Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
PHASE2
20 participants
INTERVENTIONAL
2026-01-31
2026-07-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
DOUBLE
Study Groups
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Active (TBS) - Sham (TBS)
Block 1: Active TBS Block 2: Sham TBS
Transcranial Magnetic Stimulation
TMS is a non-invasive brain stimulation technique. The primary aim of the study will be to verify the deliverability of the TMS effect on the hippocampus and determine which stimulation protocol is more beneficial to each participant.
Device: Transcranial Magnetic Stimulation (Sham)
TMS is a non-invasive brain stimulation technique. The primary aim of the study will be to verify the deliverability of the TMS effect on the hippocampus and determine which stimulation protocol is more beneficial to each participant. For sham, the side of the coil that does not deliver pulses will be used.
Sham (TBS) - Active (TBS)
Block 1: Sham TBS Block 2: Active TBS
Transcranial Magnetic Stimulation
TMS is a non-invasive brain stimulation technique. The primary aim of the study will be to verify the deliverability of the TMS effect on the hippocampus and determine which stimulation protocol is more beneficial to each participant.
Device: Transcranial Magnetic Stimulation (Sham)
TMS is a non-invasive brain stimulation technique. The primary aim of the study will be to verify the deliverability of the TMS effect on the hippocampus and determine which stimulation protocol is more beneficial to each participant. For sham, the side of the coil that does not deliver pulses will be used.
Interventions
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Transcranial Magnetic Stimulation
TMS is a non-invasive brain stimulation technique. The primary aim of the study will be to verify the deliverability of the TMS effect on the hippocampus and determine which stimulation protocol is more beneficial to each participant.
Device: Transcranial Magnetic Stimulation (Sham)
TMS is a non-invasive brain stimulation technique. The primary aim of the study will be to verify the deliverability of the TMS effect on the hippocampus and determine which stimulation protocol is more beneficial to each participant. For sham, the side of the coil that does not deliver pulses will be used.
Eligibility Criteria
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Inclusion Criteria
* Age 18-85 years
* MCI subjective criteria: self- or informant-reported cognitive complaint
* Objective cognitive impairment supported by one of the following measures of general cognitive function: (a) classified as MCI via the NACC-UDS 3.0 neuropsychological battery using the typical neuropsychological criteria for MCI diagnosis (1 score on any test at least1.5 SD below the mean); or (b) classified as MCI via the NACC-UDS 3.0 neuropsychological battery using the Jak/Bondi neuropsychological criteria for MCI diagnosis(2 scores at least 1 SD below the mean in one domain, or 3 scores at least 1SD below the mean across domains)
* Right-handed
* English speaking
* Able to attend daily intervention and outcome measurements for \~15 days over a 6 month period.
* Not enrolled in another interventional study within 6 months prior to beginning this study
Exclusion Criteria
* Reported sudden or steep decline of cognitive performance
* Telephone Interview for cognitive impairment (TICS) score
* Other neurological disorders (e.g., stroke, head injuries, or multiple sclerosis)
* Psychiatric disorder (except stable late-life depression due to its high prevalence in MCI individuals)
* Current cancer treatment or other comorbid/unstable medical conditions that might independently affect cognitive function
50 Years
85 Years
ALL
No
Sponsors
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University of Arizona
OTHER
Responsible Party
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Ying-hui Chou
Principle Investigator
Principal Investigators
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Ying-Hui Chou, Sc.D.
Role: PRINCIPAL_INVESTIGATOR
University of Arizona
Central Contacts
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Other Identifiers
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022713-00001
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
25103278
Identifier Type: -
Identifier Source: org_study_id