCT ID: NCT07212049

Last Updated: 2025-11-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-09-05

Study Completion Date

2026-09-05

Brief Summary

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The goal of this clinical trial is to learn if an ultrasound can measure the length of an internal tibia and femur lengthening rod. The main questions it aims to answer are:

Can an ultrasound be used to measure the length of an internal magnetic lengthening nail in a tibia or femur? Can an ultrasound measure the rod lengthening as well as an ultrasound? Researchers will compare the length of an internal magnetic lengthening rod with both x-rays and ultrasound

Participants will:

Have standard x-rays every week They will also have an ultrasound of the femur or tibia

Detailed Description

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Limb lengthening with expanding intramedullary rods has become the standard of care for limb lengthening procedures. The procedure entails performing an osteotomy of the short bone and placing a mechanical expanding intramedullary nail. The aim of the study is to explore the role of ultrasound to measure tibia and femur lengthening procedures and compare the accuracy to standard radiographs.

The study design is a prospective, pilot study of 5 tibias and 5 femurs. Measurements of the femurs and tibias will be obtained in 3 separate locations to try to identify areas that can be visualized and measured by an ultrasound. The cost of the ultrasound will be compared to the cost of x-rays, and any pain regarding imaging modalities will also be compared

Conditions

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Limb Length Discrepancy

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Ultrasound of lengthening rod

All patients will have an ultrasound measuring the lengthen of the internal rod

Group Type EXPERIMENTAL

ultrasound measurement

Intervention Type DEVICE

Three different measurements will be obtained using an ultrasound to determine the length gained from lengthening the tibia and/or femur with an internal lengthening rod. Please see the protocol on the locations that will me measured.

X-ray imaging of tibia and/or femur

Intervention Type DIAGNOSTIC_TEST

All patients will have an x-ray with two views anterior-posterior and lateral to measuring the lengthening of the internal rod. Please see the protocol for locations of the measurements being obtained.

Interventions

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ultrasound measurement

Three different measurements will be obtained using an ultrasound to determine the length gained from lengthening the tibia and/or femur with an internal lengthening rod. Please see the protocol on the locations that will me measured.

Intervention Type DEVICE

X-ray imaging of tibia and/or femur

All patients will have an x-ray with two views anterior-posterior and lateral to measuring the lengthening of the internal rod. Please see the protocol for locations of the measurements being obtained.

Intervention Type DIAGNOSTIC_TEST

Other Intervention Names

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Radiographs

Eligibility Criteria

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Inclusion Criteria

* Patients undergoing tibia or femur lengthening with an intramedullary mechanical rod.

Exclusion Criteria

* Patients who underwent lengthening procedure with any other device such as external fixator.
* Patients under 8 years old and over 21 years of age
Minimum Eligible Age

8 Years

Maximum Eligible Age

21 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Nemours Children's Clinic

OTHER

Sponsor Role lead

Responsible Party

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Jason Malone

Pediatric Orthopedic Surgeon

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Nemours Children's Hospital Florida

Orlando, Florida, United States

Site Status

Countries

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United States

References

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Cheung JP, Bow C, Samartzis D, Ganal-Antonio AK, Cheung KM. Clinical utility of ultrasound to prospectively monitor distraction of magnetically controlled growing rods. Spine J. 2016 Feb;16(2):204-9. doi: 10.1016/j.spinee.2015.10.044. Epub 2015 Oct 30.

Reference Type BACKGROUND
PMID: 26523963 (View on PubMed)

Schiedel FM, Buller TC, Rodl R. Estimation of patient dose and associated radiogenic risks from limb lengthening. Clin Orthop Relat Res. 2009 Apr;467(4):1023-7. doi: 10.1007/s11999-008-0624-6. Epub 2008 Nov 22.

Reference Type BACKGROUND
PMID: 19030942 (View on PubMed)

Laubscher M, Mitchell C, Timms A, Goodier D, Calder P. Outcomes following femoral lengthening: An initial comparison of the Precice intramedullary lengthening nail and the LRS external fixator monorail system. Bone Joint J. 2016 Oct;98-B(10):1382-1388. doi: 10.1302/0301-620X.98B10.36643.

Reference Type BACKGROUND
PMID: 27694593 (View on PubMed)

Stokes OM, O'Donovan EJ, Samartzis D, Bow CH, Luk KD, Cheung KM. Reducing radiation exposure in early-onset scoliosis surgery patients: novel use of ultrasonography to measure lengthening in magnetically-controlled growing rods. Spine J. 2014 Oct 1;14(10):2397-404. doi: 10.1016/j.spinee.2014.01.039. Epub 2014 Jan 31.

Reference Type BACKGROUND
PMID: 24486476 (View on PubMed)

Cobanoglu M, Shah SA, Gabos P, Rogers K, Yorgova P, Neiss G, Grissom L, Mackenzie WG. Comparison of Intended Lengthening of Magnetically Controlled Growing Rods: Ultrasound Versus X-Ray. J Pediatr Orthop. 2019 Feb;39(2):e141-e146. doi: 10.1097/BPO.0000000000001072.

Reference Type BACKGROUND
PMID: 29016427 (View on PubMed)

Yoon WW, Chang AC, Tyler P, Butt S, Raniga S, Noordeen H. The use of ultrasound in comparison to radiography in magnetically controlled growth rod lengthening measurement: a prospective study. Eur Spine J. 2015 Jul;24(7):1422-6. doi: 10.1007/s00586-014-3589-z. Epub 2014 Sep 26.

Reference Type BACKGROUND
PMID: 25256680 (View on PubMed)

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Document Type: Informed Consent Form: 7-11 year old Consent Guardian Assent

View Document

Document Type: Informed Consent Form: 12 to 17 year old assent

View Document

Document Type: Informed Consent Form: 7-11 year old Consent Guardian

View Document

Document Type: Informed Consent Form: consent for adult

View Document

Document Type: Informed Consent Form: 12 to 17 year old Guardian concent

View Document

Other Identifiers

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2169786

Identifier Type: -

Identifier Source: org_study_id

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