(TNX-1500) in Kidney Transplant Recipients

NCT ID: NCT07204080

Last Updated: 2025-11-12

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: PHASE2
• Total Enrollment: 5 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2026-01-01
• Study Completion Date: 2028-12-31

Brief Summary

The primary objective is to investigate the safety and efficacy of TNX-1500, an FC-modified anti-CD154 mAb, in five kidney transplant recipients at 12 months.

Conditions

Kidney Transplant; Kidney Transplant Failure and Rejection; Immunosuppression; Immunosuppression After Kidney Transplantation

Keywords

Kidney Transplant; New Immunosuppression

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Kidney Transplant Recipient

Group Type: EXPERIMENTAL

TNX-1500

Intervention Type: DRUG

This is an open-label, single-center, single-arm study to assess the safety and efficacy of TNX-1500, an Fc-modified anti-DF154 mAb in five adult kidney transplant recipients.

Kidney Transplant

Intervention Type: PROCEDURE

Kidney Transplant

Interventions

TNX-1500

This is an open-label, single-center, single-arm study to assess the safety and efficacy of TNX-1500, an Fc-modified anti-DF154 mAb in five adult kidney transplant recipients.

Intervention Type: DRUG

Kidney Transplant

Kidney Transplant

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

1. Male or female subjects ≥18 to 75 years of age.

2. Kidney transplant candidates with chronic kidney disease (stage IV or V) or end-stage kidney disease evaluated and listed for transplantation at Massachusetts General Hospital.

3. Recipient of an ABO-compatible, non-human leukocyte antigen (HLA) identical living or deceased donor kidney (de novo or second transplant)

4. Ability to understand the study requirements and provide written informed consent.

5. Epstein-Barr virus (EBV) seropositive

Exclusion Criteria

1. Recipient seropositive for human immunodeficiency virus (HIV-1), or hepatitis B surface antigen (HBsAg) or core antibody (Anti-HBc); subjects who are seropositive for hepatitis C virus (HCV) are excluded without proof of sustained viral response (SVR) after anti-HCV treatment or spontaneous clearance.

2. Recipient of a kidney from a donor who tests positive for HIV, HBsAg, Anti-HBc, or HCV NAT.

3. Subjects with a severe systemic infection, current or within the 2 weeks prior to screening.

4. Left ventricular ejection fraction < 40% as determined by TTE or clinical evidence of heart failure.

5. Pregnant or nursing (lactating) women confirmed by human chorionic gonadotropin (hCG) laboratory test.

6. Women of childbearing potential (women capable of becoming pregnant) unless using a highly effective method of contraception during dosing and for 24 weeks after study treatment. Highly effective contraception methods include:

1. Female sterilization (surgical, bilateral oophorectomy with or without hysterectomy), or tubal ligation at least 6 weeks before taking study treatment.

2. Male sterilization (at least 6 months prior to screening); for female subjects on the study, the vasectomized male partners should be the sole partners for that subject.

3. Use of injected or implanted hormonal methods of contraception or other hormonal contraception that have comparable efficacy (<1% for example, hormone vaginal ring or placement of a long-acting reversible contraceptives, an intrauterine device, or intrauterine system.

4. Total abstinence

7. Use of other investigational products or enrollment in another investigational drug study within 30 days prior to screening or 5 half-lives, whichever is longer.

8. Subjects with clinically significant lab abnormalities (>2.5 x the upper limit of normal (ULN) of the following liver function chemistries unless due to, as judged by the investigator, a benign underlying condition:

1. Alanine aminotransferase (ALT)

2. Aspartate aminotransferase (AST)

3. Alkaline phosphatase (ALP)

4. Bilirubin

5. Coagulation studies (international normalization ratio (INR), prothrombin time (PT), and partial thromboplastin time (PTT))

9. Any other clinically significant medical condition, active infection, laboratory abnormality, or psychosocial condition (e.g. history of substance use disorder) that would, in the judgement of the investigator, impact the subject's ability to participate in the trial.

10. Subject receives an organ at high risk for delayed graft function, including from a deceased donor after cardiac death (DCD) or a high Kidney Donor Profile Index ≥85%.

11. Presence of pre-existing donor-specific antibodies (DSA) or calculated panel reactive antibodies (cPRA) >20% based upon results within 6 months prior to transplant.

12. Virtual crossmatch (VXM) positive transplant with an MFI >1000 as assessed by routine methodology (Luminex)

13. Cytomegalovirus (CMV) high risk combination: donor positive to recipient negative

14. Multi-organ transplant or tissue recipient.

15. History of malignancy of any organ system, except for localized excised non-melanomatous skin or carcinoma in situ of the cervix

16. Subjects with any of the following: hemoglobin <8 mg/dL, white blood cell ≤2,000/mm3, or platelet count ≤75,000/mm3.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Tonix Pharmaceuticals, Inc.

INDUSTRY

Sponsor Role: collaborator

Ayman Al Jurdi, MD

OTHER

Sponsor Role: lead

Responsible Party

Ayman Al Jurdi, MD

Physician

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

Ayman Al Jurdi, MD

Role: PRINCIPAL_INVESTIGATOR

Massachusetts General Hospital

Locations

Massachusetts General Hospital

Boston, Massachusetts, United States

Massachusetts General Hospital

Boston, Massachusetts, United States

Countries

United States

Central Contacts

Ayman Al Jurdi, Principal Investigator, MD

Role: CONTACT

Phone: 617-726-2000

Email: aaljurdi@mgh.harvard.edu

Facility Contacts

Ayman Al Jurdi

Role: primary

Other Identifiers

2025P-------

Identifier Type: -

Identifier Source: org_study_id