Clinical Trial on Rapid Immune Modulating Effects

NCT ID: NCT07206407

Last Updated: 2025-12-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-09-28

Study Completion Date

2026-03-01

Brief Summary

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The goal for this clinical trial is to document rapid effects of a nutritional blend on immune cells. A double-blind, placebo-controlled, cross-over study design will be used.

Detailed Description

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Clinical trial comparing the acute immune effects of a nutraceutical blend, and a placebo. The nutraceutical blend is based on low molecular weight peptides isolated from cow colostrum ultrafiltrate, mushroom extracts, and vitamin C.

24 subjects will participate in a placebo-controlled, randomized, double-blinded, cross-over study design, wherein they will be consuming placebo or the active nutraceutical blend, separated by a 1-week washout period.

Baseline blood samples are taken 1 hour after participants arrive; the dose is then administered. Additional blood samples are taken 1 hour, 2 hours, and 3 hours following consumption of test product.

Conditions

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Immune Surveillance

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Double-blinded, placebo-controlled, cross-over study design.
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Caregivers Investigators
Participants will not be informed on which intervention they consume on a given clinic visit.

Study Groups

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Experimental: Crossover group 1, randomized

Crossover study: Participants consume a test product on each of the two clinic visits, at least 1 week apart, allowing for 1 week wash-out period between each product. Participants will consume the active test product versus placebo over 2 weeks. The order of interventions for this group is A, B.

Group Type EXPERIMENTAL

Placebo

Intervention Type DIETARY_SUPPLEMENT

Four capsules.

Nutraceutical blend

Intervention Type DIETARY_SUPPLEMENT

Four capsules.

Experimental: Crossover group 2, randomized

Crossover study: Participants consume a test product on each of the two clinic visits, at least 1 week apart, allowing for 1 week wash-out period between each product. Participants will consume the active test product versus placebo over 2 weeks. The order of interventions for this group is B, A.

Group Type EXPERIMENTAL

Placebo

Intervention Type DIETARY_SUPPLEMENT

Four capsules.

Nutraceutical blend

Intervention Type DIETARY_SUPPLEMENT

Four capsules.

Interventions

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Placebo

Four capsules.

Intervention Type DIETARY_SUPPLEMENT

Nutraceutical blend

Four capsules.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Healthy adults;
* Age 18-75 years (inclusive);
* Veins easy to see in one or both arms (to allow for the multiple blood draws);
* Willing to comply with study procedures, including:

* Maintaining a consistent diet and lifestyle routine throughout the study,
* Consistent habit of bland breakfasts on days of clinic visits,
* Abstaining from exercising and nutritional supplements on the morning of a study visit,
* Abstaining from use of coffee, tea, and soft drinks for at least one hour prior to a clinic visit;
* Abstaining from music, candy, gum, computer/cell phone use, during clinic visits.

Exclusion Criteria

* Previous major gastrointestinal surgery (absorption of test product may be altered) (minor surgery not a problem, including previous removal of appendix and gall bladder);
* Taking anti-inflammatory medications on a daily basis;
* Currently experiencing intense stressful events/ life changes;
* Currently in intensive athletic training (such as marathon runners);
* Currently taking antipsychotic medications such as clozapine, Risperdal, Abilify, Zyprexa or Seroquel;
* An unusual sleep routine (examples: working graveyard shift, irregular routine with frequent late nights, studying, partying);
* Unwilling to maintain a constant intake of supplements over the duration of the study;
* Anxiety about having blood drawn;
* Pregnant, nursing, or trying to become pregnant;
* Known allergies related to ingredients in active test product or placebo.
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Natural Immune Systems Inc

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Gitte S. Jensen, PhD

Role: PRINCIPAL_INVESTIGATOR

NIS Labs

Locations

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NIS Labs

Klamath Falls, Oregon, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Gitte S. Jensen, PhD

Role: CONTACT

15418840112

Facility Contacts

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Alex S. Cruickshank

Role: primary

(541) 884-0112

Gitte S. Jensen, PhD

Role: backup

Other Identifiers

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058-010

Identifier Type: -

Identifier Source: org_study_id