An Observational Study of Glofitamab in Chinese Adult Participants With 2L Diffuse Large B-Cell Lymphoma

NCT ID: NCT07200375

Last Updated: 2026-01-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-09-29

Study Completion Date

2029-09-29

Brief Summary

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This study will investigate how well glofitamab-based therapy works and how safe it is in Chinese adult participants with relapsed or refractory diffuse large B-cell lymphoma (R/R DLBCL).

Detailed Description

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Conditions

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Diffuse Large B-Cell Lymphoma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Glofitamab treatment

Participants will be enrolled into the study either prior to initiation of glofitamab therapy or within 90 days of starting glofitamab therapy.

Glofitamab

Intervention Type DRUG

Participants will receive glofitamab as part of a cancer-treatment regimen in a real-world setting. No intervention will be administered by study investigators.

Interventions

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Glofitamab

Participants will receive glofitamab as part of a cancer-treatment regimen in a real-world setting. No intervention will be administered by study investigators.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Histologically confirmed R/R DLBCL after one line of systemic therapy
* Will be treated with Glofit-based regimen (known as being recommended and having the intention to be treated with Glofitamab at the time of signing ICF) or have initiated Glofit-based regimen treatment within three months (90 days) prior to enrollment

Exclusion Criteria

* Participants who currently participate in or plan to participate in any interventional clinical trial
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hoffmann-La Roche

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Trials

Role: STUDY_DIRECTOR

Hoffmann-La Roche

Locations

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Chinese Academy of Medical Sciences Hematology Hospital;Lymphoma Diagnosis and Treatment Center

Tianjin, Tianjin Municipality, China

Site Status RECRUITING

Peking University Third Hospital

Beijing, , China

Site Status RECRUITING

The First Bethune Hospital of Jilin University

Changchun, , China

Site Status RECRUITING

Ruijin Hospital, Shanghai Jiaotong University School of Medicine

Shanghai, , China

Site Status RECRUITING

Tianjin Cancer Hospital

Tianjin, , China

Site Status RECRUITING

The First Affiliated Hospital of Wenzhou Medical University

Wenzhou, , China

Site Status RECRUITING

Henan Cancer Hospital

Zhengzhou, , China

Site Status RECRUITING

Countries

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China

Central Contacts

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Reference Study ID Number: ML45172 https://forpatients.roche.com/

Role: CONTACT

888-662-6728 (U.S. and Canada)

Other Identifiers

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ML45172

Identifier Type: -

Identifier Source: org_study_id

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